66 research outputs found
MiRNAs-based Gene Therapy on the Horizon: Novel and Effective Therapeutic Advancement
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Prevalence of metabolically unhealthy obesity, overweight, and normal weight and the associated risk factors in a southern coastal region, Iran (the PERSIAN cohort study): a cross-sectional study
No full textAbstract Background Obesity is a substantial risk factor for cardiovascular and metabolic diseases. Epidemiologic studies have shown that some obese and overweight individuals are metabolically healthy. We aimed to determine the prevalence of metabolically unhealthy obesity (MUO), metabolically unhealthy overweight (MUOW), and metabolically unhealthy normal weight (MUNW) in a southern coastal area of Iran, Bandare-Kong Non-Communicable Diseases (BKNCD) Cohort Study. Methods This population-based study included the participants of BKNCD, as part of the Prospective Epidemiological Research Studies in IrAN (PERSIAN). Metabolic health was defined as not fulfilling the metabolic syndrome (MetS) criteria. Results Among the 3917 participants in this study with the mean age of 48.29 ± 9.39 years, including 1691 (43.2%) males, the age- and sex-standardized prevalence of MUO, MUOW, and MUNW was 13.9, 16.8, and 6.4%, respectively. Binary logistic regression analysis revealed that the adjusted odds of all metabolically unhealthy states were higher in older age groups, except for MUO whose adjusted odds were lower in the 65–70 age group compared to the 55–64 age group. Illiteracy was significantly correlated with MUOW (adjusted OR: 1.43, 95% CI 1.09–1.87, P = 0.010); however, it was not associated with MUO or MUNW. Higher body mass index (BMI) was significantly correlated with MUNW but it was not associated with MUOW or MUO. Higher waist circumference (WC) was also significantly associated with all metabolically unhealthy states. Conclusion The age- and sex-standardized prevalence of MUO, MUOW, and MUNW was 13.9, 16.8, and 6.4%, respectively in the current study. Advanced age and higher WC were significantly correlated with all metabolically unhealthy states, while illiteracy and higher BMI were only associated with MUOW and MUNW, respectively. Metabolic health rather than weight loss should be the focus and objective of public prevention programs
The imbalance in expression of angiogenic and anti-angiogenic factors as candidate predictive biomarker in preeclampsia
No full textPreeclampsia is an important pregnancy disorder with serious maternal and fetal complications which its etiology has not been completely understood yet. Early diagnosis and management of disease could reduce its potential side effects. The vascular endothelial growth factor (VEGF) family including VEGF-A is the most potent endothelial growth factor which induces angiogenesis and endothelial cell proliferation and has basic role in vasculogenesis. VEGF and its tyrosine kinase receptors (Flt1 and KDR) are major factors for fetal and placental angiogenic development. Finding mechanisms involved in expression of angiogenic factors may lead to new prognostic and therapeutic points in management of preeclampsia. Recent researches, has shown capability of some anti-angiogenic factors as potential candidate to be used as early predictors for preeclampsia. Soluble fms-like tyrosin kinase-1 (sFlt1) is a truncated splice variant of the membrane-bound VEGF receptor Flt1, that is produced by the placenta and it can bind to angiogenic growth factors and neutraliz, their effects. It is also observed that the ratio of sFlt1 to placental growth factor is valuable as prognostic marker. In this review, VEGF family member’s role in angiogenesis is evaluated as biomarkers to be used for prediction of preeclampsia
Significance of blood-related high-risk behaviors and horizontal transmission of hepatitis B Virus in Iran
No full textAssociation of methylenetetrahydrofolate reductase (MTHFR) and cystathionine β-synthase (CBS) genes promoter methylation pattern with the risk of essential hypertension
No full textAssociation of GNB3 C825T polymorphism with plasma electrolyte balance and susceptibility to hypertension
No full textConstraining Factors of Research among faculty members at Hormozgan University of Medical Sciences
No full textIntroduction: In recent decades, the major criteria for development in countries were defined mostly by research
position. The first step in organizing the research subject in societies is gaining a correct perception of abilities,
available facilities, and finding the strengths and weaknesses of research programs. This research was conducted
to determine the constraining factors of research among faculty members.
Methods: In this cross-sectional study in 2013, the population was Hormozgan Medical Science faculty
members, and samples were selected based on the Morgan table (138 individuals). A researcher-made
questionnaire after determining validity and confirming reliability was distributed among them. The data were
analyzed by SPSS using descriptive and inferential statistics, such as Pearson’s product-moment correlation.
Results: Among organizational factors, lack of data presentation to researchers from organization sections with
81.2% was the most effective factor. The lack of facilitating national and international research exchange with
80.5% and the lack of research workshops based on needs with 77.9% were the next ones. Among the personal
constraining factors, 64% of the faculty declared that having inadequate time for research due to the educational
activities was the main factor.
Conclusions: According to the faculty’s comments, research activities encounter different constraining factors. It
can be said that, by promoting a data registration system, collaborating on contract agreements and improving
national and international research exchange, empowering members' research (need-based workshops), and
decreasing the faculty’s clinical and educational activities can overcome these constraints
Tamarind Intake and Hypertension: An Alarming Association Found in the Bandar Kong Cohort Study
No full textBackground: Hypertension (HTN) is a significant global public health concern and can elevate the risk of cardiovascular and kidney diseases. Tamarind (Tamarindus indica, Fabaceae), a tropical fruit highly valued for its pulp, offers many health benefits, including a reduction in oxidative stress and inflammation. Nonetheless, emerging uncertainties surround Tamarind’s efficacy in certain health aspects. This study examined its potential negative impact on HTN within the Bandar Kong cohort. Materials and Methods: The current study included 2823 participants of the Bandar Kong cohort study, of whom 693 individuals (24.5%) had HTN, with 288 men (25.3%) and 405 women (24.0%) being affected. Binary logistic regression analysis was used to investigate the connections between variables and the likelihood of HTN in both men and women. Moreover, multivariable binary logistic regression analysis and multivariable linear regression were utilized to determine the correlation between Tamarind consumption and the risk of HTN. Results: After adjusting for covariates, the odds of HTN in males with moderate consumption of Tamarind were 0.55 higher than in males with low consumption of Tamarind. Tamarind consumption was significantly associated with the risk of HTN in both genders, with males and females who consumed moderate to high amounts having a higher risk. The findings revealed that high consumption of Tamarind was associated with higher diastolic blood pressure (BP) in females. Conclusion: The study suggests that moderate to high consumption of Tamarind may have a negative impact on HTN among both males and females. Although Tamarind is highly valued for its pulp and offers some health benefits, its potential negative impact on HTN should be taken into consideration
Metabolic syndrome severity score in the middle-aged and elderly Iranian population: A cross-sectional survey of Bandare-Kong Cohort Study (the findings of PERSIAN Cohort Study)
No full textBackgroundMetabolic syndrome (MetS) is defined as the presence of several metabolic risk factors. The traditional MetS criteria have been considered insufficient for evaluating individuals at risk. MetS has always been categorized using binary criteria, which deny that the risk associated with MetS is likely to exist as a continuum. Also, MetS may present differently depending on age, sex, race, or ethnicity. We aimed to derive age-sex-specific equations for MetS severity scores within a southern Iranian population.MethodsThis study used first-phase data from the Bandare-Kong Non-Communicable Diseases (BKNCD) Cohort Study as part of the Prospective Epidemiological Research Studies in IrAN (PERSIAN). After exclusion of the pregnant women, diabetic patients, and individuals taking antihypertensive, antihyperlipidemic, and antidiabetic medications, 2,735 individuals aged 35 to 70 years were selected for analysis. The diagnosis of MetS was based on the National Cholesterol Education Program (NCEP) criteria for the Iranian population. Confirmatory factor analysis (CFA) was performed to formulate MetS severity scores. The receiver operating characteristic (ROC) analysis was performed to validate MetS severity score equations for age-sex-specific categories.ResultsTriglyceride had the highest factor loading range in all age-sex categories for determining the MetS severity score. Conversely, systolic blood pressure and fasting plasma glucose (FPG) exhibited the lowest factor loadings across all age-sex groups. In both sexes, when age was considered, systolic blood pressure and FPG factor loadings were less significant among subjects aged ≥45 and 35–44 years, respectively.ConclusionMetS severity scores might be more applicable than the current criteria of MetS. Prospective population-based studies should be conducted to assess the accuracy and validity of the MetS severity score for predicting cardiometabolic diseases
Urine-Based Nested PCR for the Diagnosis of Mycobacterium tuberculosis: A Comparative Study Between HIV-Positive and HIV-Negative Patients
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