1,721,058 research outputs found
Designing Phygital Activities In a Smart Multisensorial Room: a Collaborative Cognitive Environment for Children with and without Disabilities
No full textTechnology integration in education has a great potential to transform learning paths, to overcome barriers and increase meaningful interactions among students, teachers, and the environment. Phygital learning is an emerging approach that balances the innovative technology-driven experience content with the traditional and physical one. In the context of Inclusive Education, this approach is particularly promising for enhancing the learning domains (cognitive, affective, and psychomotor) of children with disabilities. Recognized as integrators in multidisciplinary teams, characterized by a broad vision on users’ needs and experience, and familiar with the creative problemsolving process, designers can have an active role in developing new learning activities. This paper describes the development of Magika, an interactive Multisensory Environment, that supports inclusive education via playful phygital (physical + digital) activities for children with and without disabilities. 30 specialists, among product and interior designers, electronic, materials and mechanical engineers, primary educators, therapist, and caregivers, were involved in a co-design process to define the educational and therapeutic objectives of phygital activities, according to the Italian primary school education system
POLY-PAPER AN INNOVATIVE COMPOSITE MATERIAL FOR PACKAGING, RECYCLABLE WITH PAPER AND CARDBOARD
No full textDesigning new sustainable materials
No full textNowadays, materials development is led by circular economy criteria, market needs, and legislative issues. Product design has been in some way flanked by the material’s design. This allowed product designers to widen the mind for the application or the development of sustainable materials to be introduce in their creative environments. This work shows different research paths for the development of sustainable materials found in emerging industrial, handicraft and academic fields. Three different case studies, based on material-design approaches adopted within Design Master Degree thesis activities carried out in the laboratories of Chemistry, Materials and Chemical Engineering Department “Giulio Natta” of Politecnico di Milano are reported and clustered, too
Assessing the status of axillary sentinel lymph nodes of breast carcinoma patients by real-time quantitative RT-PCR assay for mammaglobin 1 mRNA
No full textThe aim of the study was to assess the accuracy of a real-time quantitative RT-PCR (qRT-PCR) assay for mammaglobin 1 mRNA in the detection of metastatic breast cancer in axillary sentinel lymph nodes (SLN), comparing the results with those of qualitative RT-PCR assays and of an extensive histopathological examination. A retrospective series of 81 SLN from 72 patients and a validation series of 61 SLN from 61 patients were evaluated. In the retrospective series, the qRT-PCR assay was positive for 23 (28.4%) of the 81 SLN. The overall concordance with histopathology was 93.8%, with a sensitivity of 90.9%, a specificity of 94.9%, a positive predictive value (PPV) of 87% and a negative predictive value (NPV) of 96.6%. In the same series, qualitative RT-PCR showed an overall concordance with histopathology of 86.4%, a sensitivity of 72.7%, a specificity of 91.5%, a PPV of 76.2% and a NPV of 90%. In the validation series, including 23 patients with pure in situ carcinoma, the real-time qRT-PCR assay showed an overall concordance with the histopathologic findings of 93.4%, with a sensitivity of 75.0%, a specificity of 94.7%, a PPV of 50.0% and a NPV of 98.2%. We conclude that real-time qRT-PCR assays for mammaglobin 1 are more sensitive and specific that qualitative RT-PCR assays for the detection of metastatic breast carcinoma in axillary SLN, but it should not be regarded as a possible substitute for an extensive histopathological scrutiny of the SLN in the clinical practice
Immunoreattività per il PTHrP (Parathyroid Hormon related Peptide) nei tumori polmonari
No full textSP4, a novel anti-cyclin D1 rabbit monoclonal antibody, is a high-sensitive probe for identifying mantle cell lymphomas bearing the t(11;14)(q13;q32) translocation
No full textImmunohistochemistry is the most widely used approach in the diagnosis of mantle cell lymphoma (MCL). However, its reliability may be hampered by several technical reasons, necessitating the use of alternative techniques such as the identification of the t(11;14)(q13;q32) translocation to characterize such lesions. The authors compared two monoclonal antibodies (DCS-6 and SP4) for assessing cyclin D1 immunoreactivity in a series of 22 MCLs. Their results documented that SP4, a novel rabbit monoclonal antibody, is more effective than the mouse monoclonal antibody DCS-6, one of the most commonly used reagents in daily practice. Although DCS-6 and SP4 were capable of identifying cyclin D1 immunoreactivity in 95.4% and 100% of the cases analyzed, respectively, the prevalence of cyclin D1 immunoreactive neoplastic cells was significantly (P < 0.0001) higher with SP4 (86.6 ± 13.1%) than with DCS-6 (39.8 ± 32%). Moreover, the staining intensity was faint in 16 (76.2%) cases and moderate to strong in 5 (23.8%) cases immunostained with DCS- 6, while all the cases showed a moderate to strong immunoreactivity with SP4 (P < 0.0001). According to an arbitrary score based on the percentage of immunoreactive neoplastic cells and staining intensity, only 10 (45.4%) cases were considered high cyclin D1 expressors after staining with DCS-6, whereas all the cases were high expressors with SP4 (P < 0.0001). These data provide evidence that the SP4 monoclonal antibody may be a fast, easy-to-interpret, and reliable surrogate for the detection of the (11;14) translocation by molecular techniques. Copyrigh
Meningioma polmonare: studio morfologico, immunoistochimico e ultrastrutturale di un caso
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