98 research outputs found
Author reply
No full textHealth data linkage in Australia remains challenging1 as reflected in our recent experience of multi‐jurisdictional data linkage. We welcome the Population Health Research Network (PHRN) collaborative's initiatives in establishing a streamlined and unified application process in multi‐jurisdictional data linkage projects, and we fully support their vision. We acknowledge the concerns raised by Flack and Smith2 and take this opportunity to elaborate.Full Tex
The social exclusion in the novel Fahim Bey ve Biz: Conflicts between ındividual and society
No full textAbdülhak Şinasi Hisar yirminci yüzyıl Türk edebiyatının yazarlarındandır. Edebiyatın farklı alanlarında eserler vermesine rağmen, esasen romanlarıyla tanınır. Yazarın önemli yapıtlarından biri de Fahim Bey ve Biz romanıdır. Eserin başat karakteri çevresiyle çelişkiler yaşamaktadır. Bu çatışmalar onun kişiliğine de yansımıştır. Bu bağlamda kahramanın dualist kişiliğe sahip olduğunu da görüyoruz. Fakirken kendisini zengin gibi görmek, hiçbir işi olmazken, kendisini iş adamı gibi göstermek dualist kişiliğin bir göstergesi olarak karşımıza çıkıyor. Bunun önemli nedeni toplumun Fahim Bey`i dışlaması, ona hoşgörülü davranmamasıdır. Fahim Bey tüm tuhaflıklarıyla sosyal dışlanmaya maruz kalıyor. Kendi kabuğuna çekilerek tamamen yalnızlaşıyor. Belirtmemiz gerekir ki sosyal dışlanma birey ve toplum arasındaki çelişkilerden meydana gelen bir olgu olarak nitelendirilmektedir. Makalede, Abdülhak Şinasi Hisar`ın Fahim Bey ve Biz romanı sosyal dışlanma kavramı çerçevesinde incelenmiştir. Toplum ve birey arasındaki sosyal dışlanmaya yol açan çelişkiler, analiz edilerek ortaya çıkarılmaya çalışılmıştır. Çalışmada, betimsel analiz yöntemi kullanılmıştır.Abdülhak Şinasi Hisar is one of the writers of twentieth century Turkish Literature. Although he has written works in different fields of literature, he is mainly known for his novels. One of the important works of the author is Fahim Bey ve Biz (Fahim Bey and We). The principal character of the novel is in contradiction with his environment. These conflicts are reflected in his personality. In this context, we also see that the hero has a dualist personality. Seeing himself as rich although he is poor, and pretending to be a businessman even though he has no job are indications of his dualist personality. The important reason for this is that the society excludes Fahim Bey, and does not treat it tolerantly. Fahim Bey is exposed to social exclusion with all his oddities. Withdrawing to his own shell, he is completely alone. Social exclusion is defined as a phenomenon that consists of contradictions between the individual and the society. In this article, Fahim Bey ve Biz novel by Abdülhak Şinasi Hisar is examined within the contect af the concept of social exclusion. The contradictions leading to social exclusion between the society and the individual were tried to be revealed by analyzing. Descriptive analysis method was used in the study
Macro Consumption Function in an Islamic Framework by Fahim Khan: Comments
No full textThis is a critique of an article of M. Fahim Khan pulished in an earlier issue of the same journal It argues that in other economic systems including capitalism too play an important role to mitigate the hardships of the poor but unlike the Islamic system they do not show their impact on income determination. Transfer of income to the poor via zakah will reduce the saving potential of the economy. To what extent this will be neutralized by the rich abstaining from frivolous spending due to the fear of God is uncertain. Hence the macro model of the author to demonstrate the superiority of the Islamic system is not convincing
Macro Consumption Function in an Islamic Framework by Fahim Khan: Comments
No full textThis is a critique of an article of M. Fahim Khan pulished in an earlier issue of the same journal It argues that in other economic systems including capitalism too play an important role to mitigate the hardships of the poor but unlike the Islamic system they do not show their impact on income determination. Transfer of income to the poor via zakah will reduce the saving potential of the economy. To what extent this will be neutralized by the rich abstaining from frivolous spending due to the fear of God is uncertain. Hence the macro model of the author to demonstrate the superiority of the Islamic system is not convincing.Islam and consumption; zakah; israf
On a generalization of power algorithms over max-plus algebra
No full textIn this paper we discuss a generalization of power algorithms over max-plus algebra. We are interested in finding such a generalization starting from various existing power algorithms. The resulting algorithm can be used to determine the so-called generalized eigenmode of any square regular matrix over max-plus algebra. In particular, the algorithm can be applied in the case of regular reducible matrices in which the existing power algorithms can not be used to compute eigenvalues and corresponding eigenvectors.Accepted Author ManuscriptMathematical Physic
Scalable platforms for computation and memory in living cells
No full textThesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2018.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 245-265).Living cells are biological computers - constantly sensing, processing and responding to biological cues they receive over time and space. Devised by evolution, these biological machines are capable of performing many computing and memory operations, some of which are analogous to and some are distinct from man-made computers. The ability to rationally design and dynamically control genetic programs in living cells in a robust and scalable fashion offers unprecedented capacities to investigate and engineer biological systems and holds a great promise for many biotechnological and biomedical applications. In this thesis, I describe foundational platforms for computation and memory in living cells and demonstrate strategies for investigating biology and engineering robust, scalable, and sophisticated cellular programs. These include platforms for genomically-encoded analog memory (SCRIBE - Chapter 2), efficient and generalizable DNA writers for spatiotemporal recording and genome engineering (HiSCRIBE - Chapter 3), single-nucleotide resolution digital and analog computing and memory (DOMINO - Chapter 4), concurrent, autonomous and high-capacity recording of signaling dynamics and events histories for cell lineage mapping with tunable resolution (ENGRAM - Chapter 5), continuous in vivo evolution and synthetic Lamarckian evolution (DRIVE - Chapter 6), tunable and multifunctional transcriptional factors for gene regulation in eukaryotes (crisprTF - Chapter 7), and an unbiased, high-throughput and combinatorial strategy for perturbing transcriptional networks for genetic screening (PRISM - Chapter 8). I envision the platforms and approaches described herein will enable broad applications for investigating basic biology and engineering cellular programs.by Fahim Farzadfard.Ph. D
Evolutionary study on two closed Gammarus (Crustacea, Amphipoda) species from Zagros Mountains (IRAN) using molecular methods
No full textMitochondrial Cytochrome Oxidase Subunit I DNA sequences are a good discriminative marker for phylogenetic studies in crustaceans and especially in amphipoda. In the present study, molecular and morphological data were analyzed to test whether Gammarus lobifer authority and Gammarus balutchi authority which one or two geographically separated but morphologically similar species. The analyses proved that there are two species and that uplift of the Zagros Mountains was probably the most important cause of Allopatric speciation in this region during the Miocene period.Publishe
Evolutionary study on two closed Gammarus (Crustacea, Amphipoda) species from Zagros Mountains (Iran) using molecular methods
No full textMitochondrial Cytochrome Oxidase Subunit I DNA sequences are a good discriminative marker for phylogenetic studies in crustaceans and especially in amphipoda. In the present study, molecular and morphological data were analyzed to test whether Gammarus lobifer authority and Gammarus balutchi authority which [sic] one or two geographically separated but morphologically similar species. The analyses proved that there are two species and that uplift of the Zagros Mountains was probably the most important cause of Allopatric speciation in this region during the Miocene period
RETRACTION: Optimization of conditions for the biological treatment of textile dyes using isolated soil bacteria
No full textThe article titled “Optimization of conditions for the biological treatment of textile dyes using isolated soil bacteria” ([version 1; referees: peer review discontinued]. F1000Research 2018, 7:351 https://doi.org/10.12688/f1000research.13757.1) by Shafkat Shamim Rahman and colleagues, has been retracted by F1000Research on grounds of misconduct by the first author. Following publication of the article, the editorial team at F1000Research were notified by Romana Siddique, from BRAC University, that the data presented in this paper significantly overlaps with the data in her recently published article : Siddique and Alif; ARRB, 22(5): 1-12, 2018; Article no.ARRB.38637; https://doi.org/10.9734/ARRB/2018/38637. In response to our queries to the authors, the second and last author listed on this article, Fahim Ahmed Alif and M. Mahboob Hossain, have stated that they were not aware of the submission of this article to F1000Research, and did not agree to be authors. We have evidence which confirms their statement. After further investigation by the F1000Research team, and a separate investigation by BRAC University, it has become clear that Shafkat Shamim Rahman was not involved with the research presented in this paper, and that the decision to submit and publish the article was taken independently by him, and not his listed co-authors. BRAC University has confirmed that Shafkat Shamim Rahman is not currently based at their institution.</ns4:p
Nicotine-induced escalation of ethanol intake - an effect mediated by the vagus nerve
No full textAbstract
Supervisor:
Docent
Mia
Ericson
Author:
Fahim
Sharan
Nicotine-‐induced
escalation
of
ethanol
intake-‐
an
effect
mediated
by
the
vagus
nerve?
There is a clear connection between alcohol abuse and smoking. Previous studies
show that 83% of those with alcohol abuse also smoke and that alcoholism is 10 times
more common in smokers than in non-smokers. This clinical observation also finds
support in pre-clinical animal studies where nicotine treatment has shown to increase
ethanol intake in rats. Current research shows that central nicotinic acetylcholine
receptors (nAChR) play a vital role in the dopamine releasing effects of ethanol.
However, other studies have demonstrated that blockade of peripheral ganglionic
nAChR invokes some kind of adaptations, which in turn escalates ethanol intake. We
have reason to believe that both peripheral and central nAChR are involved in ethanol
consumption. Since the vagus nerve receives input via nAChRs and is a big
contributor to the autonomic nervous system, our hypothesis is that this nerve
mediates the nicotine-induced escalation of ethanol intake. Thus this present study
focused on designing a method that allowed us to surgically ligate certain branches of
the vagus nerve in the rat thus removing the peripheral nAChR influence of ethanol
intake. If we manage to establish a successful method we will later be able to let
vagotomized rats undergo an ethanol-consumption study where we can evaluate if the
abolished influence of the vagus nerve changes nicotine-induced escalation of ethanol
intake.
A total of 16 animals across 4 trials were operated on during the course of this study.
6 animals were judged to have a successful vagotomy, resulting in a 40% success rate
for the surgical procedure. However, we faced great challenges with stabilizing the
animals in the post-operative phase due to persisting weight loss, but were finally
successful in stabilizing the weight in trial 4 with a liquid diet. All in all, we managed
to achieve a successful gastric vagotomy with a stable post-operative weight gain in
only 1 animal of the 16 operated. Conclusively, more surgical practice is needed
before achieving an optimal method. However, we believe that with practice, a higher
success rate of vagotomy can be achieved and along with a post-operative diet based
on liquid diet we will have vagotomized animals stable enough to undergo a voluntary
ethanol intake paradigm.
Key
words:
Ethanol
intake,
nicotine,
vagus
nerve,
vagotomy
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