22,266 research outputs found

    Perturbations of positive semigroups Factorized via AM– and AL-spaces

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    In this note we extend perturbation results for positive C_0 -semigroups on AM- and AL-spaces generalizing them to arbitrary Banach lattices in case the perturbation can be factorized appropriately. The abstract results are applied to domain perturbations of generators, a heat equation with boundary feedback and perturbations of the first derivative

    Protecting Animals 36: Author Witi Ihimaera

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    In this very special episode of Knowing Animals I am joined by beloved New Zealand author Witi Ihimaera. Witi has written many books featuring nonhuman animals. He offers us a non-colonial lens through which to think about the human/nonhuman relationship

    Arterial stiffness and cognition in the elderly with impaired glucose tolerance and microalbuminuria

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    Rats of the Milan hypertensive strain (MHS) are resistant to both hypertensive and diabetic renal disease. Genetically determined hypertrophy of intrarenal arteries has been suggested as the putative mechanism preventing transmission of systemic hypertension to the glomerular microcirculation or diabetes-induced loss of autoregulation, which lead to glomerular hypertension and consequent podocyte injury and proteinuria. This study aimed to investigate glomerular barrier function and structure in ageing and diabetic MHS rats under basal conditions and after injection of 2.5 g of bovine serum albumin (BSA) causing increased workload and possibly removing haemodynamic protection by inducing renal cortical vasodilatation. Genetically related rats of the Milan normotensive strain (MNS) served as a proteinuric counterpart. No change in renal function or structure was detected in diabetic MHS rats, whereas MNS rats developed diabetic nephropathy superimposed on that occurring spontaneously in this strain. Diabetic, but not non-diabetic, MHS rats showed significantly reduced synaptopodin and nephrin expression, though to a lesser extent than non-diabetic and diabetic MNS rats, together with unchanged podocyte number, density and structure and no proteinuria. Agrin expression was significantly altered in diabetic versus non-diabetic MHS animals, whereas collagen I was expressed only in diabetic MHS rats and collagen IV content did not change significantly between the two groups. Upon BSA injection, proteinuria increased markedly and abundant BSA was detected only in kidneys from diabetic MHS rats. BSA injection was associated with changes in intrarenal arteries suggesting vasodilatation, without any influx of inflammatory cells. These data indicate that while MNS rats show marked changes in the glomerular filtration barrier with either age or diabetes, glomerulosclerosis-resistant MHS rats develop only minor diabetes-induced podocyte (and extracellular matrix) alterations, which are not associated with proteinuria unless they are unmasked by an increased workload or removal of the haemodynamic protection

    Ribautia proxima Pereira, Minelli & Barbieri 1995

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    Ribautia proxima Pereira, Minelli & Barbieri, 1995 Ribautia (Ribautia) proxima Pereira, Minelli & Barbieri 1995, Amazoniana 13 (3–4): 325, 331 – 333, figs. 88–122 The species was hitherto known only from the type locality: Brazil: Amazonas: Reserva Florestal A. Ducke. We have recently identified material from the following additional localities: Brazil: Amazonas: secondary upland forest (02º 34 ' S 60 º 06' W), capoeira, 7.11. 1990, M. O. de A. Ribeiro leg.: 1 juvenile (Ψ?), 79 p. l., b.l. 14 mm (INPA); ibid., 3.1.1991: 1 Ψ with the two spermathecae full of spermatozoa and with mature ova, 81 p. l., b.l. 32 mm; 2 juveniles (ɗɗ?), 75 and 77 p. l., b.l. 14 mm; 1 juvenile (Ψ?), 81 p. l., b.l. 19 mm; 2 juveniles (incomplete) (AM). Brazil: Amazonas: Rio Tarumã Mirím, capoeira, 25.4. 1983, J. Adis leg.: 1 Ψ with the two spermathecae full of mature spermatozoa, 79 p. l., b.l. 32 mm (MLP). Guyane Française: Piste de St. Elie: 16 Km from Sinnamary, J.­M. Betsch leg.: 1 Ψ with the two spermathecae full of spermatozoa, 73 p. l., b.l. 26 mm, 5.5. 1980 (MNHN); 1 Ψ with the two spermathecae full of spermatozoa, 75 p. l., b.l. 25 mm, 9.5. 1980 (MNHN); 1 ɗ with tubula seminifera full of mature spermatozoa, 73 p. l., b.l. 21 mm; 1 juv. (sex?) with only 3 + 3 coxal organs, 75 p. l., b.l. 10 mm, 5.6. 1981 (MNHN). The recently studied material includes specimens with number of leg pairs other than those recorded thus far, i.e. ɗɗ with 81 pairs of legs.Published as part of Pereira, Luis A., Uliana, Marco & Minelli, Alessandro, 2006, New species and new records of the genus Ribautia Brölemann, 1909 (Chilopoda: Geophilomorpha: Geophilidae) from South America, pp. 45-68 in Zootaxa 1106 on pages 66-67, DOI: 10.5281/zenodo.17144

    I Think I Am Philip K. Dick

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    For years, noted writer Laurence A. Rickels often found himself compared to novelist Philip K. Dickthough in fact Rickels had never read any of the science fiction writers work. When he finally read his first Philip K. Dick novel, while researching for his recent book The Devil Notebooks , it prompted a prolonged immersion in Dicks writing as well as a recognition of Rickelss own long-documented intellectual pursuits. The result of this engagement is I Think I Am: Philip K. Dick , a profound thought experiment that charts the wide relevance of the pulp sci-fi author and paranoid visionary. I Think I Am: Philip K. Dick explores the science fiction authors meditations on psychic reality and psychosis, Christian mysticism, Eastern religion, and modern spiritualism. Covering all of Dicks science fiction, Rickels corrects the lack of scholarly interest in the legendary Californian author and, ultimately, makes a compelling case for the philosophical and psychoanalytic significance of Philip K. Dicks popular and influential science fiction.Intro -- Contents -- Introjection -- Part I -- Endopsychic Allegories -- Schreber Guardian -- Belief System Surveillance -- Part II -- Deeper Problems -- Veil of Tears -- Go West -- Dick Manfred -- Timing -- Glimmung -- Part III -- Spiritualism Analogy -- Imitating the Dead -- Indexical Layer -- Ilse -- Hammers and Things -- Crucifictions -- Over There -- Martyrology -- Can't Live, Can't Live -- Lola -- Umwelt, Mitwelt, and Eigenwelt -- Outer Race -- The German Introject -- Part IV -- Materialism, Idealism, and Cybernetics -- Startling Stories -- A Couple of Years -- Android Empathy -- Homunculus and Robot -- ALL OF YOU ARE DEAD. I AM ALIVE. -- Go with the Flow -- Part V -- Room for Thought -- Caduceus -- Jump -- Still -- A Wake -- Spätwerk -- Let the Dead Be -- Play Bally -- Das Hund -- Notes -- BibliographyFor years, noted writer Laurence A. Rickels often found himself compared to novelist Philip K. Dickthough in fact Rickels had never read any of the science fiction writers work. When he finally read his first Philip K. Dick novel, while researching for his recent book The Devil Notebooks , it prompted a prolonged immersion in Dicks writing as well as a recognition of Rickelss own long-documented intellectual pursuits. The result of this engagement is I Think I Am: Philip K. Dick , a profound thought experiment that charts the wide relevance of the pulp sci-fi author and paranoid visionary. I Think I Am: Philip K. Dick explores the science fiction authors meditations on psychic reality and psychosis, Christian mysticism, Eastern religion, and modern spiritualism. Covering all of Dicks science fiction, Rickels corrects the lack of scholarly interest in the legendary Californian author and, ultimately, makes a compelling case for the philosophical and psychoanalytic significance of Philip K. Dicks popular and influential science fiction.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries

    On Structured Perturbations of Positive Semigroups

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    In this thesis we study perturbation results for the generator A of a positive C_0--semigroup on a Banach lattice X. We generalize results that hold for an AM- or AL-space X and extend them to an arbitrary Banach lattice X in case the perturbation can be factorized as P=BC via an AM- or AL-space U. This allows to deal with applications on (infinite dimensional) reflexive Banach spaces, which are a priori excluded if X is an AM- or an AL-space. First, B and C are assumed to be positive operators satisfying the spectral condition r(CR(\lambda,A_{-1})B)\omega_0(A). We then prove that the generation results obtained in this case still hold when B and C are not necessarily positive, but only dominated by positive operators. These abstract results are applied to domain perturbations of generators, a heat equation with boundary feedback and perturbations of the first derivative. Combining the previous results we then deal with "doubly unbounded" perturbations P:Z\to X_{-1}, provided they can be factorized as P=BC via U=\mathbb{R}^N. In this context, we prove a Staffans--Weiss type perturbation result. We show that the classically assumed admissibility and invertibility conditions for the associated input--output map \mathcal{F}_\infty follow from the (much simpler to verify) spectral condition mentioned above. The abstract results are applied to domain perturbations and finite rank perturbations of the first derivative

    Seven novel additional small mutations and a new alternative splicing in the human dystrophin gene detected by heteroduplex analysis and restricted RT-PER heteroduplex analysis of illegitimate transcripts

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    Around 35% of Duchenne and Becker muscular dystrophy (DMD/BMD) patients cannot be identified by techniques which identify major DMD rearrangements in the dystrophin gene. In order to characterize the gene defect in these patients, we screened 40 exons of the dystrophin gene by heteroduplex analysis on genomic DNA in 50 affected Italian males. Using conventional heteroduplex analysis and a modified heteroduplex analysis on restricted RT-PCR products of illegitimate transcripts, restricted RT-PCR heteroduplex analysis, we were able to identify 7 novel small mutations and a new alternative splicing involving exon 25 of the dystrophin gene in peripheral blood lymphocytes and skeletal muscle transcript
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