3 research outputs found
Impact of gabapentinoids’ reclassification policy and COVID-19 on gabapentinoids’ utilization pattern and their associated mortality in Scotland and Northern Ireland : a segmental regression analysis
No full textBackground: Gabapentinoids are commonly used for neuropathic pain but are increasingly linked with misuse/mortality. In 2019, the UK reclassified them as Schedule 3 controlled drugs. The onset of the COVID-19 pandemic created additional uncertainty regarding their utilization. We aimed to examine the impact of reclassification and COVID-19 on gabapentinoid utilization and related mortality in Scotland and Northern Ireland (NI). Research design/methods: A population-based, cross-national study was conducted using prescribing datasets (April/2018–February/2025). Utilization was measured as total items dispensed per 1,000 inhabitants and defined daily doses per 1,000 inhabitants/day. Gabapentinoid-related mortality data were analyzed in parallel. Segmented regression assessed changes in trends following the 2019 reclassification and two COVID-19 lockdowns. Results: Overall utilization was higher in Scotland than NI. In Scotland, pregabalin prescribing significantly increased over the study period, while NI demonstrated a decline, largely attributable to formulary restrictions. Neither reclassification nor pandemic lockdowns were associated with statistically significant changes in prescribing patterns. Mortality rates showed no significant correlation with utilization in either country. Conclusions: Gabapentinoid utilization does not appear to have been significantly affected by the reclassification or by COVID-19. Cross-national differences underscore the influence of formulary guidance, highlighting the need for harmonized policies/patient-level research to inform safe prescribing
Impact of gabapentinoids' reclassification policy and COVID-19 on gabapentinoids' utilization pattern and their associated mortality in Scotland and Northern Ireland: a segmental regression analysis.
No full textBACKGROUND: Gabapentinoids are commonly used for neuropathic pain but are increasingly linked with misuse/mortality. In 2019, the UK reclassified them as Schedule 3 controlled drugs. The onset of the COVID-19 pandemic created additional uncertainty regarding their utilization. We aimed to examine the impact of reclassification and COVID-19 on gabapentinoid utilization and related mortality in Scotland and Northern Ireland (NI).
RESEARCH DESIGN/METHODS: A population-based, cross-national study was conducted using prescribing datasets (April/2018-February/2025). Utilization was measured as total items dispensed per 1,000 inhabitants and defined daily doses per 1,000 inhabitants/day. Gabapentinoid-related mortality data were analyzed in parallel. Segmented regression assessed changes in trends following the 2019 reclassification and two COVID-19 lockdowns.
RESULTS: Overall utilization was higher in Scotland than NI. In Scotland, pregabalin prescribing significantly increased over the study period, while NI demonstrated a decline, largely attributable to formulary restrictions. Neither reclassification nor pandemic lockdowns were associated with statistically significant changes in prescribing patterns. Mortality rates showed no significant correlation with utilization in either country.
CONCLUSIONS: Gabapentinoid utilization does not appear to have been significantly affected by the reclassification or by COVID-19. Cross-national differences underscore the influence of formulary guidance, highlighting the need for harmonized policies/patient-level research to inform safe prescribing
Kompozitinių plienbetoninių perdangų vibracijų tyrimai.
No full textDevelopments in lightweight steel-concrete composite floors with long spans are resulting in structures with low natural frequencies. Potentially, these floors are sensitive to vibration issues. Vibrations are mostly caused by human activities on the floor. However, vibrations due to mechanical systems can also cause problems. This thesis analyses approaches on how to manually calculate natural frequency and dynamic response of slim composite floors by using available design guidelines. Composite slim steel-concrete floors with hollow-core slabs are chosen in the analysis because they are one of the most popular on construction market nowadays. Additionally, Finite Element Method software (i.e. SCIA Engineer and Autodesk Robot Structural Analysis) is used to determine the dynamic properties of these floors. Moreover, the author has created nomographs to calculate the natural frequency of floor elements much easier with less calculation. Finally, all results from the manual and numerical calculations, as well as nomographs are compared and concluded
