1,721,144 research outputs found
Epidemiology of jellyfish stings reported to summer health centres in the Salento peninsula (Italy)
No full textBackground: The presence of jellyfish along coasts constitutes a potentially serious public health problem because of the toxic effects of contact with them. Objective To determine the epidemiology of jellyfish stings in the Province of Lecce, Italy, in 2007. Methods: The study involved the gathering and processing of data on patients seeking medical treatment at summer first aid centres and hospitals along the coast of Salento following contact with jellyfish. Results: In 2007, 446 bathers sought medical assistance following contact with jellyfish. The spatial distribution indicates a greater frequency of stings sustained along the Adriatic coast, while the time analysis shows patterns related to wind direction. Most of the injuries were seen in persons aged between 1 and 10 years and in females. In 24% of cases, injuries were sustained to several parts of the body, while single injuries were mainly to the lower limbs (33%). In 4.9% of cases, there were complications, including one case of anaphylactic shock. Conclusion In the light of the significant level of medical assistance provided, there is a need to identify suitable strategies that will guarantee the best response in terms of both prevention and treatment. © 2009 John Wiley & Sons A/S
Ifp35 is a relevant factor in innate immunity, multiple sclerosis, and other chronic inflammatory diseases: A review
Full text linkDiscovered in 1993 by Bange et al., the 35-kDa interferon-induced protein (IFP35) is a highly conserved cytosolic interferon-induced leucine zipper protein with a 17q12-21 coding gene and unknown function. Belonging to interferon stimulated genes (ISG), the IFP35 reflects the type I interferon (IFN) activity induced through the JAK-STAT phosphorylation, and it can homodimerize with N-myc-interactor (NMI) and basic leucine zipper transcription factor (BATF), resulting in nuclear translocation and a functional expression. Casein kinase 2-interacting protein-1 (CKIP-1), retinoic acid-inducible gene I (RIG-I), and laboratory of genetics and physiology 2 Epinephelus coioides (EcLGP2) are thought to regulate IFP35, via the innate immunity pathway. Several in vitro and in vivo studies on fish and mammals have confirmed the IFP35 as an ISG factor with antiviral and antiproliferative functions. However, in a mice model of sepsis, IFP35 was found working as a damage associated molecular pattern (DAMP) molecule, which enhances inflammation by acting in the innate immune-mediated way. In human pathology, the IFP35 expression level predicts disease outcome and response to therapy in Multiple Sclerosis (MS), reflecting IFN activity. Specifically, IFP35 was upregulated in Lupus Nephritis (LN), Rheumatoid Arthritis (RA), and untreated MS. However, it normalized in the MS patients undergoing therapy. The considered data indicate IFP35 as a pleiotropic factor, suggesting it as biologically relevant in the innate immunity, general pathology, and human demyelinating diseases of the central nervous system
I miceti come potenziale indice di contaminazione fecale in vegetali commercializzati e non.
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Comparative survival of faecal and human contaminants and use of Staphylococcus aureus as an effective indicator of human pollution
No full textComparative survival tests of faecal coliforms (FC), faecal streptococci (FS), Salmonella spp. and Staphylococcus aureus grown in sea (35‰ of salinity) and brackish water (27‰ of salinity) were performed in the dark at room temperature (22±2°C). In seawater T90 was: S. aureus>FS>Salmonella spp.>FC. Survival in brackish water generally appeared to be higher than in seawater; in particular this increased from 48 to 72 h, from 88 to 104 h and from 56 to 80 h, respectively for FC, FS and Salmonella spp. A lower salinity had no effect on the survival rates of S. aureus whose T90 remained stable (96 h). FC proved to be the most sensitive bacteria to salinity and S. aureus the most adaptable one. There should be caution in interpreting these data; however it seems that S. aureus could be an effective indicator of human pollution and that the microbiological parameters used for the control of seawater could be reconsidered. Copyright (C) 2000 Elsevier Science Ltd
Comparative survival of fecal and human contaminants and use of Staphylococcus aureus as an effective indicator of human pollution
No full textEvoluzione della flora microbica e della sostanza organica in un'acqua minerale imbottigliata
No full textLa situazione igienica del litorale Salentino. Nota II. Aspetti microbiologici in campioni di mitili prelevati dai banchi di vendita
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