102,246 research outputs found
Oxidative stress and antioxidant status in patients with erectile dysfunction
No full textIntroduction.
Erectile dysfunction (ED) is increasingly recognized as a public health problem. The interaction between nitric oxide and reactive oxygen species is one of the important mechanisms implicated in the pathophysiological process of ED. Plasma contains various antioxidant components to prevent free-radical injury.
Aim.
The aim of this study was to determine and compare the oxidative and antioxidant status of peripheral venous blood in patients with ED of arteriogenic and non-arteriogenic origin.
Methods.
Oxidative stress and antioxidant status were assessed in 40 patients with ED and 20 healthy controls.
Main Outcome Measures.
Plasma reactive oxygen metabolite (ROM) concentrations were measured as an indicator of oxidative stress, and plasma total antioxidant status (TAS) to indicate antioxidant defense.
Results.
Plasma ROM concentrations were higher (349.75 +/- 53.35 standard deviation [SD] U.Carr vs. 285.43 +/- 25.58 U.Carr, P < 0.001) and plasma TAS lower (0.54 +/- 0.16 SD mmol/L vs. 0.94 +/- 0.28 SD mmol/L, P < 0.0001) in patients with arteriogenic ED in comparison to those in patients with non-arteriogenic ED. Plasma ROM and TAS in controls were not significantly different from those in non-arteriogenic ED.
Conclusions.
This observation may be useful to better understand and distinguish arteriogenic from non-arteriogenic ED using laboratory tests. In addition, our findings provide important support for an antioxidant therapy to try to correct oxidative stress in arteriogenic ED patients. Barassi A, Colpi GM, Piediferro G, Dogliotti G, Melzi D'Eril GV, and Corsi MM. Oxidative stress and antioxidant status in patients with erectile dysfunction
Adipokines, hormonal parameters, and cardiovascular risk factors : similarities and differences between patients with erectile dysfunction of arteriogenic and nonarteriogenic origin
No full textIntroduction. Erectile dysfunction (ED) is often associated with metabolic disorders. Leptin and adiponectin are adipose tissue-derived hormones involved in the regulation of metabolic homeostasis and considered important players in the relationship among obesity and cardiovascular diseases. Aim. Leptin, adiponectin, leptin to adiponectin ratio (L/A), and their correlation with hormonal and metabolic parameters were examined in male with arteriogenic- (A-ED) and nonarteriogenic-ED (NA-ED). Main Outcome Measures. Biochemical, metabolic, and hormonal parameters of men with A-ED were compared with those of male with NA-ED. Methods. Diagnosis of ED was based on the International Index of Erectile Function Score. Its etiology was classified with penile echo-color Doppler at baseline and after intracavernous injection of prostaglandin E1. Leptin and adiponectin were measured by enzyme-linked immunosorbent assay. Results. In A-ED subjects, increased levels of insulin, glycated hemoglobin, homeostasis model assessment of insulin resistance (HOMA-IR) index, body mass index (BMI), leptin, and L/A and decreased levels of total, free, and bioavailable testosterone were observed compared with NA-ED subjects. A trend toward lower estradiol level was also present in A-ED patients, even if not statistically significant. Reduced levels of adiponectin have been observed in both groups compared with patients without ED. Leptin and L/A correlated similarly with several parameters (negatively with testosterone/estradiol ratio and positively with BMI, insulin, HOMA-IR, and 17-beta estradiol). L/A resulted further correlated negatively with high-density lipoprotein and positively with triglycerides. Conclusions. Not all ED cases are similar. In fact, A-ED patients display a more complicated metabolic status characterized by overweight and obesity and associated to sexual hormone alteration. Whether changes in body composition and modulation of adipokine levels can improve local endothelial function need further investigation. Dozio E, Barassi A, Dogliotti G, Malavazos AE, Colpi GM, D'Eril GVM, and Corsi MM. Adipokines, hormonal parameters, and cardiovascular risk factors: Similarities and differences between patients with erectile dysfunction of arteriogenic and nonarteriogenic origi
Serum amyloid A: Biology and clinical application [La siero amiloide A: Biologia ed applicazioni cliniche]
No full text
Effects of the whole-body cryotherapy on NTproBNP, hsCRP and troponin I in athletes
No full textWhole-body cryotherapy refers to brief exposure to very cold air for treating symptoms of various illnesses. In sports medicine, whole-body cryotherapy is administered to improve recovery from muscular trauma. As specific studies are lacking, we measured cardiac markers in 10 top-level rugby players of the Italian National team before and after a 1-week course of daily sessions of whole-body cryotherapy. All subjects continued with the same training workload as that of the previous weeks. N-terminal pro B-type natriuretic peptide (NTproBNP) levels increased but remained within the normal range, whilst troponin I (TnI) and high sensitivity C-reactive protein (hsCRP) were unchanged. Whole-body cryotherapy did not impair cardiac function in this sample of elite athletes
EFFICACIA DELLA RIABILITAZIONE RESPIRATORIA IN ACQUA NEL TRATTAMENTO DELL'ASMA BRONCHIALE IN SOGGETTI PEDIATRICI
No full textBeneficial effects of the whole-body cryotherapy on sport haemolysis
No full textBackground. Sport’s anemia is a common risk for athletes. The principal source of an accelerated
turnover of the erythrocytes in sportsmen is the intravascular hemolysis. This phenomenon is induced
by mechanical breakage for impact of feet and muscular contractions, but also by osmotic changes
causing membrane fragility, typically evident after exercise, when free radicals are increased. Wholebody
cryotherapy (WBC) covers a wide range of therapeutic applications and consists of briefly
exposing the body to extremely cold air. In sports medicine, WBC is used to improve recovery from
muscle injury; however, empirical studies on its application to this area are lacking. Design and
Methods. We recruited ten rugby players of the Italian National Team. In these athletes we measured
hematological parameters, before including mean sphered cell volume (MSCV) by means of Coulter
LH750, besides of haptoglobin, and after WBC. The subjects underwent five sessions on alternate
days once daily for one week. During the study period, the training workload was the same as that of
the previous weeks. Results. We observed in the athletes increase of haptoglobin and an increase of
MSCV after the treament period. Conclusions. WBC reduces sports haemolysis, as judged from
MSCV and haptoglobin data, supported from other haematological values, as well as the absence of
mean corpuscolar volume and reticulocytes increase. Th
N-terminal proB-type natriuretic peptide (NT-proBNP) concentrations in elite rugby players at rest and after active and passive recovery following strenuous training sessions
No full textBACKGROUND: The serum biomarker N-terminal proB-type natriuretic peptide (NT-proBNP), a cleaved fragment of the brain natriuretic peptide (BNP) precursor (amino acids 1-76), is accepted as a standard marker for evaluating and monitoring cardiac injury characterized by myocardial wall stress. Strenuous exercise may generate transitory ischemia, myocardial stress and diastolic left ventricular dysfunction, possibly inducing increased concentrations of NT-proBNP. A purported caveat to prolonged strenuous exercise is based on evidence for biochemical and structural signs of heart dysfunction in recreational athletes after continuous exertion. METHODS: We compared NT-proBNP levels in three groups of physically fit subjects: top-level rugby players, professional soccer players and healthy controls. NT-proBNP concentrations were measured at rest and after an intensive training session followed by two different recovery strategies (passive or active). RESULTS: A comparison of the three samples showed that NT-proBNP concentrations in the rugby players were lower than those in controls at rest and were similar to those in professional soccer players. Elevated post-training NT-proBNP levels were unaffected by the type of recovery. The relatively high NT-proBNP levels after active recovery when psychophysical stress is higher, because of cycling and cold water immersion, suggest that not only endurance exercise, but also strenuous, stressful short exercise can induce an increase in NT-proBNP concentrations. CONCLUSIONS: In this sample of professional athletes, NT-proBNP was low at rest, and the increase after physical exercise was physiological
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