50 research outputs found
Depression in blepharospasm: a question of facial feedback?
No full textJanis Rebecca Bedarf,1 Sied Kebir,1,2 Joan Philipp Michelis,1,3 Bettina Wabbels,4 Sebastian Paus1 1Department of Neurology, University of Bonn, Bonn, 2Department of Neurology, University of Essen, Essen, Germany; 3Movement Disorders Center, Department of Neurology, Bern University Hospital, Bern, Switzerland; 4Department of Ophthalmology, University of Bonn, Bonn, Germany Abstract: Depression is the most important nonmotor symptom in blepharospasm (BL). As facial expression influences emotional perception, summarized as the facial feedback hypothesis, we investigated if patients report fewer depressive symptoms if injections of botulinum neurotoxin (BoNT) include the “grief muscles” of the glabellar region, compared to treatment of orbicularis oculi muscles alone. Ninety BL patients were included, half of whom had BoNT treatment including the frown lines. While treatment pattern did not predict depressive symptoms overall, subgroup analysis revealed that in male BL patients, BoNT injections into the frown lines were associated with remarkably less depressive symptoms. We hypothesize that in BL patients presenting with dystonia of the eyebrow region, BoNT therapy should include frown line application whenever justified, to optimize nonmotor effects of BoNT denervation. Keywords: botulinum neurotoxin, blepharospasm, depression, facial feedback, frown lines, grief muscle
Sexual dysfunction in cervical dystonia and blepharospasm
No full textM Marek,1 M Grobe-Einsler,1 JR Bedarf,1 B Wabbels,2 S Paus1 1Department of Neurology, University of Bonn, Bonn, Germany; 2Department of Ophthalmology, University of Bonn, Bonn, Germany Background: Sexual dysfunction is a frequent, yet underrated, symptom of neurological disease. While knowledge of non-motor comorbidity in focal dystonia is growing rapidly, there is no information on the prevalence of sexual dysfunction in cervical dystonia (CD) or blepharospasm (BL). Methods: In this controlled study, we examined sexual dysfunction in 65 patients with CD and 54 patients with BL by the Arizona Sexual Experience Scale, a validated self-rating scale. Results: Sexual dysfunction was significantly higher in CD patients (45%) than in controls (24%), and frequent in BL (39%). Interestingly, variables of dystonia such as disease duration or severity did not influence sexuality; yet, 23% of CD patients ascribed worsening of their sexual life to dystonia. Symptoms of depression were identified as the most important predictors for sexual dysfunction, followed by age, and personal status (single). Conclusion: Our observations establish sexual dysfunction as a frequent non-motor symptom in CD and BL that is perceived as a burden. It should be considered when investigating patients with adult-onset focal dystonia. Keywords: dystonia, cervical dystonia, blepharospasm, sexual dysfunction, depression 
Wenn die Mitochondrien streiken - Ptosis, Augenbewegungsstörungen und Optikopathien als Folge mitochondrialer Erkrankungen
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Extending product lifetimes: a reuse network for ICT hardware
No full textThis paper examines how a network of small/medium-sized enterprises was developed to enable reuse and resource conservation in the information and communications technology sector by exchange of used equipment over a resource exchange internet platform. The network’s effectiveness and potential for expansion is also examined. The results demonstrate that it is possible and in many cases economically viable to increase the reuse stream of equipment and to extend the network’s activities to a European level. The expectation of doubling the amount of traded appliances within the network was greatly exceeded. The successful development of technical, legal and financial guidance led to its incorporation into an accredited industry guideline
AltersabhängigeFehlerquoten bei der automatischen Rasterperimetrie mit hellen und dunklen Stimuli
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