4,385 research outputs found
Portrait of Geoffrey Dutton.
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/300832Portrait of Geoffrey Dutton.
Inscription: Portrait of Geoffrey Dutton.206835
Item: [2005.0004.00010] "Portrait of Geoffrey Dutton.
Margaret B. Freeman, The unicorn tapestries (Distribution Dutton and Co.)
No full textSalet Francis. Margaret B. Freeman, The unicorn tapestries (Distribution Dutton and Co.). In: Bulletin Monumental, tome 136, n°1, année 1978. pp. 104-106
Memorial of Mrs. Harriet Dutton : wife of Samuel W.S. Dutton, pastor of the North Church, New Haven, Conn.
No full text"Printed for the family."Address at the funeral of Mrs. Dutton, in the North Church, New Haven / Samuel Buckingham -- Address by Rev. Dr. Bacon -- Address at the grave / William B. Clarke -- Sermon preached in the North Church, New Haven, July 1, 1864, the second sabbath after Mrs. Dutton's death / Samuel W.S. Dutton.Mode of access: Internet.BEIN 2000 2389 58: Original front wrapper bound in. No. 11 of 23 works bound together with binder's title: Biographical pamphlets
First motorist Adelaide to Darwin 1907
No full textMS in pencil on back of b&w reproduction of postcard: "First motorists, Adelaide-Darwin, 1907. H.H. Dutton (driving) and Murray Aunger in 12-16 HP Talbot car which reached Tennant Creek and was abandoned. In 1908 a 24 HP Talbot car was driven by Messrs Dutton and Aunger from Adelaide (30 June 1908) to Darwin (20 August 1908). The 12-16 HP Talbot car being repaired en route and driven on to Darwin. Photo shows the 12-16 HP Talbot at the Criterion Hotel, Quorn, South Australia en route to Tennant Creek in 1907. Photo reproduction by E.L. Walpole." A crowd of men and boys looks on from the footpath.Unknow
A. P. Dutton photograph
No full textPhotograph of A. P. Dutton (b. 1822), who was an agent of the Underground Railroad in Racine, Racine County, Wisconsin. The image was collected by Ohio State University professor Wilbur H. Siebert (1866-1961). Siebert began researching the Underground Railroad in the 1890s as a way to interest his students in history
Marriage record of Lowe, Jefferson T. and Dutton, B. E.
No full textMarriage license for Jefferson T. Lowe and B.E. Dutton. D.A. Cole was the officiant
Possession (1) : an international exhibition of contemporary art
No full textCatalogue for the exhibition of the same name co-curated by Brian Curtin and Steve Dutton
Investigating the role of the B-cell receptor in mantle cell lymphoma
No full textMantle cell lymphoma (MCL) is a mature B-cell lymphoma typically characterised by the expression of cluster of differentiation 5 (CD5) and a t(11;14) translocation resulting in overexpression of cyclins. MCL displays significant morphological and clinical heterogeneity. Like chronic lymphocytic leukaemia (CLL), MCL can be divided into two subsets based upon immunoglobulin heavy chain variable (IGHV) region status: the more common unmutated (U-) IGHV and less common mutated (M-) IGHV subset. It has been suggested that, like in CLL, IGHV status informs different origin and clinical behaviour, with U-MCL being of pre-germinal centre (pre-GC) origin and aggressive clinical behaviour and M-MCL of post-GC origin and indolent course.In CLL, B-cell receptor (BCR) levels and signalling capacity have also helped to define subgroups with important clinical and biological significance. This thesis aimed to extend investigations to the BCR of MCLs and understand if BCR expression and signalling variation in MCL could affect variation in clinical behaviour.A cohort of thirty-six MCL cases were assessed for immunogenetic, phenotypic and functional characteristics including signalling capacity. IGHV3-21 and 4-34 were equally identified in U-MCL whilst IGHV4-34 was most common in M-MCL. Fifty percent (%) had an U-IGHV (>98% homology to germline). Surface immunoglobulin (sIg) M was expressed variably but significantly higher in conventional, nodal MCL (p=0.01) and non-aggressive U-MCL (p=0.03) than in leukaemic non-nodal (LNN) or M-MCL.Surface IgM (sIgM) expression was higher in MCL than in CLL (p<0.01). Mean signalling capacity was significantly higher in MCL than CLL (p<0.01), and correlated positively with sIgM expression. A subgroup of MCL had low signalling capacity similar to CLL. This ‘CLL-like’ signalling group was composed predominantly of LNN MCL and IGHV3-21 U-MCL with low sIgM expression. In contrast to high signalling MCL cases, this group had a CLL-like BCR engaged functional phenotype: recoverable sIgM expression in vitro, high basal proximal signalling kinases and an ‘activated’ glycosylation profile on the constant Ig region.MCL tissue and matched lymph node and peripheral blood samples were assessed. The lymph node compartment was identified as the likely site of engagement in non-aggressive MCL; sIgM levels were significantly lower in the lymph node than in the peripheral blood in all tissue and paired samples (p=0.03). Signalling capacity was also significantly lower in lymph node tissue samples (p<0.01). Lower sIgM levels in the lymph node may be indicative of site occurred antigen-induced endocytosis. M-MCL with low sIgM was associated with improved event-free survival (p=0.04).This study reveals that a proportion of MCL have a BCR engaged signature with low sIgM and low signalling capacity. This likely occurs in the lymph node compartment as a result of the influence of putative (super)antigen, with down-modulation of sIgM. This is particularly prominent in LNN M-MCL and may affect the balance between proliferation and anergy. This mirrors other mature B-cell malignancies, particularly CLL, where this interaction influences clinical outcomes
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