1,720,967 research outputs found
Sintesi di Derivati Monosaccaridici quali Modelli per Studi di Funzionalizzazione di Glicopolimeri Nanostrutturati
No full textSintesi di un monomero stirenico derivato dal D-galattosio precursore di glicopolimeri nanostrutturati
No full textUnexpected influence of a remote 5-substituent on the lithiation of the 1,3-dithiane ring
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Synthesis of crosslinked nanostructured saccharidic vinyl copolymers and their functionalization
No full textSaccharidic monomers and a macromonomer were synthesized and copolymerized in the presence of divinylbenzene (DVB) as crosslinker in conditions of separation of phases to give hydrophilic nanostructured sugar-based vinyl copolymers. Appropriate model molecules such as N-benzyl-D-gluconamide for the saccharidic copolymers and 4-(4-chlorobutoxy)benzaldehyde and (E)-4-(4-chloro-2-butenyloxy) benzaldehyde for electrophilic reagents prefiguring possible copper amine oxidase inhibitors allowed identification of conditions for useful monofunctionalizations mainly at the position 2 of the saccharidic units. The examined samples of the nanostructured copolymers from one of the monomers proved to be stable enough to tolerate the functionalization reactions without loss of morphology
Synthesis of a D-galactose derivative and its functionalization at the anomeric center with benzylamine residues as a model system for biologically active glycopolymers
No full textNanostructured styrenic copolymers containing glucopyranosyl residues and their functionalization
No full textSugar-based co-polymers with saccharidic units in stable cyclic form and nanometric morphologies stabilized through crosslinking, adaptable through specific functionalizations to biochemical interaction studies with copper-containing amine oxidases, were synthesized from appropriate monomers and macromonomers. The most promising nanospherical co-polymer obtained, containing b-D-glucopyranosidic units, was employed in functionalization reactions with the help of model molecules, achieving useful transformations mainly at the 6-position and to a minor extent at the 2-position of the saccharidic system
Polymer-supported Synthesis of α- and ß-Hydroxyketones through the Formation of 1,3-Dithiane Intermediates
No full textThe synthesis of polymer-supported 2-monosubstituted 1,3-dithianes from soluble copolymers bearing 1,3-propanedithiol groups, their lithiation, reactions with electrophiles such as aldehydes, ketones also alpha,beta-unsaturated and oxiranes, and cleavage of the produced dithioketal-protected alpha- or beta-hydroxyketones with various reagents have been studied
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