1,332 research outputs found
Imperium e sacerdotium. Il contesto storico di Dante Alighieri
No full textNel saggio si ripercorre il contesto storico nazionale ai tempi di Dante, individuando in due date i termini "ante quem" e "post quem" del periodo di nostro interesse: il 1252, quando Firenze iniziò a battere moneta e il 1333, quando una disastrosa alluvione mise in ginocchio la città.
È in questo arco temporale che tenteremo di contestualizzare l’azione politica, che portò in Italia personaggi come Bertrando del Poggetto, volta a combattere il ghibellinismo e ricostruire lo Stato della Chiesa. I loro nomi sono legati alla lotta contro l’imperatore Ludovico il Bavaro e, Dante era un grande sostenitore dell’istituzione monarchica imperiale e, per questo, considerato demolitore del governo papale e dei cardinali che ne erano i rappresentanti. È in quegli anni che giunge a un punto di svolta la contrapposizione fra papato e impero e si delinea, per poi affermarsi, l’assetto politico di tipo oligarchico, con al governo le ricche famiglie borghesi
Tractatus de balneis thermarum ferinarum (vulgo Wildbaden)
No full textKolophon, Bl. B₅ verso: "Impressum Tubinge per Thomam Anshelmum anno [et]C.XIII. [=1513]"Bogensignaturen: A⁴, B
Regimen durch den hochgelerten und übertreffenlichen der Artzney Doctor Johann Wydman, genant Möichinger, gesetzt, wie man sich in pestilentzischem Lufft halten soll
No full textKolophon auf Bl. c₈ recto: Geendet und getruckt zů Strassburg als man zalt nach der Geburt Christi. M.D.XIX.Bogensignaturen: a⁸, b⁴, c⁸Titelholzschnit
Stimulation of osteoclast activity by low B-vitamin concentrations
No full textBackground: Homocysteine (HCY) has recently been linked to fragility fractures. Moreover, HCY activates osteoclasts (OC). Elevated HCY concentrations are mainly caused by folate, vitamin B12 (B12) and B6 (B6) deficiencies. We hypothesized that folate, B12 and B6 deficiencies stimulate OC activity. Materials and methods: OC were cultured from peripheral blood mononuclear cells (10 healthy male donors, 34 ± 5 years) for 20 days. Culture medium was conditioned with decreasing concentrations of folate, B12 and B6 (in combination or variation of only one vitamin) starting at physiologic concentrations. Moreover, we tested increasing concentrations of HCY. OC activity was measured by dentine resorption activity (DRA), tartrate-resistant acid phosphatase (TRAP) and cathepsin K (CK) activity. Results: The combined reduction of folate, B12 and B6 stimulated DRA up to 211% (p < 0.001). This observation was confirmed by TRAP (maximum increase 24%, p < 0.001) and CK (maximum increase 24%, p < 0.001). Reduction of only one vitamin stimulated DRA up to 250% (folate: maximum increase 248%, p < 0.018; B12: maximum increase 252%, p < 0.001, B6: maximum increase 247%, p < 0.001). However, only for folate this effect could be confirmed by TRAP (maximum increase 33%, p < 0.001). HCY stimulated DRA up to 395% (p < 0.001). TRAP (maximum increase 49%, p < 0.001) and CK analyses confirmed this observation (maximum increase 50%, p < 0.001). Conclusion: Our results demonstrate a strong stimulatory effect of low concentrations of folate, B12 and B6 on OC activity, suggesting a mechanistic role of low B-vitamin concentrations for bone degradation. Consequently, OC stimulation by low folate, B12 and B6 concentrations could be an important adverse factor for bone health. © 2007 Elsevier Inc. All rights reserved
Fortbestehensprognose
No full textGroß PJ, Amen M. Fortbestehensprognose. In: Auge-Dickhut S, Moser U, Widmann B, eds. Praxis der Unternehmensbewertung. Vol Loseblatt, 16. Journal, Dezember 2004, Abschnitt 5.9. München: Olzog Verlag; 2004: 1-52
A contribution to the Italian adaptation of the Destructive-Constructive Leadership Questionnaire
No full textThe study aimed to supply a preliminary contribution to the adaptation of the Destructive-Constructive Leadership Questionnaire (DCL; Ekvall & Arvonen, 1991; Aasland et al., 2010) to the Italian context. The scale, comprising 22 items across 5 dimensions, may represent a comprehensive measure of both negative leadership – such as Tyrannical, Derailed, Supportive-Disloyal, Laissez-faire behaviors – as well as positive leadership, that is Constructive behavior.
The study was carried out with 1230 participants (age: M = 41.75; SD =11.13), both men and women, employed for at least one year at the time of data collection (March-June, 2014). The research questionnaire include the DCL scale, a 5-item measure of Job Satisfaction (Brayfield & Rothe, 1951) and some socio-demographic questions, such as gender, age, level of education, seniority.
Results of a CFA performed via LISREL supported the goodness of fit of the 5 factor model (RMSEA = .03, CFI = .99). Reliability estimates by means of Cronbach’s alpha were acceptable and ranged between .63 to .84. A positive correlation emerged between the measure of Job Satisfaction and that of Constructive leadership. Conversely, the satisfaction measure had a negative connection with Destructive leadership, in line with theoretical assumptions.
The DCL could be a useful tool both for scholars and practitioners who want to detect different facets of leadership behaviors in applied empirical research or intervention, be it positive or negative facets. This is something that already existing leadership inventories rarely offer
Accumulation of homocysteine by decreasing concentrations of folate, vitamin B12 and B6 does not influence the activity of human osteoblasts in vitro
No full textBackground: Homocysteine (HCY) has recently been linked to fragility fractures. Elevated circulating HCY is mainly caused by folate, vitamin B12 and B6 deficiencies. However, little is known about the effect of these vitamins on the activity of osteoblasts. We hypothesized that decreasing concentrations of folate, vitamin B12 and B6 decrease osteoblasts activity by accumulation of HCY. Methods: Osteoblasts obtained from trabecular human bone specimens of 8 donors were cultured with decreasing concentrations of folate, vitamin B12 and B6. Vitamin concentrations were modified in combination or one vitamin only (8 repetitions × 8 donors, n = 64). After 14 days alkaline phosphatase (AP) activity, pro-collagen type I N-terminal peptide (PINP) and osteocalcin secretion in the supernatant was measured. After 20 days, the formation of mineralized matrix was analyzed. Results: Decreasing B-vitamin concentrations induced a significant accumulation of HCY in the supernatant reaching up to 160%. The increase in HCY was not accompanied by changes of AP, osteocalcin and PINP. Moreover, mineralized matrix formation was not affected. Conclusion: Accumulation of HCY by decreasing concentrations of folate, vitamin B12 and B6 does not affect the activity of human osteoblasts. Consequently, other mechanisms have to be responsible for the reduced bone quality in hyperhomocysteinemic subjects. © 2007 Elsevier B.V. All rights reserved
The role of hyperhomocysteinemia as well as folate, vitamin B6 and B12 deficiencies in osteoporosis - A systematic review
No full textHyperhomocysteinemia (HHCY) has been suggested as a new risk factor for osteoporosis. Recent epidemiological, clinical and experimental studies provide a growing body of data, which is reviewed in this article. Epidemiological and (randomized) clinical trials suggest that HHCY increases fracture risk, but has minor effects on bone mineral density. Measurement of biochemical bone turnover markers indicates a shift of bone metabolism towards bone resorption. Animal studies confirm these observations showing a reduced bone quality and stimulation of bone resorption in hyperhomocysteinemic animals. Homocysteine (HCY) has been found to accumulate in bone by collagen binding. Cell culture studies demonstrate that high HCY levels stimulate osteoclasts but not osteoblasts, indicating again a shift of bone metabolism towards bone resorption. Regarding B-vitamins, only a few in vivo studies with equivocal results have been published. However, two large cell culture studies confirm the results obtained with exogenous HCY administration. In addition, HHCY seems to have adverse affects on extracellular bone matrix by disturbing collagen crosslinking. In conclusion, existing data suggest that HHCY (and possibly B-vitamin deficiencies) adversely affects bone quality by a stimulation of bone resorption and disturbance of collagen crosslinking. © 2007 by Walter de Gruyter
A recurring packing contact in crystals of InlB pinpoints functional binding sites in the internalin domain and the B repeat
No full textGeerds C, Bleymüller WM, Meyer T, Widmann C, Niemann H. A recurring packing contact in crystals of InlB pinpoints functional binding sites in the internalin domain and the B repeat. Acta Crystallographica Section D : Structural Biology . 2022;78( 3):310-320.InlB, a bacterial agonist of the human receptor tyrosine kinase MET, consists of an N-terminal internalin domain, a central B repeat and three C-terminal GW domains. In all previous structures of full-length InlB or an InlB construct lacking the GW domains (InlB392), there was no interpretable electron density for the B repeat. Here, three InlB392 crystal structures in which the B repeat is resolved are described. These are the first structures to reveal the relative orientation of the internalin domain and the B repeat. A wild-type structure and two structures of the T332E variant together contain five crystallographically independent molecules. Surprisingly, the threonine-to-glutamate substitution in the B repeat substantially improved the crystallization propensity and crystal quality of the T332E variant. The internalin domain and B repeat are quite rigid internally, but are flexibly linked to each other. The new structures show that inter-domain flexibility is the most likely cause of the missing electron density for the B repeat in previous InlB structures. A potential binding groove between B-repeat strand beta2 and an adjacent loop forms an important crystal contact in all five crystallographically independent chains. This region may represent a hydrophobic `sticky patch' that supports protein-protein interactions. This assumption agrees with the previous finding that all known inactivating point mutations in the B repeat lie within strand beta2. The groove formed by strand beta2 and the adjacent loop may thus represent a functionally important protein-protein interaction site in the B repeat. open access
Three clarinet pieces by Jörg Widmann from a performer's view: Fantasie for Clarinet Solo, Fünf Bruchstücke for Clarinet and Piano, and Nachtstück for Clarinet, Cello and Piano
No full textThis
project
is
a comprehensive study of
the
early clarinet
compositions
by Jörg Widmann
(b. 1973). It includ
es
Fantasie
for Clarinet Solo
(1993, rev. 2001),
Fünf Bruchstücke
for Clarinet
and Piano
(1997), and
Nachtstück
for Clarinet, Cello and Piano
(1998). The project
provides
background information on
each composition
with analysis from the perspective of a performer,
aiming to understand and overcome
challenges by giving
specific performance technique
suggestions and
practice guidelines.U of I OnlySchool of Music polic
- …
