59 research outputs found
Numerical and experimental analysis of metamaterials with quasi-zero effect for vibration isolation
No full textMulti-omics “upstream analysis” of regulatory genomic regions helps identifying targets against methotrexate resistance of colon cancer
No full textAbstractWe present an “upstream analysis” strategy for causal analysis of multiple “-omics” data. It analyzes promoters using the TRANSFAC database, combines it with an analysis of the upstream signal transduction pathways and identifies master regulators as potential drug targets for a pathological process. We applied this approach to a complex multi-omics data set that contains transcriptomics, proteomics and epigenomics data. We identified the following potential drug targets against induced resistance of cancer cells towards chemotherapy by methotrexate (MTX): TGFalpha, IGFBP7, alpha9-integrin, and the following chemical compounds: zardaverine and divalproex as well as human metabolites such as nicotinamide N-oxide
Archaeological heritage of Tatarstan and the issues of its study and preservation
No full text© 2019 Tatarstan Academy of Sciences (TAS). The author considers the issues of study and preservation of such important cultural heritage sites as archaeological monuments. A total of over 5 thousand monuments have been identified and examined in Tatarstan, and they represent a vast source of information on the history of people inhabiting the territory of the Middle Volga region. The author have determined the directions for preservation of the archaeological heritage for our descendants and their introduction into contemporary life. State historical and cultural expert review conducted in the area of earthworks during construction, restoration, reconstruction, oil and gas development activities have allowed to bring the preservation of archaeological heritage to a higher level. International principles for the cultural heritage preservation are being actively implemented
СЛОВО ОБ УЧИТЕЛЕ: Е.П. БАРЫШНИКОВ
No full textMemories of personal meetings of the author with E.P. Baryshnikov, the scientist-literary critic, the teacher, the researcher of creativity L.N. Tolstoy, F.M. Dostoyevsky, I.S. Turgenev are given in article, his scientific biography is stated, the assessment of his contribution in formation of a modern tolstovedeniye is given. The author remembers personal and professional qualities of the scientist.Приводятся воспоминания о личных встречах автора с Е.П. Барышниковым, ученым-литературоведом, педагогом, исследователем творчества Л.Н. Толстого, Ф.М. Достоевского, И.С. Тургенева, излагается его научная биография, дается оценка его вклада в становление современного толстоведения. Автор вспоминает о личных и профессиональных качествах ученого
Application of Vibration Isolators with a Low Stiffness for the Strongly Vibrating Equipment
No full textAbstractThe paper dwells upon vibration isolators with a low or quasi-zero stiffness. They can provide a low natural frequency less than 1Hz. Different materials for manufacturing were analyzed. Various vibration isolators with quasi-zero stiffness with operating load from 1kg to 1000kg have been calculated. The scheme of installation of invented vibration isolator with a quasi-zero stiffness is offered. Calculations of the working lifetime for a vibration isolator were conducted
Codification of the Law of International Treaties (to the 40<sup>th</sup> Anniversary of the Vienna Convention on International Treaties)
No full textThe article is devoted to the 40th anniversary of the Vienna Convention on International treaties. The author follows closely the milestones in the process of working out the Convention and shows how it effects the codification of the Law of International Treaties. He describes the work of the UN Commission of International Law over such topics as “Reservations to International Treaties”, “The effect of military conflicts on International Treaties”, “Treaties through the prism of times”
European hydrogen market and its potential for Russian business
No full textIn this article, the author explores the European hydrogen market and its potential for Russian business. Hydrogen is becoming increasingly important in the pursuit of sustainability and environmental cleanliness. The author discusses the opportunities that open up for Russian companies in the European hydrogen market and highlights their expertise and experience in the production and supply of hydrogen. The results of the study indicate the prospects and potential for Russian business in this area and offer recommendations to develop this market and strengthen the positions of Russian companies
Problems of Bashkir novels of the 1950s and 1960s
No full textThe article describes the development of the Bashkir prose in the 1950s–1960s against the backdrop of socio-historical changes during the "thaw", increased attention to man as a personality. Through the analysis of the principles of realistic reflection, the study of genre and stylistic features and the identification of problems of large epic forms, the study revealeda tendency of the gradual transition of Bashkir novelism from sociological research to psychologically reliable depiction of the spiritual world of contemporaries.The humanistic nature of the Bashkir literature of the 1960s was manifested in attention to the individual, development of new personality traits, high spiritual and moral relations between people.The novels of the 1950s–1960s raised problems of the then reality and achieved significant success in depicting full-blooded, life-like typical characters, individual images. The connection between the writer and the reality was strengthened. Having accumulated experience in creating novels, back in the 20–30s of the twentieth century,Bashkir prose continued the traditions in a deep and truthful coverage of the current problems multiplying and enriching literature with new works, styles, and contemporary images. The writers paid close attention to the inner world, the psychological portrait (“May Rain” and “Wild Rose Flower” by A. Valeev, “Generous Land” by D. Islamov, “People of Long Roads” by N. Musin, “How the Stars Light up” by Y. Khammatov, “Eagles do not leave nests” by Y. Valeeva, “Night on the New Moon” by G. Ibragimov, “I do not promise you paradise” by A. Bikchentaeva and others
Formation of Iranian studies at the Kazan university (19th-early 20th centuries)
No full text© the author(s). The article involves the historical and scientific study of the Iranian Cultural Heritage in Russia in the 19th century. It presents the background of the Persian language and literature teaching at Russian universities. Initiators and the ways the Iranian Studies developed at the Kazan University are mentioned. The historical events dealing with political and cultural relations of the peoples of the Volga-Ural region and Iran are summarized. It focuses on a variety of materials, covering the events, the heritage of Orientalists and Iranian scholars and results in the formation of Iranian Studies at the Kazan University in the 19th century. This research will provide valuable information regarding scientific and educational activities of Orientalists of the University, associated with teaching the Persian language, linguistic, literary, historical, ethnographic studies of the history and culture of Iran
Formation of Iranian studies at the Kazan university (19th-early 20th centuries)
No full text© the author(s). The article involves the historical and scientific study of the Iranian Cultural Heritage in Russia in the 19th century. It presents the background of the Persian language and literature teaching at Russian universities. Initiators and the ways the Iranian Studies developed at the Kazan University are mentioned. The historical events dealing with political and cultural relations of the peoples of the Volga-Ural region and Iran are summarized. It focuses on a variety of materials, covering the events, the heritage of Orientalists and Iranian scholars and results in the formation of Iranian Studies at the Kazan University in the 19th century. This research will provide valuable information regarding scientific and educational activities of Orientalists of the University, associated with teaching the Persian language, linguistic, literary, historical, ethnographic studies of the history and culture of Iran
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