95 research outputs found
Use of virtual screening for discovering antiretroviral compounds interacting with the HIV-1 nucleocapsid protein
No full textThe HIV-1 nucleocapsid protein (NC) is considered as an emerging drug target for the therapy of AIDS. Several studies have highlighted the crucial role of NC within the viral replication cycle. However, although NC inhibition has provided in vitro and in vivo antiretroviral activity, drug-candidates which interfere with NC functions are still missing in the therapeutic arsenal against HIV. Based on previous studies, where the dynamic behavior of NC and its ligand binding properties have been investigated by means of computational methods, here we used a virtual screening protocol for discovering novel antiretroviral compounds which interact with NC. The antiretroviral activity of virtual hits was tested in vitro, whereas biophysical studies elucidated the direct interaction of most active compounds with NC(11-55), a peptide corresponding to the zinc finger domain of NC. Two novel antiretroviral small molecules capable of interacting with NC are presented here
Chirurgie ambulatoire : le contrôle de la douleur postopératoire n’est pas si simple que cela !
No full textÉtiquetage des ampoules d’injectables et erreurs médicamenteuses en anesthésie : le problème est-il résolu ?
No full textThe bookseller and the basketball player: tales from the French Polonia
No full textAuthor has checked copyrightAD 09/01/201
SOUTENANCE HDR DE M. PIERRE DELEAGE
No full textED 395 - SOUTENANCE HDR DE M. PIERRE DELEAGE HDR Lettres et sciences humaines - Section CNU: 20 - Anthropologie, ethnologie, préhistoire le 25 juin 2018 à 14h00 Lieu(x) Bâtiment B (Pierre Grappin) Salle René REMOND (B015) Sous la direction de M. Philippe ERIKSON, Professeur des universités. Membres du jury : M. Vincent DEBAENE, Professeur d'Enseignement Supérieur, Université de Genève, rapporteur du jury. M. Diego VILLAR, Professeur d'Enseignement Supérieur, CONICET - Buenos Aires - Arge..
R097 La variabilite de l'installation du bloc neuromusculaire est independante de la classe pharmacologique du curare
No full text- …
