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Pregnancy, microchimerism and autoimmunity: An update
No full textThe presence of a small population of cells or DNA in one individual that derives from another genetically distinct person is referred to as microchimerism; this process may occur in course of pregnancy from mother to fetus, and vice versa. The clinical similarities between some features of autoimmune diseases and the chronic graft versus host disease, the increased incidence of autoimmune diseases observed in women after childbearing age, and the long-term persistence of microchimerism have raised the hypothesis that microchimerism could be involved in the pathogenesis of autoimmune diseases. To assess the possible relationship between pregnancy and the incidence of systemic sclerosis we performed a hospital-based case-control study. Our results, indicating a reduced risk for systemic sclerosis in women who had been pregnant in comparison with women who had not, seem to indicate that pregnancy is not a risk factor for systemic sclerosis
I reumatismi infiammatori: Malattia reumatica, Artrite Reumatoide, Spondiloartriti sieronegative, Artriti infettive.
No full text
Azathioprine hypersensitivity in a patient affected by systemic lupus erythematosus
No full textAzathioprine hypersensitivity in a patient affected by systemic lupus erythematosu
Liver impairment after concomitant administration of bosentan and clarithromycin in systemic sclerosis
No full textBosentan, an orally administered dual endothelin (A) and endothelin (B) receptor antagonist is indicated in the rheumatologic field for the treatment of pulmonary arterial hypertension related to connective tissue diseases [1] and for the prevention of the development of ischemic digital ulcers in systemic sclerosis [2]. As known, the drug may cause liver dysfunction; a recent report of a postmarketing surveillance quantified the increase of aminotransferase levels in 7.6% of the bosentan-treated patients [3].
Here we describe two cases of liver dysfunction after concomitant administration of bosentan and clarithromycin in systemic sclerosis
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