260 research outputs found
Refrigerator
No full textThe ornamental design of a refrigerator as shown and described.
[0001] 1. Refrigerator
[0002] 1.1 Front perspective view with the door in the open position;
[0003] 1.2 Front perspective view with the door in the close position;
[0004] 1.3 Front view with the door in the open position;
[0005] 1.4 Rear view with the door in the open position; and
[0006] 1.5 : Right side view
[0007] 1.6 : Left side view
[0008] 1.7 Top view with the door in the open position
A randomized prospective study of intravesical prophylaxis in non-musle invasive bladder cancer at intermediate risk of recurrence: mitomycin chemotherapy vs BCG immunotherapy
No full textOBJECTIVE: The present study compared the therapeutic activity of intravesical BCG with intravesical mitomycin C chemotherapy in patients with non-muscle invasive bladder cancer at intermediate risk of recurrence in a prospective randomised trial. METHODS: 96 patients with low grade recurrent non-muscle invasive bladder cancer (Ta or T1) were randomly assigned to intravesical treatment with BCG or mitomycin C. RESULTS: The follow up ranged from 12 to 108 months (mean 65.7+/-25.6 months). Half of the patients were free of recurrence respectively after mitomycin C (23/46) and BCG (23/46) treatment. Recurrences after BCG presented in the first 6 month period (> 50%) or in the long term follow up (> 3 years) whereas early ( 3 years) recurrences after MMC treatment were less frequent. Time to recurrence in the MMC arm was 17.5+/-15.4 and in the BCG arm 21.9+/-24.8 (p = 0.47). None progressed to muscle-invasive tumour or underwent cystectomy during the observation period. MMC caused grade 1-2 toxicity in 11 patients (mild or moderate cystitis in 6 and mild or moderate hypersensitivity reactions in 5) and grade 3 toxicity in 11 patients (severe cystitis in 4, gross haematuria in 2 and severe hypersensitivity in 5 cases). Nineteen of the BCG treated patients had grade 1-2 toxicity (mild to moderate cystitis or prostatitis in 17, mild fever and myalgia in 2) and 3 developed grade 3 toxicity (severe cystitis in 2 patients and epididymitis that led to the necessity of antituberculous therapy in one patient). Intravesical treatment was discontinued in 11 patients under MMC treatment and in 2 patients under BCG treatment (p = 0.008). CONCLUSIONS: Both MMC and BCG demonstrate efficacy in prolonging the time to recurrence with respect to the period of observation before treatment, so reducing the hospitalisation rate for TUR of the recurrent tumours, but no difference in the recurrence rates was observed between MMC and BCG as primary treatment. A significant number of patients treated with MMC suffered cystitis or hypersensitivity reactions so severe to cause discontinuation of the treatment. The vast majority of patients treated with BCG had only mild or moderate side effects under BCG treatment but a serious infection was observed in one case requiring antituberculous treatmen
Docetaxel ed estramustina nel carcinoma prostatico ormonoresistente: rapporto preliminare
No full text
Conservative treatment of renal cell carcinoma : framework, incidence and classification
No full textRecent interest in nephron sparing surgery for renal cell carcinoma has been stimulated by advances in diagnostic imaging, following an increasing number of incidentally discovered low stage renal cell carcinoma and good long term survival in patients undergoing this form of treatment. Tosaka et al reported a 5-years survival of 94.7% in patients with incidental renal cell carcinoma compared with 60.9% in diagnosed because symptomatic. Along with a diagnosis of carcinoma more and more premature, a whole string of little lesions is present, not easily identifiable by the recent diagnostic imaging. Tosaka and others examined renal lesions going by the ultrasonography as a check-up or as a first frame in patients suffering from microscopic hematuria; they proved that neoplastic lesions represent 5.4% of all the masses identifiable by diagnostic imaging. The frequent discovery of limited carcinoma, the difficulty in the diagnostic attribution and demonstration of the good survival of patients who were treated by a nephron sparing surgery, added to the one of patients undergone to radical nephrectomy, caused an interest in nephron-sparing surgery for incidental renal carcinoma also for patients with normal controlateral kidney and not very extended tumors, usually in peripheral sites. At the moment record of cases concerning nephron sparing surgery is quite limited, any way it shows a survival equal to 90% with only two local recurrences, reported only in one experience and caused by an incomplete resection or by multicentric neoplastic lesions
Body mass index e variabili patologiche in soggetti sottoposti a prostatectomia radicale
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