1,720,996 research outputs found
Fractal aggregation of porcine fumarase induced by free radicals
No full textThe present study demonstrates that H2O2 and OH center dot cause fibril aggregation and catalytic inactivation of porcine fumarase. In the aggregated (oxidized) enzyme, modifications in both secondary and tertiary protein structure occur and the enzyme aggregation obeys to fractal geometry. We then collected information on the fractal dimension and on the size and shape of fumarase aggregates by using Synchrotron Radiation (SR) Small Angle X-ray Scattering (SAXS) analysis. The geometrical self-similarity assessment of aggregates has been revealed by both AFM and SEM measurements at different scale of magnification. Micrographs collected remarkably demonstrate that the oxidized enzyme shows dendn'tic fractal structure over a large range of sizes. (c) 2007 Published by Elsevier B.V
STRUCTURAL PROPERTIES OF HUMAN GLYCODELIN A IN WATER AND WATER-ALCOHOL MIXTURES: A COMPARISON WITH BOVINE BETA-LACTOGLOBULIN A
No full textStructural and kinetic effects of mobile phone microwaves on acetylcholinesterase activity
No full textThe present study provides evidence that "in vitro" simple exposure of an aqueous solution of electric eel acetylcholinesterase (EeAChE; EC 3.1.1.7.) to cellular phone emission alters its enzymatic activity. This paper demonstrates, by combining different experimental techniques, that radio frequency (RF) radiations irreversibly affect the structural and biochemical characteristics of an important CNS enzyme. These results were obtained by using a commercial cellular phone to reproduce the reality of the human exposition. This experimental procedure provided surprising effects collected practically without experimental errors because they were obtained comparing native and irradiated sample of the same enzyme solution. Although these results cannot be used to conclude whether exposure to RF during the use of cellular phone can lead to any hazardous health effect, they may be a significant first step towards further verification of these effects on other "ex vivo" or "in vivo" biological systems. © 2004 Elsevier B.V. All rights reserved
Effects of Mobile Phone Emission on Functional and Conformational Properties of Proteins
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Low Frequency Ultrasound Induces Aggregation of Porcine Fumarase by Free Radical Production
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Synthesis and Characterization of Core-Shell Magnetic Nanoparticles Fe3O4@Cu and Fe3O4@Au for Biomedical applications
No full textSynthesis and Characterization of Core-Shell type Magnetic Nanoparticles Fe3O4@Alginic Acid for radionuclides/medical Storage and Delivery
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