645 research outputs found
Bertoldo, Bertoldino e Cacasenno, poema giocoso.
No full textPoem in 20 cantos each by a different author, G.P. Riva, P.B. Balbi and others, which is a metrical version of the prose romances "Le sottilissime astutie di Bertoldo" and "Le piacevoli et ridicolose simplicità di Bertoldino" by G.C. Croce and the "Novella di Cacasseno" by A. Banchieri under the pseudonym of Camillo Scaligeri della Fratta.Mode of access: Internet
Targeting bone metastases starting from the preneoplastic niche: home sweet home
No full textThe metastatic process is a multistep coordinated event with a high degree of efficiency. Specific subpopulations of cancer stem cells, with tumor-initiating and migratory capacity, can selectively migrate towards sites that are able to promote survival and/or proliferation of metastatic tumor cells through a microenvironment modification. Cross-talk between the bone microenvironment and cancer cells can facilitate bone tropism of cancer cells. Fully understanding this complexity represents a major challenge in anti-cancer research and a mandatory step towards the development of new drugs potentially able not only to reduce the consequences of bone lesions but also to target the metastatic process in visceral sites
medical oncology:zoledronic axcid prevents bone loss in early-stage breast cancer
No full textZoledronic acid is effective in the prevention of bone loss in premenopausal women with breast cancer being treated with endocrine therapy. The benefit of zoledronic acid probably extends for some years after cessation of therapy
Swelling of responsive-microgels: experiments versus models
No full textInterpenetrated Polymer Network (IPN) microgels of PNIPAM and PAAc have been investigated and the experimental data have been compared with theoretical models from the Flory–Rehner theory. We confirm that the swelling behavior of PNIPAM microgels is well described by this theory by considering the second order approximation for the volume fraction φ dependence of the Flory parameter χ(φ). Indeed the Volume-Phase Transition (VPT) of the PNIPAM-PAAc IPN microgel at neutral conditions and in D2O solvents can be well described only considering a third-order approximation. Interestingly we empirically find that sharper is the transition higher is the order of the χ(φ) relation which has to be considered. Moreover the VPT can be experimentally controlled by tuning the polymer/solvent interactions through pH and solvent allowing to directly modify the delicate balance between energetic and entropic contributions and to explore the swelling behavior in a wide range of environmental conditions. In particular we find that the most advantageous condition for swelling is in water at acidic pH
Stimuli responsive IPN microgels of PNIPAM and PAAc: preparation, thermal and pH response
No full text
The role of the microenvironment,vitamin D and calcium
No full textl'artoclop descrive le influenze dirette ed indiretta del defrict di vitamina D nel promuovere un micromabiente favorevole ll'homing delle cellule neoplastiche nel midollo promuovendo la nicchia premetatstic
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