1,721,057 research outputs found
Laboratory-based versus non-laboratory-based CVD risk analysis.
No full textLetter
Comment on
Laboratory-based versus non-laboratory-based method for assessment of cardiovascular disease risk: the NHANES I Follow-up Study cohort. [Lancet. 2008
Letter by Bocelli et al regarding article, "A novel method of expressing left ventricular mass relative to body size in children"
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Determinants of discrepancy between left ventricular chamber systolic performance and effective myocardial contractility in subjects with hypertension.
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Rosuvastatin-acenocoumarol interaction.
No full textBACKGROUND: Previous evidence suggests that hydroxymethylglutaryl coenzyme A-reductase inhibitors (statins) might potentiate the effect of oral anticoagulants, but a MEDLINE search (key terms: stains, rosuvastatin, anticoagulants, acenocoumarol, and interaction; years: 1980-2005) revealed no reports of an interaction between rosuvastatin and acenocoumarol.
OBJECTIVE: The aim of this article was to describe a case of possible interaction between rosuvastatin and acenocoumarol.
METHODS: We report the case of a 36-year-old male patient receiving long-term oral treatment with acenocoumarol, a synthetic coumarin anticoagulant, who experienced an increase in international normalized ratio (INR) and a hematoma in the left leg approximately 45 days after the initiation of treatment with rosuvastatin.
RESULTS: After discontinuation of both drugs, an unexpectedly rapid decrease in INR was observed.
CONCLUSIONS: Based on the results of this case, a possible pharmacologic interaction between rosuvastatin and acenocoumarol should be considered. Rosuvastatin might enhance the anticoagulant effect of acenocoumarol, and a rebound effect in cases of simultaneous discontinuation of both drugs might occur. Rosuvastatin should be administered with extreme caution in patients receiving long-term acenocoumarol therapy
Letter by Ballo et al regarding article, "Serial biomarker measurements in ambulatory patients with chronic heart failure: the importance of change over time"
No full textComment on
Serial biomarker measurements in ambulatory patients with chronic heart failure: the importance of change over time. [Circulation. 2007
Late mitral annuloplasty failure: the loss of the ring.
No full textAbstract
An 81-year-old man complained with increasing dyspnoea and asthenia few months after a successful double mitral and tricuspid valvuloplasty intervention. The echocardiogram revealed a partial detachment of the mitral annuloplasty ring due to dehiscence determining a severe regurgitation. Curiously, at Color-Doppler analysis of mitral inflow, the prolapse of the detached ring produced a fascinating circular line inside the regurgitation signal, mimicking the shape of a gemstone ring. We described a case of a relatively uncommon cause of late mitral valvuloplasty failure characterized by a really unusual echocardiographic finding
Adaptive and maladaptive cardiac hypertrophy: what is the effective role of heat shock transcription factor 1?
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Upregulation of heat shock transcription factor 1 plays a critical role in adaptive cardiac hypertrophy
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