1,720,992 research outputs found
Membrane Ig on MPC11 myeloma cells: correlation between the expression of membrane Ig, a receptor for Ig and the process of secretion
No full textAbsence of beta-globin synthesis and excess of alpha-globin synthesis in homozygous beta-Thalassemia
No full textGlobin chain synthesis has been studied in β‐thalassemia by incubating red blood cells of 10 homozygous thalassemic patients with [3H] amino acids, and by measuring the incorporation of radioactivity into the globin chains, separated by column chromatography. Five of the ten patients were never transfused, five were polytransfused. The following results were obtained: (a) absence of β chain synthesis in both polytransfused and never trasfused patients; (b) excess of α chain synthesis in the ten cases examined (ratio α synthesis/(γ+δ) synthesis = 3.0). In three heterozygous subjects β globin synthesis and an excess of α chain synthesis was observed (ratio α/(β+γ+δ) = 1.6). The possible interpretations of these results are presented in the discussion. Copyright © 1967, Wiley Blackwell. All rights reserve
Lymphocyte membrane immunoglobulins: similarities between human IgD and mouse IgD-like molecules
No full textMLR3 molecule is an activation antigen shared by human B, T lymphocytes and T cell precursors
No full textFunctional characterization of an antigen involved in an early step of T-cell activation
No full textA monoclonal anti-DC1 antibody selectivity inhibits the generation of effector T cells mediating specific cytolytic activity.
No full textThe products of the DC locus have been shown to be structurally different from those of the DR locus. In this paper it is shown that, unlike anti-DR antibodies, a monoclonal antibody directed against DC1 does not affect proliferation of T cells in response to alloantigens or soluble antigens or production of Ig in a pokeweed mitogen-stimulated in vitro culture. However, the anti-DC1 inhibits the generation of effector T cells mediating specific cytolytic activity, whereas no inhibitory effect can be observed on natural killer and antibody-dependen
Functional characterization of a regulatory human T-cell subpopulation increasing during autologous MLR
No full textFunctional characterization of a regulatory human T cell subpopulation increasing during Autologous Mixed Lymphocyte Reaction.
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