86,584 research outputs found
Agility in assembly systems: A comparison model
No full textThis paper aims at analyzing different possible assembly systems, including innovative potential configurations such as the fully flexible assembly systems (FAS), by defining a novel analytical model that focuses on the concept of agility and its impact on the whole system performance, also evaluating the economic convenience in terms of the unit direct production cost. Design/methodology/approach - The authors propose a comparison model derived by Newton's second law, introducing a quantitative definition of agility (acceleration), resistance of an assembly system to any change of its operative state (inertia) and unit direct production cost (force). Different types of assembly systems (manual, flexible and fully FAS) are analyzed and compared using the proposed model, investigating agility, system inertia and their impact on the unit direct production cost. Findings - The proposed agility definition and the proposed comparison model have been applied considering different sets of parameters as independent variables, such as the number of components to assemble (product model complexity) and the target throughput of the system. The main findings are a series of convenience areas which either, for a given target unit direct production cost (force), defines the most agile system to adopt or, for a given target agility (acceleration), defines the most economical system to adopt, as function of the independent variables. Originality/value - The novelty of this work is, first, the analytical definition of agility applied to assembly systems and contextualized by means of the definition of the new comparison model. The comparison between different assembly systems on the basis of agility, and by using different sets of independent variables, is a further element of interest. Finally, the resulting convenience areas represent a desirable tool that could be used to optimally choose the most suitable assembly system according to one or more system parameters
Role of fine needle aspiration cytology in the preoperative evaluation of smooth muscle tumors
No full textI.F. 0.93
Trajectory planning of a suspended cable driven parallel robot with reconfigurable end effector
No full textIn this paper, a new suspended cable driven parallel robot (CDPR) with reconfigurable end effector is presented. This robot has been conceived for pick and place operations in industrial environments. For such applications, the possibility to change the configuration of the cables at the end-effector level is a promising way to avoid collisions with obstacles in the approaching phases, while reducing at the same time the duration of motion in the remaining part of the trajectory. An optimized trajectory planning algorithm is proposed, which implements a pick and place operation in the operational space with dynamic on-line reconfiguration of the end effector. The results on a simplified scenario demonstrate the ability of the system to obtain reduced movement times together with obstacle avoidance
Preliminary monocentric results of biological characteristics of pregnancy associated breast cancer
No full textPurpose: We performed a mono-institutional study for evaluating the biological data, such as p53, Ki67 and BRCA mutations, as well as clinical characteristics of pregnancy associated breast cancer (PABC), its therapeutic management and the prognosis in a small cohort of patients. Materials and methods: We retrospectively examined 26 patients with PABC. Clinical and histopathological characteristics along with Ki67, p53 and BRCA mutations were analysed. Information about chemotherapy, surgery and radiotherapy was recovered. Data about long-term prognosis was registered and computed by Kaplan-Meier analysis. Results: Of 26 patients, 17 (65%) were considered as having a locally advanced breast cancer. The majority of them (65.4%) had a ductal invasive carcinoma. Oestrogen and progesterone receptors were positive in 13 (50%) patients, resulting both negative in four (15.4%) subjects. HER-2 was positive in 5 subjects (19.2%). Ten patients underwent conservative surgery treatment, and 14 were sent to radical mastectomy (38 vs. 54%) associated with axillary lymph node dissection in 18 cases. Many patients (65%) were further treated with adjuvant chemotherapy and/or hormone therapy. Eight out of 11 patients undergoing the evaluation of BRCA mutation were positive while only 2 out of 3 patients had a mutation of p53. After a median follow-up of 110 months (range: 8.2-1227mo.), 18 women were still alive, six patients (25%) died and two were lost. Three patients showed a loco-regional recurrence, after a median period of 26 months (range: 2-42mo.). Distant metastases verified in six patients after a median period of 12.5 months (range: 2-108mo.). The prognosis was less favourable in BRCA mutated patients than no-BRCA mutated group, although not statistically significant. Conclusions: In women with PABC, the initial stage of disease is more advanced requiring more aggressive treatment
PRELIMINARY MONOCENTRIC RESULTS OF BIOLOGICAL CHARACTERISTICS OF PREGNANCY ASSOCIATED BREAST CANCER
No full textHybrid Flexible Assembly Systems (H-FAS): Bridging the gap between traditional and fully flexible assembly systems
No full textAutomation can be a valid way to reduce production costs. Considering medium/low volumes and a wide set of different models, a mixed model assembly work cell is a proper automated production system. The authors have recently introduced a new class of flexible assembly systems (FAS), the F-FAS, in which highly flexible feeding systems are used to improve the flexibility and reduce the set-up times at batch change. Such systems, guaranteeing a higher level of flexibility than traditional automated FAS, show some limitations in terms of productivity, due to the stochastic process of feeding and reorientation of parts and to the time spent for image acquisition and processing. The aim of this paper is to introduce an innovative automated assembly work cell, called the hybrid flexible assembly system (H-FAS), that merges the traditional FAS bowl feeder utilisation with the innovative F-FAS feeding concepts. The paper analyses the main factors influencing the H-FAS design, productivity and cost. Moreover, through a comparative analysis between the different single cell assembly systems, it defines the working conditions in which they can be preferable
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Role of transarterial Chemoembolization Befero Liver Resection For Hepatocarcinoma
No full textThe aim of this study was to clarify whether chemoembolization (TACE) before liver resection (LR) can reduce postoperative hepatocellular carcinoma (HCC) recurrence and improve disease-free and overall survival. Eighty-nine patients with tumor-stage (TNM) I-II HCC were evaluated for LR. Patients were prospectively allocated to LR alone or TACE plus LR based on their place of residence. Twenty nonlocal patients (24%) were selected for LR, while 69 (77.5%) local patients were selected for TACE plus LR. Following TACE, the tumor stage could be confirmed in only 20 patients (29%) who then underwent LR. Operative mortality was 0%, but in the TACE-LR group, 3 patients died of liver failure between 2 and 5 months after surgery. Early recurrence (<24 months) was 59% for LR versus 20% for TACE plus LR (P <.05). Late recurrence was 18% for LR versus 10% for TACE plus LR (P = not significant [NS]). The overall recurrence rate was 76% for LR versus 30% for TACE plus LR (P <.02). Death due to HCC recurrence was 70% for LR versus 15% for TACE plus LR (P <.05). The overall 1- and 5-year survival rates did not differ significantly (71% to 38% for LR v 85% to 43% for TACE + LR; P = NS), whereas the difference in 1- and 5-year disease-free survival was highly significant (64% to 21% for LR v 82% to 57% for TACE + LR; P <.02). TACE was able to improve the HCC staging process and significantly reduce the incidence of early and overall HCC recurrence and related death after LR; it improved the disease-free interval, but not the overall survival, due to an increase in liver failure in the first 5 months
Localization of hepatitis C virus (HCV) antigen by immunohistochemistry on fixed-embedded liver tissue
No full text[Newspaper Clipping: Author Claims Evidence of Second JFK Assassin #1]
No full textNewspaper article titled "Author Claims Evidence of Second JFK Assassin." The article states that author Richard J. Whalen concluded "that there is circumstantial evidence to support the theory of a second assassin in the shooting of President John F. Kennedy.
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