200 research outputs found
Repurposing FDA approved drugs against monkeypox virus DNA dependent RNA polymerase: virtual screening, normal mode analysis and molecular dynamics simulation studies
No full textZoonotic monkeypox disease, caused by the double-stranded DNA monkeypox virus, has become a global concern. Due to the absence of a specific small molecule drug for the disease, this report aims to identify potential inhibitor drugs for monkeypox. This study explores a drug repurposing strategy using virtual screening to evaluate 1615 FDA approved drugs against the monkeypox virus DNA dependent RNA polymerase subunit A6R. Normal mode analysis and molecular dynamics simulation assessed the flexibility and stability of the target protein in complex with the top screened drugs. The analysis identified Nilotinib (ZINC000006716957), Conivaptan (ZINC000012503187), and Ponatinib (ZINC000036701290) as the most potential RNA polymerase inhibitors with binding energies of - 7.5 kcal/mol. These drugs mainly established hydrogen bonds and hydrophobic interactions with the protein active sites, including LEU95, LEU90, PRO96, MET110, and VAL113, and residues nearby. Normal mode analysis and molecular dynamics simulation confirmed the stability of interactions between the top drugs and the protein. In conclusion, we have discovered promising drugs that can potentially control the monkeypox virus and should be further explored through experimental assays and clinical trials to assess their actual activity against the disease. The findings of this study could lay the foundation for screening repurposed compounds as possible antiviral treatments against various highly pathogenic viruses
A modular tooling set-up for incremental sheet forming (ISF) with subsequent stress-relief annealing under partial constraints
No full textAmbiguity and Technique in Three NOvels by Graham Greene
Get PDFGraham Greene's complex protagonists remain sympathetic before the reader in spite of serious flaws. They are not "good" or "bad" characters, but simply human; their wrong actions become mixed with ambiguous motives, and the reader is left with more questions than answers. It is a careful technique by which the author creates such ambiguity around his protagonists. Greene's choices in narrative style show the protagonists' motives and actions from many different perspectives; thus he avoids the "easy" answers. The same narrative style, however, gives the reader a unique and intimate perspective from which to view the protagonists, resulting in the relationship which enables the reader to see, in Scobie's words, the heart of the matter. As a result, the reader discovers that there is much good in a character with immense problems and withholds judgment on even the worst offender. Though ambiguous in many ways, the protagonists are accepted as simply human. This study attempts to examine the ambiguity of Greene's protagonists and the technique that lies beneath it.Master of Arts (MA
Comparative efficacy of various indigenous and allopathic drugs against fasciolosis in buffaloes.
Get PDFU osamnaest nadziranih pokusa bilo je uključeno 180 bivola, radi usporedbe djelotvornosti nekih biljnih pripravaka protiv fascioloze i triklabendazola. Od biljnih lijekova istražena je djelotvornost sjemenki biljke Nigella sativa, zračnih dijelova Fumaria parviflora, sjemenki Caesalpinia crista i korijenja Saussurea lappa. Djelotvornost je bila procijenjena na osnovi razlike u broju jajašaca po gramu fecesa (JGF) prije i poslije liječenja. Sjemenke Niggela sativa smanjile su JGF za 54,16% nakon jedne doze od 30 mg/kg tjelesne mase, za 57,4% nakon jedne doze od 40 mg/kg te za 58,33% nakon jedne doze od 50 mg/kg tjelesne mase. Nakon druge doze od 30, 40, ili 50 mg/kg tjelesne mase uočeno je smanjenje JGF za 79,16%, 80,85% i 81,25%. Zračni dijelovi Fumaria parviflora u količini od 40, 50 odnosno 60 mg/kg tjelesne mase smanjili su JGF za 50,0%, 57,44% odnosno 78,72%, dok je primjenom dvije doze u istim količinama smanjen JGF za 82,6%, 89,36% i 95,74%. Sjemenke Caesalpinia crista smanjile su JGF za 48,9% nakon jedne doze od 30 mg/kg tjelesne mase, za 50,0% nakon jedne doze od 40 mg/kg tjelesne mase te za 57,7% nakon jedne doze od 50 mg/kg tjelesne mase dok je smanjenje JGF nakon dvije doze od 30, 40 i 50 mg/kg tjelesne mase bilo za 80,0%, 84,09% i 86,6%. Primjena Saussurea lappa u količini od 50, 100 i 200 mg/kg tjelesne mase smanjila je JGF za 46,6%, 57,4% i 61,7% nakon jedne doze, a nakon dvije doze za 62,6%, 72,3% i 78,7%. Primjena jedne doze triklabendazola od 10 mg/kg tjelesne mase smanjila je JGF za 82,6%, a primjena dviju doza za 95,7%. Redoslijed učinkovitosti pretraženih pripravaka je sljedeći: triklabendazol, Fumaria parviflora, Caesalpinia crista, Nigella sativa i Saussurea lappa. Nikakve nuzpojave nisu zapažene kod primjene biljnih pripravaka.One hundred and eighty buffaloes were used in 18 controlled experiments to compare the efficacy of certain indigenous drugs, including Nigella sativa seeds, Fumaria parviflora aerial parts, Caesalpinia crista seeds, and Saussurea lappa roots with triclabendazole against fasciolosis. Efficacy was quantified by determining the difference of eggs per gram faeces (EPG) pre- and post-treatment. Nigella sativa seeds, after a single dose of 30, 40 and 50 mg/kg body mass, reduced EPG by 54.16, 57.4 and 58.33 per cent, respectively. After the second dose the respective reduction in EPG was 79.16, 80.85 and 81.25 per cent. Fumaria parviflora aerial parts at a rate of 40, 50 and 60 mg/kg body mass were 50.0, 57.44 and 78.72 per cent, respectively, whereas efficacy at two dose levels with the same dose rate was 82.6, 89.36 and 95.74 per cent, respectively. Caesalpinia crista seeds at 30, 40 and 50 mg/kg body mass were 48.9, 50.0 and 57.7 per cent effective, respectively, whereas efficacy at two dose levels was 80.0, 84.09 and 86.6 per cent, respectively. Saussurea lappa at a rate of 50, 100 and 200 mg/kg body mass was 46.6, 57.4 and 61.7 per cent effective, respectively, at one dose level and was 62.2, 72.3 and 78.7 per cent effective at two dose levels. Triclabendazole at one dose level at a rate of 10 mg/kg body mass was 82.6 per cent effective and at two dose levels it was 95.7 per cent effective. The efficacy order was triclabendazole, Fumaria parviflora, Caesalpinia crista, Nigella sativa, and Saussurea lappa. No side effects were noted due to the use of any of these plant-origin drugs
A Variant Edition of Henry James's The Wings of the Dove
No full textMany pages appear darker than others because of necessary rescanning.In 1908, Henry James prepared a revised version of The Wings of the Dove {1902) as part of the New York Edition of his works. Despite the notoriety of James's habit of revision, and despite the high critical status of the novel as one of James's major works, no scholarly edition of the novel exists. This study attempts to supply such an edition by presenting the text of the first printing of The Wings of the Dove, together with a complete list of substantive variants in the two other editions supervised by the author. There are three forms in which the text of The Wings of the Dove is available: the first American edition (Scribner's, 1902); the first English edition (Constable, 1902); and the New York Edition (Scribner's, 1909). This study refers to these three editions as A, C and N, respectively. The history of the text shows that A, while the first to be published, is not the first printed; moreover, it lacks some of the final corrections which James made in his proofsheets of C. Hence, C, the first text to be printed and the one which contains all of his corrections of 1902, has been chosen as the copy-text for this edition. In addition to a brief discussion of the textual variants, the introduction to this edition presents all the available authorial aids to understanding the novel. Acomplete history of James's composition and publication of The Wings of the Dove, from his first Notebook entries of 1894 to the revision of the novel in 1908, is reconstructed here from published and unpublished letters of the period. A section devoted to analysis of James's epistolary comments on the novel and of his one published critique, the Preface to the New York Edition of The Wings of the Dove_, reveals inconsistencies which are ultimately related to the long and intermittent period over which the novel was composed. Finally, examination of some of James's revisions leads to the conclusion that most of the substantive variants are stylistic in effect, but that the remainder clarify or add to the meaning of particular passages. The text of the first English edition of The Wings of the Dove (C) is reproduced here as this edition's reading text. The correct forms of misprints in C are given in the lateral margins. The substantive variants in A and Nare listed in the lower margins of the pages on which the orginal text appears. This variant edition presents, for the first time, and in convenient form, all the authorial versions of the text of The Wings of the Dove.Doctor of Philosophy (PhD
The Bureaucratic disconnect in collaborative institutions: A Case of Rural Water Supply in Punjab, Pakistan
Get PDFThe collaborative model for rural water supply (RWS), introduced at the behest of international funders in the 1990s, experienced only partial success owing to the low accept- ability of public managers and the slow process of community development (CD). This article goes into the empirical findings of a study that is based on in-depth interviews with 20 staff and line public managers of the four RWS in different regions as well as on content analysis of policy documents and funding organizations’ reports. The results indicate that appropriate CD, reforms in internal organization arrangements, and understanding of context-specific social, economic, and political diversity remain necessary in collaborative compliance with institutions for RWS sustainability. The study aims at making a contribution to the theory of collaborative governance and the practice of collaborative implementation in developing countries
Hemorrhoid with a melanocytic nevus [7]
No full text[No abstract available]BRADY MS, 1995, DIS COLON RECTUM, V38, P146, DOI 10.1007-BF02052442; CLEMMENSEN OJ, 1991, HISTOPATHOLOGY, V18, P237, DOI 10.1111-j.1365-2559.1991.tb00831.x; Felz MW, 2001, SOUTHERN MED J, V94, P880; Maqbool A, 2004, CUTIS, V73, P409; MORENO SE, 2005, CLIN TRANSL ONCOL, V7, P1711
Epidemiological studies of paramphistomosis in cattle
Get PDFProvedena su epizootiološka istraživanja paramfistomoze u goveda na klaonicama, farmama, veterinarskim klinikama i manjim gospodarstvima pod različitim uvjetima držanja i klime na području Punjaba. Invadiranost je istražena u četiri različite skupine goveda. Na klaonicama je pronađeno 7,83% invadiranih goveda, dok je na farmama taj broj bio nešto veći i iznosio je 12,33%. Među govedima na klinikama svega 7,17% životinja bilo je invadirano. Najmanji broj invadiranih goveda (4,25%) dokazan je u manjim gospodarstvima. U jesenjim mjesecima zabilježena je najveća učestalost u goveda s farmi (26%) i klaonica (14,50%). U goveda s klinika ljeti je dokazana učestalost od 9,75%. Najmanji broj invadiranih goveda dokazan je zimi u malim obiteljskim gospodarstvima (2,5%). Treba naglasiti da je najveća invadiranost zabilježena u goveda mlađih od 2 godine. Mužjaci su bili češće invadirani od ženki. Terenskim istraživanjima na istom području dokazani su posrednici, puževi iz rodova Bulinus, Lymnaea i Planorbis.Epidemiological studies were undertaken at slaughter houses, live stock farms, veterinary hospitals and on household buffaloes under different management and climatic conditions in four different districts of the Punjab province. Infection rate was 7.83%, 12.33%, 7.17% and 4.25% respectively in the cattle at the slaughter house, live stock farm, veterinary hospital and at household cattle. Overall the highest prevalence in terms of season, 26% and 14.50%, was recorded during autumn at live stock farms and slaughtered cattle followed by 9.75% veterinary hospitals during summer and the lowest (2.5%) in household cattle was recorded during winter. It was observed that a higher infection rate was recorded in younger cattle (below two years of age) than older (above two years of age). Male cattle were more commonly affected than females. Snails belonging to genera Bulinus, Lymnaea and Planorbis were observed which are responsible for the transmission of paramphistomosis
Epidemiology of fasciolosis in buffaloes under different managemental conditions.
Get PDFEpizootiološka istraživanja fascioloze u bivola držanih pod različitim klimatskim uvjetima na području Punjaba provedena su na klaonicama, većim farmama, manjim seoskim gospodarstvima i na veterinarskim klinikama. Učestalost invazije u zaklanih bivola iznosila je 25,59%, u bivola s farmi 26,16%, veterinarskih klinika 13,7% te malih seoskih gospodarstava 10.5%. Najveća učestalost ustanovljena je u jesen (24,0%), zatim u proljeće (20,0%) te zimi (13,0%), dok je najmanji postotak invadiranih životinja (9,0%) utvrđen u ljetnom razdoblju. Istraživanjem je potvrđeno da su češće bile invadirane starije životinje. Nisu utvrđene razlike učestalosti po spolu.Epidemiological studies were undertaken at slaughter houses, livestock farms, veterinary hospitals and on household buffaloes under the different climatic conditions existing in Punjab province. Infection rate was 25.59, 26.16, 13.7 and 10.5 per cent, respectively in slaughtered buffaloes, buffaloes at livestock farms, veterinary hospitals and in household buffaloes. Overall highest (24.0%) seasonal prevalence in all types of buffaloes was recorded during autumn, followed by spring (20.0%), winter (13.0%). While the lowest (9.0%) was recorded during summer. It was noticed that a higher infection rate was recorded in older buffaloes than in youngsters (below 2 years of age) where as sex showed no significant difference. Buffaloes of either sex are equally affected
- …
