2,438 research outputs found
An investigation into adaptive power reduction techniques for neural hardware
No full textIn light of the growing applicability of Artificial Neural Network (ANN) in the signal processing field [1] and the present thrust of the semiconductor industry towards low-power SOCs for mobile devices [2], the power consumption of ANN hardware has become a very important implementation issue. Adaptability is a powerful and useful feature of neural networks. All current approaches for low-power ANN hardware techniques are ‘non-adaptive’ with respect to the power consumption of the network (i.e. power-reduction is not an objective of the adaptation/learning process). In the research work presented in this thesis, investigations on possible adaptive power reduction techniques have been carried out, which attempt to exploit the adaptability of neural networks in order to reduce the power consumption. Three separate approaches for such adaptive power reduction are proposed: adaptation of size, adaptation of network weights and adaptation of calculation precision. Initial case studies exhibit promising results with significant power reduction
Biokinetics of buccal spray insulin in patients with type 1 diabetes
No full textMetabolism. 2005 Jul;54(7):930-4. Biokinetics of buccal spray insulin in patients with type 1 diabetes. Pozzilli P, Manfrini S, Costanza F, Coppolino G, Cavallo MG, Fioriti E, Modi P. Source Department of Endocrinoplogy and Diabetes, University Campus Bio-Medico, Rome, Italy. [email protected] Abstract OBJECTIVE: To evaluate the metabolic effect of buccal spray insulin compared with subcutaneous regular insulin in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: This study compared plasma glucose, insulin, and C-peptide levels in 18 patients with type 1 diabetes treated with subcutaneous regular or buccal spray insulin on 2 consecutive mornings. On day 1, patients were treated with their usual subcutaneous regular insulin regimens. On day 2, patients received buccal spray insulin. In the morning of both days 1 and 2, patients received a standard meal of 630 kJ. No intermediate or long-acting insulin was administered to patients on the morning of the test. Blood samples were collected for up to 4 hours for biokinetic analysis. In a subset of 3 patients, premeal buccal spray insulin was administered for 2 entire consecutive days. In these patients, glucose levels were monitored using the glucose sensor monitoring system. RESULTS: Overall, there were no statistically significant differences in glucose, insulin, or C-peptide levels measured after administration of subcutaneous vs buccal spray insulin. However, at 90 and 120 minutes after subcutaneous regular insulin administration, significantly higher insulin levels and more prolonged hypoglycemic effect were detected compared with buccal spray insulin administration. In the 3 patients who received 1 day of regular and 2 entire days of buccal spray insulin, no significant differences were observed in glucose levels during the 3 days of glucose sensor monitoring. CONCLUSIONS: Insulin administered via the buccal spray formulation is as effective as the subcutaneous route in lowering blood glucose levels
A critique of the Brahmasūtra (III. 2. 11-IV) (with special reference to Śankarācārya's commentary) /
No full text2. System of the Sutras (III. 2. 11-IV
Psychological treatments in schizophrenia: II. Meta-analyses of randomized controlled trials of social skills training and cognitive remediation
No full textBackground. Social skills training and cognitive remediation are psychological techniques with considerable face validity for the treatment of negative symptoms of schizophrenia and their consequences. This paper provides a meta-analytical review of these treatments. It includes an appreciable number of randomized controlled trials, using comparisons against both standard care and other active interventions. However, the assessment of particular outcomes sometimes had to be based on single studies.Method. A detailed search strategy was used to identify randomized controlled trials of social skills training and cognitive remediation, primarily employing electronic databases. Randomized controlled trials (RCTs) that met predefined criteria were then subjected to meta-analysis on a variety of outcome measures.Results. There was no clear evidence for any benefits of social skills training on relapse rate, global adjustment, social functioning, quality of life or treatment compliance. Cognitive remediation had no benefit on attention, verbal memory, visual memory, planning, cognitive flexibility or mental state.Conclusions. Social skills training and cognitive remediation do not appear to confer reliable benefits for patients with schizophrenia and cannot be recommended for clinical practice
Cast in-situ Cu-TiC Composites: Synthesis by SHS Route and Characterization
No full textThe present investigation discusses observations pertaining to the synthesis of Cu-based composites containing TiC particles in the range of 45–50 volume % by self-propagating high temperature synthesis (SHS) process. A composite with 11–13 volume % TiC dispersion was also synthesized through remelting and dilution. The composites were observed to contain a copper matrix together with a Cu–Ti intermetallic\ud
compound, TiC dispersoid particles and partially reacted graphite. The regions showing partially reacted graphite (carbon) became less prominent in the diluted omposites. Al addition led to the refinement of TiC particles, higher hardness, reduced density and improved degree of formation and better homogeneity of the distribution of TiC particles. Dilution caused reduced hardness, while the density followed a reverse trend
El populismo hinduista de Narendra Modi: reimaginando la nación india
No full textEste artículo analiza el impacto que el populismo del actual primer ministro Narendra Modi está teniendo sobre la democracia india. Nuestro análisis defiende que el populismo ha sido una herramienta útil en la profundización democrática en la India. La apelación al «pueblo», como construcción política de amplia base social, ha ayudado a transcender las tradicionales divisiones identitarias. Frente a esa tradición de populismo transversal e incluyente, el artículo examina la versión actual de Modi que, por el contrario, se construye sobre un exclusivismo hinduista. Dicha narrativa excluyente hace peligrar el contrato social nacido de la idea de la India como unidad en la diversidad.Palabras clave: India, Narendra Modi, Indira Gandhi, populismo, secularism
Factors predicting a good symptomatic outcome after Prostate Artery Embolisation (PAE)
No full textINTRODUCTION: As prostate artery embolisation (PAE) becomes an established treatment for benign prostatic obstruction, factors predicting good symptomatic outcome remain unclear. Pre-embolisation prostate size as a predictor is controversial with a handful of papers coming to conflicting conclusions. We aimed to investigate if an association existed in our patient cohort between prostate size and clinical benefit, in addition to evaluating percentage volume reduction as a predictor of symptomatic outcome following PAE.MATERIALS OR METHODS: Prospective follow-up of 86 PAE patients at a single institution between June 2012 and January 2016 was conducted (mean age 64.9 years, range 54-80 years). Multiple linear regression analysis was performed to assess strength of association between clinical improvement (change in IPSS) and other variables, of any statistical correlation, through Pearson's bivariate analysis.RESULTS: No major procedural complications were identified and clinical success was achieved in 72.1% (n = 62) at 12 months. Initial prostate size and percentage reduction were found to have a significant association with clinical improvement. Multiple linear regression analysis (r2 = 0.48) demonstrated that percentage volume reduction at 3 months (r = 0.68, p < 0.001) had the strongest correlation with good symptomatic improvement at 12 months after adjusting for confounding factors.CONCLUSION: Both the initial prostate size and percentage volume reduction at 3 months predict good symptomatic outcome at 12 months. These findings therefore aid patient selection and counselling to achieve optimal outcomes for men undergoing prostate artery embolisation.</p
Identifying predictive markers for survival in malignant biliary obstruction following percutaneous transhepatic biliary drainage
No full textAim: malignant biliary obstructive disease is commonly managed with percutaneous transhepatic biliary drainage (PTBD). Traditionally, outcomes are evaluated collectively despite substantial variability in the underlying aetiology and extent of disease. The purpose of this study was to investigate whether variability in survival could be explained by different underlying patient and disease factors. Materials and methods: a single centre, retrospective study was performed looking at first-time malignant PTBD and respective survival outcomes between 2017- 2021. Survival censoring was taken as June 2022. Predictors included aetiology, age, preprocedural serum haemoglobin, and bilirubin. Subgroups were dichotomised with respect to median values. Kaplan–Meier survival analysis and the log rank test were used for univariate analysis and Cox proportional hazards regression for multivariate analysis. Results: one hundred fifty-six patients were identified, including 62 pancreatic, 19 ampullary/duodenal, 55 hilar cholangiocarcinoma, and 20 non hepatobiliary cancers. Median overall survival for the entire cohort was 136 days. The underlying aetiology significantly impacted median survival with non-hepatobiliary obstruction faring the worst; 53 days, and was in stark contrast to cholangiocarcinoma (347 days, p < 0.001). On multivariate analysis, we found that in addition to aetiology, patients > 70 years, preprocedural haemoglobin (< 110) and bilirubin (> 232) were all independent prognosticators and had significantly worse survival (HR 1.2, 1.8, 1.6, and 1.4, respectively, all p < 0.05). Conclusion: age, underlying malignant aetiology, preprocedural haemoglobin, and bilirubin were identified as independent predictors of post-PTBD survival. Careful patient selection may therefore improve patient outcomes following PTBD.</p
Once-daily nepafenac ophthalmic suspension 0.3% to prevent and treat ocular inflammation and pain after cataract surgery: Phase 3 study
No full textPurposeTo evaluate once-daily nepafenac 0.3% to prevent and treat ocular pain and inflammation after cataract surgery.SettingSixty-five centers in the United States and Europe.DesignRandomized double-masked vehicle- and active-controlled phase 3 study.MethodsPatients received nepafenac 0.3% once daily, nepafenac 0.1% 3 times daily, or their respective vehicles from day −1 to day 14 after cataract extraction. An additional drop of study drug was administered 30 to 120 minutes preoperatively. The primary endpoint was the percentage of patients with a cure for inflammation (score of 0 for both aqueous cells and flare) at day 14.ResultsOf randomized patients, 817 received nepafenac 0.3%, 819 received nepafenac 0.1%, and 200 and 206 received the respective vehicles. Significantly more nepafenac 0.3% patients had no inflammation (68.4% versus 34.0%) and were pain free (91.0% versus 49.7%) at day 14 than vehicle patients (both P<.0001). Nepafenac 0.3% was noninferior to nepafenac 0.1% for inflammation (95% confidence interval [CI], −5.73% to 3.17%) and pain-free rates (95% CI, −3.08% to 2.70%). At all postoperative visits, fewer treatment failures (P≤.0012) and more clinical successes (P≤.0264) were observed with nepafenac 0.3% versus vehicle. Nepafenac 0.3% was well tolerated and had a safety profile comparable to that of nepafenac 0.1%.ConclusionsOnce-daily nepafenac 0.3% was noninferior to nepafenac 0.1% 3 times daily for prevention and treatment of ocular inflammation and pain following cataract surgery. The safety of nepafenac 0.3% was comparable to that of nepafenac 0.1%, with the added convenience of once-daily dosing.Financial DisclosureDrs. Modi, Lehmann, Walters, Fong, Christie, Roel, Nethery, and Reiser have been paid consultants to Alcon Research, Ltd. Ms. Sager is an employee of Alcon Research, Ltd. Drs. Tsorbatzoglou, Philipson, and Traverso have no financial or proprietary interest in any material or method mentioned
Power scalable implementation of artificial neural networks
No full textAs the use of Artificial Neural Network (ANN) in mobile embedded devices gets more pervasive, power consumption of ANN hardware is becoming a major limiting factor. Although considerable research efforts are now directed towards low-power implementations of ANN, the issue of dynamic power scalability of the implemented design has been largely overlooked. In this paper, we discuss the motivation and basic principles for implementing power scaling in ANN Hardware. With the help of a simple example, we demonstrate how power scaling can be achieved with dynamic pruning techniques
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