323,184 research outputs found
<it>"GenotypeColour™"</it>: colour visualisation of SNPs and CNVs
No full textAbstract Background The volume of data available on genetic variations has increased considerably with the recent development of high-density, single-nucleotide polymorphism (SNP) arrays. Several software programs have been developed to assist researchers in the analysis of this huge amount of data, but few can rely upon a whole genome variability visualisation system that could help data interpretation. Results We have developed GenotypeColour™ as a rapid user-friendly tool able to upload, visualise and compare the huge amounts of data produced by Affymetrix Human Mapping GeneChips without losing the overall view of the data. Some features of GenotypeColour™ include visualising the entire genome variability in a single screenshot for one or more samples, the simultaneous display of the genotype and Copy Number state for thousands of SNPs, and the comparison of large amounts of samples by producing "consensus" images displaying regions of complete or partial identity. The software is also useful for genotype analysis of trios and to show regions of potential uniparental disomy (UPD). All information can then be exported in a tabular format for analysis with dedicated software. At present, the software can handle data from 10 K, 100 K, 250 K, 5.0 and 6.0 Affymetrix chips. Conclusion We have created a software that offers a new way of displaying and comparing SNP and CNV genomic data. The software is available free at http://www.med.unibs.it/~barlati/GenotypeColour and is especially useful for the analysis of multiple samples.</p
Metodo di elaborazione e visualizzazione di simboli grafici in un codice colore e relativa rappresentazione su supporti
No full textModification in the frequency of Hb C and Hb S in Burkina Faso: an influence of migratory fluxes and improvement of patient health care.
No full textColture in sospensione, curve di crescita" in: Tecniche di Base e Applicazioni delle Colture Cellulari, CLEUP-Padova, Italia.
No full textColture in sospensione. Curve di crescita
Editorial: Unveiling the neurobiological underpinnings of cognitive dysfunction in patients with schizophrenia
No full textBiological and clinical presentation of patients with hemoglobinopathies attending an urban hospital in Ouagadougou: confirmation of the modification of the balance between Hb S and Hb C in Burkina Faso.
No full text
Differential expression of fibronectin and its degradation products in malignant tumors
No full textThis chapter discusses the differential expression of specific fibronectins (FNs) mRNA isoforms in association with malignant tumors, either in in vivo or in in vitro systems. FNs are high-molecular-weight multifunctional glycoproteins present in the extracellular matrices (ECM) of connective tissues playing a crucial role in cell adhesion, spreading, and migration. In conjunction with the loss of FN, transformed cells lose other ECM components, procollagens, laminin, and heparan sulfate as well as hyaluronic acid. FNs are particularly abundant in body fluids, loose connective tissue, granulation tissue, basement membranes, and in many developing tissues, but are often reduced or absent from the corresponding differentiated tissues. Since FN is maintaining the normal cell phenotype, the expression of FN probably represents a host reaction antagonizing tumor growth and invasion. The activation of proteolysis and the generation of FN degradation products with associated transformation enhancing factor activity may represent a relevant step in tumor growth and progression
Evidence-based psychosocial interventions in schizophrenia: A critical review
No full textPurpose of reviewSchizophrenia Spectrum Disorders (SSD) are severe conditions that frequently produce significant impairment in cognitive performance, social skills and psychosocial functioning. As pharmacological treatment alone often provides only limited improvements on these outcomes, several psychosocial interventions are employed in psychiatric rehabilitation practice to improve of real-world outcomes of people living with SSD: the present review aims to provide a critical overview of these treatments, focusing on those that show consistent evidence of effectiveness.Recent findingsSeveral recent systematic reviews and meta-analyses have investigated in detail the acceptability, the effectiveness on several specific outcomes and moderators of response of different psychosocial interventions, and several individual studies have provided novel insight on their implementation and combination in rehabilitation practice.SummaryCognitive remediation, metacognitive training, social skills training, psychoeducation, family interventions, cognitive behavioral therapy, physical exercise and lifestyle interventions, supported employment and some other interventions can be fully considered as evidence-based treatments in SSD. Psychosocial interventions could be of particular usefulness in the context of early intervention services. Future research should focus on developing newer interventions, on better understanding the barriers and the facilitators of their implementation in clinical practice, and exploring the opportunities provided by novel technologies
- …
