26 research outputs found
L’umidità di risalita capillare negli edifici in pietra leccese: fenomeni di degrado fisico-chimico indotti sulle murature e casi applicativi del sistema elettrofisico a neutralizzazione di carica in edifici storici a Lecce
No full textL’interesse per l'idonea conservazione del patrimonio architettonico e per la sua giusta valorizzazione rende crescente l'esigenza di una valutazione attenta delle condizioni microclimatiche interne agli edifici storici, al fine di definire interventi mirati a contenere le pericolose conseguenze dell’attivazione di processi fisici di degrado.
La pietra leccese, ampiamente diffusa nel patrimonio monumentale ed edilizio del Salento, è tra i materiali porosi più facilmente degradabili. In particolare, la pietra ha proprietà e composizione chimico-fisica tali da favorire la risalita capillare di acqua.
Con l’obiettivo di verificare l’efficacia dell’innovativa apparecchiatura “a neutralizzazio-ne di carica” Domodry nel fermare l’umidità di risalita nella pietra e, quindi, favorirne l’asciugamento, sono state avviate prove in laboratorio e sono state effettuate analisi in sito - tuttora in corso - presso tre edifici salentini di elevato valore storico-artistico: la chiesa Cattedrale di Lecce, La Chiesa di San Matteo e l’edificio universitario Buon Pastore, caratterizzati da un degrado documentato dal fenomeno dell’umidita di risalita capillare.
I rilevamenti eseguiti in sito durante il primo anno dall’attivazione dell’impianto di deumidificazione muraria indicano risultati positivi in termini di riduzione dell’iniziale, anomalo contenuto d’acqua della muratura, risultati che comunque saranno compiutamente va-lutati a ciclo sperimentale concluso
An innovative technique for strengthening of masonry edge vaults: experiments and modeling
Get PDFMasonry edge vaults are typical of southern Italy and in particular of Salento. They are constituted by four barrel webs, whose vertex points do not meet at the crown of the vault as in the cross vault but are moved backwards, leaving in the middle an empty space covered with a double-curvature shell portion. This central shell has the shape of a four-point star, for which reason the structure is also commonly termed “star vault”. This paper summarizes the main results of an experimental investigation on masonry edge vaults strengthened with fiber-reinforced polymer (FRP) composites and subjected to uniform loading with measurement of the lateral thrust. Test results and theoretical predictions are presented and discussed
Pregnancy and lactation. Risk or protective factors for breast cancer?
No full textPregnancy and lactation represent the most effective protective elements against breast cancer; counter-intuitively breast cancer incidence shows a small but noticeable increase up to 5 years after delivery. The cumulative effect is however favourable and women show a reduction in breast cancer risk which is proportional to the total duration of lactation and to the number of full-term pregnancies
Il restauro delle murature e le nuove tecniche di indagine: edifici storici del Salento
No full textLa termografia applicata al risanamento di edifici storici consente di identificare, con una metodologia non distruttiva, i possibili difetti presenti nelle trame murarie ed opere d’arte, consentendo ai restauratori di intervenire sulle stesse, in modo puntuale, nelle attività di consolidamento e di recupero.
L'indagine termografica sulla trama muraria di un edificio consente, in molti casi, di risalire alla tecnica edilizia utilizzata e, in virtù dalla diversa inerzia termica dei materiali utilizzati, spesso consente di individuare discontinuità nel materiale o nella struttura o la presenza di vani nascosti o vecchie tamponature.
In presenza di affreschi, l'indagine contribuisce ad accertare lo stato di conservazione degli stessi, identificando eventuali difetti strutturali quali, ad esempio, le fessurazioni delle volte, la presenza di umidità di risalita o infiltrazioni. Inoltre, indagini di laboratorio più dettagliate, basate sulle minime differenze di emissività dei materiali e dei pigmenti nei successivi interventi di restauro, talvolta consentono di individuare le superfici originali degli affreschi o dipinti dalle superfici oggetto di interventi di restauro.
Il presente lavoro descrive l'indagine sullo stato di degrado della Chiesa dell’Incoronata in Nardò (Le), condotta con l'ausilio della tecnica termografica. La chiesa è datata 1599, si ritiene sia stata realizzata dal più famoso architetto del periodo barocco neritino, Giuseppe Tarantino. La chiesa ha una pianta a croce latina, ad una unica navata con presbiterio e transetto. Su entrambi i lati sono posizionate tre cappelle con altari lapidei lavorati. Le murature perimetrali sono formate da conci di tufo, materiale da costruzione molto diffuso a Nardò e nei paesi limitrofi, ed hanno uno spessore notevole, in media di 90 cm. È probabile che esse abbiano una struttura interna a sacco
Lactation during and after breast cancer
No full textBreastfeeding is an important aspect of mother-newborn relationship and is of great benefit for the baby. Unfortunately, many drugs taken by the mother may pass into her milk and exert an effect on the newborn. Very limited data is available and a cautionary approach is warranted especially when the woman receives anticancer treatment including chemotherapy, hormonal treatment and the recently introduced target agents as well as monoclonal antibodies. In all these conditions breastfeeding should be put on hold. More and more often physicians are faced with women that are pregnant years after the diagnosis of cancer: this has long been considered dangerous for the mother, but data show that prognosis is definitely not worse. If the woman is no longer being actively treated, breastfeeding is advisable every time it is possible, even if patients that received breast radiation may be unable to produce a sufficient amount of milk on that side
A new robot-assisted Billroth-I reconstruction. Details of the technique and early results
No full textBACKGROUND:
Laparoscopic surgery for gastric tumor is considered a demanding procedure because of lymph node dissection and reconstruction. Billroth-I (B-I) reconstruction after laparoscopic distal gastrectomy is commonly performed extracorporeally because of the complexity of an intracorporeal procedure. Robotic surgery overcomes some limitations of laparoscopy, allowing to reproduce the basic maneuvers of open surgery. We describe a new technique to perform robotic B-I anastomosis.
METHODS:
Between January 2012 and February 2015, 5 patients underwent distal gastrectomy with intracorporeal B-I-stapled anastomosis. Patient demographics, tumor characteristics, histopathologic features, and perioperative data were analyzed.
RESULTS:
Median operative time was 170 minutes (145 to 180 min). There were no conversions. Contrast swallow was routinely performed on the third postoperative day. Median postoperative hospitalization was 7 days (range: 6 to 8). No major complications or mortality were observed.
CONCLUSIONS:
Robotic distal gastrectomy with intracorporeal B-I anastomosis is a safe and promising technique in selected cases of gastric tumors
The only thing I know is that I know nothing": 5-fluorouracil in human milk
No full text[No abstract available
Arsenical C-Glucoside derivatives with promising antitumor activity
No full textC-Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized by avoiding protection-deprotection steps. While compound 1, bearing an AsV atom, did not show any significant biological activity, compound 2, in which the glucose moiety is linked to the arsenic atom as dithioarsenical (AsIII), showed promising antiproliferative activity on a cell line of neuroblastoma (SK-N-BE). C-Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized. The C-glucoside conjugated to the phenyldithioarsolan group, showed promising antiproliferative activity on human neuroblastoma cells (SK-N-BE)
First-in-human pharmacokinetics of tamoxifen and its metabolites in the milk of a lactating mother. A case study
Get PDFBackground Breast cancer represents the most frequent neoplasm diagnosed in women of childbearing age. When the tumour is oestrogen receptor-positive, tamoxifen is among the recommended endocrine treatments. Lactating women are advised not to breastfeed while receiving tamoxifen. However, information about tamoxifen transfer into breast milk is lacking. Methods We measured the concentration of tamoxifen and its metabolites by liquid chromatography-tandem mass spectrometry in the milk of a nursing mother that was treated for pregnancy-associated breast cancer diagnosed a few months after delivery. She was advised not to breastfeed her child and she collected milk samples for 23 days while the baby was fed with formula. Results Tamoxifen concentrations in milk increased reaching a maximum of 214 nM. The two active metabolitesZ-4-hydroxy-tamoxifen and Z-endoxifen, could not be quantified in milk the first days after tamoxifen intake, but increased over time and reached clinically significant levels after day 18. Conclusion This study demonstrates for the first time in human that tamoxifen and its metabolites transfer into milk. Since tamoxifen has a complete oral bioavailability, a long half-life (>7 days) and may interfere with the normal development of the infant, mothers should not breastfeed during tamoxifen treatment
Robotic surgery for colorectal liver metastases resection: a systematic review
Get PDFBackground: The role of robotic surgery for colorectal cancer liver metastases (CRCLMs) has never been investigated in large series. Methods: A systematic literature review was carried out on PubMed and Cochrane libraries. Results: We selected nine studies between 2008 and 2021. Two hundred sixty-two patients were included. One hundred thirty-one patients underwent simultaneous resections. The mean blood loss was 309.4 ml (range, 200-450 ml), the mean operative time was 250.5 min (range, 198.5-449.0 min). The mean length of hospital stay was 7.98 days (range, 4.5 to 12 days). The overall postoperative mortality was 0.4%. The overall morbidity rate was 37.0%, Clavien-Dindo grade III-IV complications were 8.4%. The mean 3-year overall survival was 55.25% (range, 44.4-66.1%), the mean 3-year disease free survival was 37% (range, 33.3-41.9%). Conclusion: We can conclude that robotic-assisted surgery might be considered as a technical upgrade option for minimally invasive approach to CRCLM resections even for simultaneous operations and challenging cases
