747 research outputs found
Countermovements in Europe? A Polanyian Perspective
No full textCountermovements in Europe? A Polanyian perspective Martin Seeliger/ Bernd Sommer Trade union politics as a countermovement? A Polaniyan perspective Martin Seeliger Trade unions and the Polanyian countermovement: a Southern perspective Edward Webster The fictitious commodification of money and the Euro experiment Maja Savevska Accumulation via QE: comment on Maja Savevska’s "The fictitious commodification of money and the Euro experiment" Jonah Stuart Brundage The EU emissions trading scheme: protection via commodification? Christopher M. Rea Polanyi, markets and environmental protection Arild Vatn Rise of right-wing populism in the Europe of today – outlines of a sociotheoretical exploration Hans-Jürgen Bieling A great variety of transformations – and populisms Floris Biskamp The Economy for the Common Good: a European countermovement against the destructive impacts of laissez-faire capitalism? Klara Stumpf/ Bernd Sommer Karl Polanyi and discussions on a renewed socialism Michael Brie Of (anti-)capitalism, countermovements, and socialdemocratic bedtime stories. A review of recent literature on Polanyi Moritz Müller The reality of exclusive solidarity A response to Wolfgang Streeck’s "Between Charity and Justice" Silke van Dyk/ Stefanie Graefe Between clarity and disorientation: remarks on the unease of Wolfgang Streeck with the 21st century migration Ludger Pries Keep it straight and simple, also with respect to migration: a comment on Streeck’s "Between Charity and Justice" Andreas Nölke A search for alternatives: Hauke Brunkhorst, Donatella della Porta and Fritz W. Scharpf on the state of the European Integration Monika Eigmüller/ Martin Seelige
Akrofaziale Dysostose Typ Nager
No full textAcrofacial dysostosis type Nager in neonates is associated with high morbidity and mortality as a result of respiratory problems. Tracheotomy should be considered in order to stabilize the respiratory situation promptly. Primary mandibular distraction osteogenesis is not able to guarantee sufficient stabilization of the respiratory situation given the small bone structures; this approach should be reserved for older and larger patients
Fiktionalität als Grenzbearbeitung symbolischer Repräsentationen. Ein intersektionaler Versuch am Beispiel Star Trek
No full textHoffarth B. Fiktionalität als Grenzbearbeitung symbolischer Repräsentationen. Ein intersektionaler Versuch am Beispiel Star Trek. In: Fretschner R, Knüttel K, Seeliger M, eds. Intersektionalität und Kulturindustrie. Bielefeld: transcript; 2011
Atomic contacts in protein structures. A detailed analysis of atomic radii, packing, and overlaps.
No full textNew soft-core potential function for molecular dynamics based alchemical free energy calculations.
No full textThe fields of rational drug design and protein engineering benefit from accurate free energy calculations based on molecular dynamics simulations. A thermodynamic integration scheme is often used to calculate changes in the free energy of a system by integrating the change of the system’s Hamiltonian with respect to a coupling parameter. These methods exploit nonphysical pathways over thermodynamic cycles involving particle introduction and annihilation. Such alchemical transitions require the modification of the classical nonbonded potential energy terms by applying soft-core potential functions to avoid singularity points. In this work, we propose a novel formulation for a soft-core potential to be applied in nonequilibrium free energy calculations that alleviates singularities, numerical instabilities, and additional minima in the potential energy for all combinations of nonbonded interactions at all intermediate alchemical states. The method was validated by application to (a) the free energy calculations of a closed thermodynamic cycle, (b) the mutation influence on protein thermostability, (c) calculations of small ligand solvation free energies, and (d) the estimation of binding free energies of trypsin inhibitors. The results show that the novel soft-core function provides a robust and accurate general purpose solution to alchemical free energy calculations
Protein thermostability calculations using alchemical free energy simulations.
No full textAbstractThermal stability of proteins is crucial for both biotechnological and therapeutic applications. Rational protein engineering therefore frequently aims at increasing thermal stability by introducing stabilizing mutations. The accurate prediction of the thermodynamic consequences caused by mutations, however, is highly challenging as thermal stability changes are caused by alterations in the free energy of folding. Growing computational power, however, increasingly allows us to use alchemical free energy simulations, such as free energy perturbation or thermodynamic integration, to calculate free energy differences with relatively high accuracy. In this article, we present an automated protocol for setting up alchemical free energy calculations for mutations of naturally occurring amino acids (except for proline) that allows an unprecedented, automated screening of large mutant libraries. To validate the developed protocol, we calculated thermodynamic stability differences for 109 mutations in the microbial Ribonuclease Barnase. The obtained quantitative agreement with experimental data illustrates the potential of the approach in protein engineering and design
Das Mensch-Tier-Verhältnis: Eine sozialwissenschaftliche Einführung
No full textEinleitung Frank Thieme „Aber die sind doch dazu da!“ Skizze einer Soziologie der Mensch-Tier-Verhältnisse Martin Seeliger Die soziale Konstruktion des Anderen – Zur soziologischen Frage nach dem Tier Birgit Mütherich Mit Tieren denken: Die Soziologie der nicht-menschlichen Tiere in der Gesellschaft Arnold Arluke, Clinton Sanders und Patricia Morris Tierkapital, Spezieszugehörigkeit und soziale Ungleichheit Melanie Bujok Differenz, Indifferenz, Gewalt: Die Kategorie „Tier“ als Prototyp sozialer Ausschließung Michael Fischer Für eine radikale Ethik – Die Tierrechtsbewegung in der ersten Hälfte des 20. Jahrhunderts Renate Brucker Über die symbolische Reproduktion einer tiervernichtenden Kultur Christina Möller Tiere im Bilderbuch: Mediale Sozialisierung und das Mensch-Tier-Verhältnis Jutta Buchner-Fuhs Indigene Kulturen, tierliche Spezies, tierliche Individuen: Fragen zu Ressourcismus und Anthropozentrismus Barbara Nosk
Conformational Transitions Upon Ligand Binding: Holo Structure Prediction from Apo Conformations
No full textBiological function of proteins is frequently associated with the formation of complexes with small-molecule ligands. Experimental structure determination of such complexes at atomic resolution, however, can be time-consuming and costly. Computational methods for structure prediction of protein/ligand complexes, particularly docking, are as yet restricted by their limited consideration of receptor flexibility, rendering them not applicable for predicting protein/ligand complexes if large conformational changes of the receptor upon ligand binding are involved. Accurate receptor models in the ligand-bound state (holo structures), however, are a prerequisite for successful structure-based drug design. Hence, if only an unbound (apo) structure is available distinct from the ligand-bound conformation, structure-based drug design is severely limited. We present a method to predict the structure of protein/ligand complexes based solely on the apo structure, the ligand and the radius of gyration of the holo structure. The method is applied to ten cases in which proteins undergo structural rearrangements of up to 7.1 A backbone RMSD upon ligand binding. In all cases, receptor models within 1.6 A backbone RMSD to the target were predicted and close-to-native ligand binding poses were obtained for 8 of 10 cases in the top-ranked complex models. A protocol is presented that is expected to enable structure modeling of protein/ligand complexes and structure-based drug design for cases where crystal structures of ligand-bound conformations are not available
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