1,417 research outputs found
On pressure dependence of the relative compression (V/V0) at room temperature for the solids : copper and lead as prototypes
No full textA correction term has been introduced in the usual Tait’s equation of state (EOS) and then used to predict the pressure dependence of the thermal compression for the solids : copper (Cu) and lead (Pb). The predictive capabilities of the complete EOS are discussed. The results obtained from the modified Usual Tait’s equation of state are found closer to the available experimental data as compared to those values achieved without taking into account the correction factor in the original Tait’s equation of state.Author Affiliation: Deepika Kandpal, K Y Singh and B R K Gupta
1.Department of Physics, G. B. Pant University of Agriculture and Technology,
Pantnagar-263145, India
E-mail : [email protected] of Physics, G. B. Pant University of Agriculture and Technology,
Pantnagar-263145, Indi
sj-docx-1-aor-10.1177_00034894211072996 – Supplemental material for The Role of Educational Podcast Use Among Otolaryngology Residents
No full textSupplemental material, sj-docx-1-aor-10.1177_00034894211072996 for The Role of Educational Podcast Use Among Otolaryngology Residents by Erik B. Vanstrum, Ido Badash, Franklin M. Wu, Harrison J. Ma, Deepika N. Sarode, Tamara N. Chambers and Michael M. Johns in Annals of Otology, Rhinology & Laryngology</p
Do Labor Intensive Industries Generate Employment? Evidence from firm level survey in India
No full textThis study attempts to address the issue of declining labour intensity in Indias organized manufacturing in order to understand the constraints on employment generation in the labour intensive sectors. Using primary survey data covering 252 labour intensive manufacturing-exporting firms across five sectorsapparel, leather, gems and jewellery, sports goods, and bicycles for 2005-06 an attempt is made to find out the factors which constrain employment generation in labour intensive firms. The study shows several constraints in the path of employment generation in labour intensive sectorsnon-availability of trained skilled workers, infrastructure bottlenecks, low levels of investment, labour rules and regulations, and a noncompetitive export orientation. The study suggests a set of policy initiatives to improve the employment potential of these sectors.Indian Organized Manufacturing, Labor Intensity, Employment Growth, Skilled workforce, Wage Structure, Export status, Machinery Usage, Labor laws, South Asia
sj-docx-1-aor-10.1177_00034894221139107 – Supplemental material for Virtual Versus In-Person Head and Neck Physical Examination Training in Medical Students: A Pilot Assessment
No full textSupplemental material, sj-docx-1-aor-10.1177_00034894221139107 for Virtual Versus In-Person Head and Neck Physical Examination Training in Medical Students: A Pilot Assessment by Khush M. Kharidia, Matthew E. Lin, Jonathan D. West, Deepika N. Sarode, Harrison J. Ma, Erik B. Vanstrum, Franklin M. Wu and Michael M. Johns in Annals of Otology, Rhinology & Laryngology</p
ASSESSMENT OF THE EFFECTS OF WHOLE BODY AND REGIONAL SOFT TISSUE COMPOSITION ON BONE STRENGTH AND DEVELOPMENT IN FEMALES.
No full textRights Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author
Protein synthesis inhibition by didemnin B: Mechanistic insights.
No full textDidemnin B is an inhibitor of eukaryotic protein synthesis and displays potent anti-viral, antineoplastic and immunosuppressive properties. We have established a structure-activity relationship for the inhibition of protein synthesis by didemnin B in vitro. The SAR data obtained indicate that the native conformation of didemnin B is critically important for activity. The relative order of potency of didemnin analogs for protein synthesis inhibition in vitro correlates well with that in intact cells; thus, the inferences drawn regarding SAR for translation inhibition in vitro should also hold true in cells. Previous mechanistic studies had shown that didenmin B specifically inhibits translation elongation by preventing the eEF-2-mediated translocation step and that this inhibitory activity is mediated by eEF-1alpha in vitro . We have examined this mechanism in greater detail. We have shown that didemnin B binds to the ribosome complex, with modest affinity (Kd ∼ 4 muM), in an eEF-1alpha dependent manner. In the presence of didemnin B, eEF-2 is blocked from binding to the ribosome complex and therefore translocation is inhibited. We propose that the interaction between didemnin B and eEF-1alpha on the ribosome locks the ribosome complex in a conformation unfavorable for eEF-2 binding; alternatively, on associating with ribosome-bound eEF-1alpha, didemnin B occupies eEF-2's binding site, thus physically occluding eEF-2 from accessing the ribosome. Currently, there is no way to distinguish between these modes of inhibition. We have shown that inhibition of cellular protein biosynthesis by didemnin B is sufficient to inhibit cell proliferation, but not sufficient to trigger apoptosis. Thus, at low concentrations, didemnin B is a cytostatic agent, but not cytotoxic.PhDBiochemistryPure SciencesUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/131837/2/9938389.pd
Low frequency dielectric dispersion study of PVC-PPy blends in dilute solution of different solvents
No full textStudy of temperature dependent electrical properties of Se80-xTe20Bix (x = 0, 3, 6) glasses
No full textRepeat dose of gonadotropin-releasing hormone agonist trigger in polycystic ovarian syndrome undergoing In Vitro fertilization cycles provides a better cycle outcome - a proof-of-concept study
No full textObjective: Is a single dose of gonadotropin-releasing hormone agonist (GnRHa) trigger to induce final oocyte maturation in polycystic ovarian syndrome (PCOS) undergoing in vitro fertilization (IVF) cycles with GnRH antagonist protocol sufficient to provide optimal oocyte maturity? Design: This is a prospective, randomized, double-blind, proof-of-concept study. Setting: This study was carried out at a tertiary care center. Material and Methods: A total of 125 patients diagnosed with PCOS defined as per the ESHRE/ASRM Rotterdam criteria (2003) undergoing IVF in antagonist protocol were randomized into two groups. Group A: single dose of GnRHa 0.2 mg, 35 h prior to oocyte retrieval, and Group B: 0.2 mg GnRHa 35 h prior to oocyte retrieval + repeat dose of 0.1 mg 12 h following the 1st dose. 12 h post-trigger, luteinizing hormone (LH), progesterone (P4), and follicle-stimulating hormone (FSH) values were estimated. Statistical Analysis: Continuous variables were expressed as mean ± standard deviation and categorical variables as proportions where applicable. Independent sample t-test was used for continuous variables which were normally distributed and Mann–Whitney U-test for data not normally distributed. Chi-square test or Fisher's exact test was used for categorical variables where appropriate. Odds ratio (OR) with 95% confidence intervals (CIs) was calculated. In addition, receiver operating characteristic curve was used to evaluate the post-trigger LH, P4, and FSH values at 12 h as predictors of oocyte maturity. Main Outcome Measures: Primary outcome: maturity rate of the oocytes. Secondary outcomes: oocyte yield, fertilization rate, availability of good quality embryos on day 3, blastocyst conversion, OHSS rates, post-trigger serum LH (IU/L), FSH (IU/L), and P4 (ng/mL) levels implantation rate and clinical pregnancy rate. Results: A higher number of mature (metaphase II) oocytes were obtained in Group B compared to Group A (OR of 0.47; CI: 0.38–0.57; P < 0.01). Significantly a higher number of blastocysts were obtained in Group B than Group A (4.00 vs. 3.04; P = 0.023). The odds of clinical pregnancy per patient were higher in Group B (OR = 0.56; CI [0.27–1.24]), with a trend towards better clinical pregnancy in Group B than in Group A. Conclusions: A repeat dose of GnRHa trigger 12 h following the first dose probably by maintaining a sustained level of gonadotropins yielded a better maturity of oocytes, higher number of blastocysts, and a trend towards higher clinical pregnancy than a single dose in PCOS patients undergoing IVF in antagonist cycles
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