1,721,025 research outputs found
Predicting long walking capacity from the timed 25-foot walk test in persons with multiple sclerosis - a potential simple aid to assist ambulation scoring?
No full textBackground: : In people with multiple sclerosis (pwMS), no formula exists to predict long walking capacity.Objective: : To examine the accuracy of the timed 25-foot walk (T25FW) to predict long walking in pwMS with various degrees of walking dysfunction. Methods: : A linear regression was made between the T25FW and the 6-minute walk test (6MWT) using data from 498 pwMS.Results: : Prediction showed an excellent agreement between actual and predicted 6MWT distances, with an acceptable error of 10%, which increased as walking dysfunction increased.Conclusions: : The T25WT provided acceptable prediction of the 6MWT in pwMS, although less accurate at higher degrees of dysfunction.The author(s) received no financial support for the research, authorship, and/or publication of this article.
The RIMS network (www.eurims.org) is acknowledged for facilitating inter European consultation and testing. All data-collecting centers REVAL Rehabilitation Research Center, Hasselt (D. Gijbels, I. Baert, B.O. Eijnde and I. Wens); Rehabilitation and
MS Center Overpelt, Overpelt (K. Knuts); National MS Center, Melsbroek (B. Gebara); Centre Neurologique et de R´eadaptation Fonctionelle, Fraiture-en-Condroz (B. B. Maertens de Noordhout); Charles University Prague and General Faculty Hospital, Prague (K. Rasova); MS Centers of Haslev and Ry (E. Jensen and A. Skjerbaek); West-Tallinn Central Hospital, Tallinn (Heigo Maamagi); ¨ Masku Neurological Rehabilitation Center, Masku (A. Romberg); School of Health Professions, Plymout
University, Plymouth, United Kingdom (J. Freeman); Norwegian Multiple Sclerosis Competence Center, Department of Neurology, and Department of Physiotherapy, Haukeland University Hospital, Bergen, Norway (T. Smedal); Poole hospital NHS foundation trust, Dorset, United Kingdom (H. Conyers); Eugenia Epalza D. Rehabilitation Center, Bilbao, Spain (IE.. Minguez); Helsinki MS-Neuvola, Finland (J. Gumse); MS Center Hakadal AS, Norway (A. Heric-Mansrud); Center for MS,
University Medical Center Ljubljana, Slovenia (A. Martic); Kongsgaarden Physiotherapy AS/Nordland Hospital Trust, Bodø, Norway (B. Norman); Hospital de Dia de Barcelona, CEMCat, Spain (C. Santoyo); Sheba Medical Center, Tel-Hashomer, Israel and The Mellen Center for MS Treatment and Research, Cleveland, USA (F. B´ethoux)
Test-retest reliability of motor and cognitive dual task cost in Multiple Sclerosis during various tasks
No full textTest-retest reliability of motor and cognitive dual task cost in Multiple Sclerosis during various tasks
No full textTest-retest reliability of cognitive-motor interference assessments in walking with various task complexities in persons with Multiple Sclerosis
No full textBackground. Simultaneous execution of motor and cognitive tasks can result in worsened performance on one or both tasks, indicating cognitive-motor interference (CMI). A growing amount of research on CMI in persons with multiple sclerosis (pwMS) is observed. However, psychometric properties of dual-task outcomes have been scarcely reported. Objective. To investigate the between-day test-retest reliability of the motor and cognitive dual-task costs (DTCs) during multiple CMI test conditions with various task complexities in pwMS and matched healthy controls (HCs). Methods. A total of 34 pwMS (Expanded Disability Status Scale score 3.0 +/- 0.8) and 31 HCs were tested and retested on 3 single cognitive, 4 single motor, and 12 cognitive-motor dual tasks. Cognitive tasks included serial subtraction by 7, titrated digit span backward, and auditory vigilance. Motor tasks were walking at self-selected speed, over obstacles, crisscross, and while carrying a water-filled cup. Outcome measures were cognitive and motor DTC, calculated as percentage change of dual-task performance compared with single-task performance. Intraclass correlations (ICCs) and Spearman correlation coefficients were calculated as appropriate. Results. For DTCmotor of gait speed, ICCs ranged from 0.45 to 0.81 and Spearman correlations from 0.74 to 0.82. For DTCcognitive, ICCs ranged from -0.18 to 0.49 and Spearman correlations from -0.28 to 0.26. Reliability depended on the type of motor and cognitive task. Conclusion. Reliability of the DTCmotor was, overall, good, whereas that of the DTCcognitive was poor. The "walking" and "cup" dual-task conditions were the most reliable regardless of the integrated cognitive task
Comparing 16 different dual-tasking paradigms in individuals with multiple sclerosis and healthy controls : working memory tasks indicate cognitive-motor interference
No full textBackground: Cognitive-motor interference (CMI) is measured by dual-tasking (DT), which involves motor and cognitive tasks. There is no consensus as to whether CMI is present in multiple sclerosis (MS).
Objectives: We investigated the effects of 16 DT conditions by measuring motor complexity, cognitive domain, and task difficulty.
Method: In total, 40 persons with MS (pwMSs) with Expanded Disease Status Scale (EDSS) 3.2 +/- 1.7 and 31 age- and sex-matched healthy controls (HCs) completed 2 single walking, 8 single cognitive, and 2 complex walking tasks and 16 cognitive-motor DT. The main outcomes were mean values of gait velocity and the percentage change from single to DT (motor DT costs, mDTCs) and mean values of cognitive task accuracy and the percentage changes (cognitive DTC, cDTC).
Results: Two-way analyses of variance showed the main effect of cognitive task yielded anFratio ofF((4, 268))= 72.35,p< 0.01, for mean gait velocity, and anFratio ofF((4, 304))= 17.12,p< 0.001, for mDTC, indicating that the mean velocity was significantly lower and the mDTC significantly higher for DS_B (mean = 1.27, SD = 0.03, and mean = 13.52, SD = 1.28, respectively). The main effect of cognitive task yielded anFratio ofF((4, 116))= 84.32,p< 0.001, with the lowest average accuracy for DS_B (mean = 43.95, SD = 3.33); no effect was found for cDTC. In pwMSs, the EDSS accounted for 28% (F= 13.65,p= 0.001) of variance in a model predicting the highest mDTC.
Conclusions: Overall, among different cognitive tasks added, the Digit Span backward was the most interfering cognitive task over gait velocity and accuracy. The effect was similar independently from the motor complexity and the group. PwMSs and HCs behaved in a similar manner at all motor complexity levels and during all cognitive task
Accelerated Trajectories of Walking Capacity Across the Adult Life Span in Persons With Multiple Sclerosis: An Underrecognized Challenge
No full textBackground. In the general population, trajectories of walking capacity is accelerated and nonlinear with advanced age. Whether this is more pronounced in persons with multiple sclerosis (pwMS), along with the prevalence of dismobility (ie, slow gait speed), are currently unknown. Our objective was to investigate trajectories of walking capacity and prevalence of dismobility across the adult life span in pwMS versus healthy controls (HC). Methods. Data on maximal timed 25-foot walk test (T25FWT), 2-minute walk test (2MWT), and 6-minute walk test (6MWT) along with prevalence of dismobility were assembled from 2 RIMS multicenter studies (n = 502 pwMS; age range 21-77 years, 6 age groups: 20-29, 30-39, 40-49, 50-59, 60-69, and 70-79 years). HC data were extracted from studies containing normative reference values (n = 1070-3780 HC). Results. Age trajectories of walking capacity was nonlinear and accelerated in pwMS versus HC. While measures of walking capacity in pwMS were suppressed already early in life, the gap between pwMS and HC significantly widened across the 6 age groups (pwMS performed 64%, 70%, 57%, 59%, 51%, and 37% of HC, respectively). This coincided with high prevalences of dismobility in pwMS across the 6 age groups when using usual gait speed cut-point values <1.0 m/s (corresponding to 33%, 32%, 51%, 59%, 75%, and 100%) and <0.6 m/s (corresponding to 19%, 12%, 26%, 23%, 33%, and 43%), markedly exceeding that observed in HC. Conclusion. The present data on walking capacity provide evidence for an accelerated deterioration in pwMS with advanced age, coinciding with high prevalences of dismobility (ie, slow gait speed).The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was partially funded via an unrestricted educational grant from Novartis Pharma AG to Rehabilitation in Multiple Sclerosis, the European network for best practice and research in MS rehabilitation (eurims.org).Hvid, LG (reprint author), Aarhus Univ, Sect Sport Sci, Dept Publ Hlth, Dalgas Ave 4, DK-8000 Aarhus C, Denmark.
[email protected]
Validity of mobility measures in multiple sclerosis, according disability level: a RIMS multi-center study.
No full textValidity and floor/ceiling effects of upper limb outcome measures in people with Multiple Sclerosis: an European RIMS multi-center study
No full textThis study is part of a multi-center study that took place within the European Rehabilitation In Multiple Sclerosis (RIMS) Network- Special Interest Group (SIG) on Occupation (www.eurims.org). The primary aim of this RIMS multi-center study was to investigate the psychometric properties (reliability, validity, responsiveness and floor/ ceiling effect) of upper limb outcome measures in persons with Multiple Sclerosis (PwMS). This master thesis will only report on the validity and possible floor/ ceiling effects
Predicting habitual walking in persons with Multiple Sclerosis: associations with cognitive-motor interference, mobility, cognition and quality of life
No full textAbstract
BACKGROUND: Habitual walking is often affected in pwMS but there is little knowledge about the association of habitual walking with other factors like dual task capacity, mobility, quality of life or cognitive abilities.
OBJECTIVES: Investigate the predictability of habitual walking by steps/day in pwMS.
PARTICIPANTS: 45 pwMS with an EDSS score between two and five were recruited in different centers in Italy, Israel, and Belgium.
MEASUREMENTS: The outcome measures are divided into the categories mobility, cognition, cognitive-motor interference and quality of life. Habitual walking was the primary outcome measure. The outcome measures existed out of questionnaires, performance scales, and the Yamax pedometer.
RESULTS: The DGI is the most predicting factor for habitual walking. In general, mobility outcome measures are the most correlated with habitual walking. For the cognition, motor-cognitive interference and quality of life outcome measures none of the factors correlated to habitual walking.
CONCLUSION: In persons with mild MS, habitual walking can be predicted by the DGI with an RSquare score of 0,34. This model predicts only a small part, there could be several other factors that are not investigated in this study, but that have an influence on habitual walking. More research is necessary on bigger and more diverse samples, with older and more severely disabled patients, including more possible influencing factors
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