3,592 research outputs found
MP-EST trees (samples as species) for the combined data set and two assemblies.
No full textA) 0.88/0.91 (merged/unmerged) clustering threshold, 50% minimum taxon coverage; B) 0.88/0.82 clustering threshold, 25% minimum taxon coverage. Scale bars are in coalescent units. Terminal branch lengths are not estimated, so the length of collapsed groups (triangles) is not reliable. All shown branch lengths are estimated by MP-EST. Support values from 100 multi-locus bootstrap replicates are only shown for branches with T. "nana" grouped with the top four taxa (as in A) with 46% support.</p
Application of the IS-MP-IA model to the German economy and policy implications
No full textExtending the IS-MP-IA model developed by Romer (2000) and applying the GARCH (Engle, 1982, 2001) methodology, the author finds that equilibrium GDP in Germany is positively affected by stock market performance and real exchange rate appreciation, and negatively influenced by the expected inflation rate, the government deficit/GDP ratio, and the U.S. federal funds rate. The relatively low deficit/GDP ratio of 1.83% in 2003 indicates that its fiscal condition was healthy. However, some other EU members may need to exercise fiscal discipline. Because real appreciation has a positive impact on output, a stronger euro may not be a concern for Germany but may be worried by those EU member nations which depend upon exports to stimulate their economies.
6-Phosphogluconate dehydrogenase: the mechanism of action investigated by a comparison of the enzyme from different species
No full textThe mechanism of action of 6-phosphogluconate dehydrogenase with the alternative substrate 2-deoxy 6-phosphogluconate was investigated using enzymes from sheep liver, human erythrocytes and Trypanosoma brucei. The three enzymes oxidize 2-deoxy 6-phosphogluconate, but only the sheep liver enzyme releases the intermediate 2-deoxy,3-keto 6-phosphogluconate. Kinetic comparison showed that an increase in the rate of NADP reduction at high pH is due to increased release of the intermediate, rather than an increase in the overall reaction rate. 2-Deoxy,3-keto 6-phosphogluconate is decarboxylated by the erythrocyte and trypanosome enzymes but not the liver one in the absence of either NADPH or 6-phosphogluconate, which act as activators. The pH dependence of decarboxylation and the degree of activation suggest that 6-phosphogluconate is the activator which operates under normal assay conditions, while NADPH acts mainly by increasing the binding of the intermediate. The data suggest that the activity of 6PGDH is subjected to a two-way regulation: NADPH, which regulates the pentose phosphate pathway, inhibits the enzyme, while 6-phosphogluconate, levels of which
rise when NADPH inhibition is removed, acts as an activator ensuring that 6-phosphogluconate is rapidly removed
6-Phosphogluconate dehydrogenase from Trypanosoma brucei - Kinetic analysis and inhibition by trypanocidal drugs
No full textThe kinetics of 6-phosphogluconate dehydrogenase from Trypanosoma brucei was examined and compared to those of the same enzyme from lamb's liver. Variation of kinetic parameters as a function of pH suggests a chemical mechanism similar to other 6-phosphogluconate dehydrogenases. The comparison extended to a detailed analysis of the effect on enzyme activity by several inhibitors including the trypanocidal drugs suramin, melarsoprol and analogues of these compounds. The T. brucei enzyme differs significantly from its mammalian counterpart with respect to several inhibitors, particularly the substrate analogue 6-phospho-2-deoxygluconate and the coenzyme analogue adenosine 2',5'-bisphosphate which have respectively 170-fold and 40-fold higher affinity for the parasite enzyme
Winning redefined, a new brand positioning for MP Motorsport
No full textMP Motorsport is a talent educating race team participating in the classes below the Formula 1. The problem with the lower classes and therefore MP Motorsport as well is that these classes don’t get much attention and exposure. As a company run by people with passion the branding and positioning is more something that naturally emerged from this passion rather than a series of conscious decisions. This makes it fragile. A more conscious strategy and vision on how MP Motorsport needs to be branded and positioned against their competition that is more than “look how cool racing is” is needed to become more attractive for sponsoring. This report describes the process from analysis to finding the right positioning and an advise for a new brand identity and an implementation plan to help becoming more attractive for sponsoring goals. The analysis done with employees showed a unique characteristic that will help the team to position themselves against the competition; the family atmosphere. This atmosphere is what also characterises their contradictory personality. This personality is on one hand leading and ambitious and on the other hand modest and involved. Competition and stakeholder analysis have been performed to find the right combination of being unique to the competition, desirable for the stakeholders (the fans and sponsors) and builds upon the core strengths of the company. Then using the brand key model, a positioning is made with the essence: Be your best self. The belief, “in everyone hides a talent” and values like “everyone is equal” and “together we succeed” combined with the essence and the positioning resulted in a brand story that describes the feeling MP Motorsport wants to communicate. To manifestate the brand, an advise has been set up for a tone of voice and tone of image. Wrapped in a concept called “winning redefined” this advise is part of the whole implementation plan that should lead the way for the team to implement the newly created brand in short and long term actions. In 3 phases MP Motorsport is advised to start with a clear brand introduction to the target groups Gen Z and potential sponsors. The next phase revolves around creating a community to attract both Gen Z talents and subsequently sponsors to interact with the team and each other. Finally the last phase is long term focused and aims for sustainable growth. In this phase the community is established and can expect various opportunities to discover and develop a whole range of talents, sponsors and gen z are connected to each other via MP Motorsport and the team is able to finance the lower classes without the pressure of the money drivers bring along.Strategic Product Desig
Derivations (MP) and Evaluations (OT)
No full textThe main claim of this paper is that the minimalist framework and optimality theory adopt more or less the same architecture of grammar: both assume that a generator defines a set S of potentially well-formed expressions that can be generated on the basis of a given input, and that there is an evaluator that selects the expressions from S that are actually grammatical in a given language L. The paper therefore proposes a model of grammar in which the strengths of the two frameworks are combined: more specifically, it is argued that the computational system of human language CHL from MP creates a set S of potentially well-formed expressions, and that these are subsequently evaluated in an optimality theoretic fashion.The definitive version of this paper is published in Linguistics in Potsdam 25 (2006).Broekhuis, H. (2006). Derivations (MP) and Evaluations (OT)*. In H. Broekhuis & R. Vogel (Eds), Linguistics in Potsdam 25. Optimality Theory and Minimalism: A possible Convergence? Potsdam : Universitätsverlag PotsdamISBN: 9783939469544 (published book)This research is supported by the Netherlands Organisation of Scientific Research (NWO), grant 276-70-00
Stroom- en sedimentmeting Roompot-Veerse Dam (mp.8), 15 en 22 januari 1996
No full textStroom- en sedimentmeting Roompot-Veerse Dam (mp.8) 15 en 22 januari 1996.Deltawerken, Oosterscheld
Neural correlates of processing valence and arousal in affective words
No full textPsychological frameworks conceptualize emotion along 2 dimensions, "valence" and "arousal." Arousal invokes a single axis of intensity increasing from neutral to maximally arousing. Valence can be described variously as a bipolar continuum, as independent positive and negative dimensions, or as hedonic value (distance from neutral). In this study, we used functional magnetic resonance imaging to characterize neural activity correlating with arousal and with distinct models of valence during presentation of affective word stimuli. Our results extend observations in the chemosensory domain suggesting a double dissociation in which subregions of orbitofrontal cortex process valence, whereas amygdala preferentially processes arousal. In addition, our data support the physiological validity of descriptions of valence along independent axes or as absolute distance from neutral but fail to support the validity of descriptions of valence along a bipolar continuum
A novel approach to MP-PIC: Continuum particle model for dense particle flows in fluidized beds
No full textA novel approach to Multiphase-Particle-in-Cell (MP-PIC), called Continuum Particle Model (CPM), is developed for dense gas-particle flows. CPM has high computational speed, comparable to that of MP-PIC, but a robustness and accuracy closer to that of a Discrete Element Model (DEM). The gas phase is treated as a continuum phase and particles are tracked discretely, but particle collisions are modelled by considering the divergence of the continuum particle stress tensor. Details on efficient solution to the model are presented. For comparison, a parametric study is performed for quasi-2D fluidized beds. Comparison of CFD-CPM is made with MP-PIC and CFD-DEM. The particle stress models by Harris and Crighton, and by Srivastava and Sundaresan are tested in our CFD-CPM. Results from CFD-CPM based on the Srivastava and Sundaresan particle stress model show good agreement with CFD-DEM results. We validate our model by comparison with experimental benchmark results from Gopalan et. al. (2016).Complex Fluid Processin
US395 : Big Stick Creek - Alkali Lake, Hwy 049 : MP 16.00 - 30.00 & MP 35.16 - 47.00
No full textTitle from PDF cover (viewed on November 4, 2019)."Key No. 21216."This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
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