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Influence of fast advective flows on pattern formation of <i>Dictyostelium discoideum</i> - Fig 15
Get PDFa) Uniform cell distribution at the beginning of experiment in a flow-through microfluidic channel (Vf = 10 mm/min). b) During the propagation of the waves, the variations in cell density due to chemotactic cell movement are still negligible. c) Aggregation patterns after 8 hours starvation show cone-shaped structures with long streams downstream of the centers. d) Lateral streams, extended almost 0.5 mm in y-direction, start to line up in the direction of flow.</p
Snapshots of membrane’s protrusion with a wider actin brush underneath the membrane.
No full textUpon distribution of actin filaments on a larger region, we obtain lamellipodium-like protrusions for (a) non-progressive and (b) progressive gel boundary. Total number of filaments is 101 and the parameters are , Fe = 12 pN, and na = 0.02 nm−1.</p
Comparison of membrane deformations between progressive versus non-progressive gel boundary.
No full text(a) In the case of non-progressive gel front, the final steady configuration is established much earlier and the final membrane elongation is smaller than a progressive gel front. Here , Fe = 12 pN and for progressive gel scenario.</p
Filament distribution in the system with non-progressive gel boundary.
No full textThe probability distribution of (a) detached and (b) attached filaments for the early state and also the probability distribution of (c) detached and (d) attached filaments for the late stage of the whole movement. This is the result for a system of na = 0.1 nm−1, Fe = 12 pN and . The total number of filaments is constant and equal to 25 during the whole process. Here μ and σ are the mean value and standard deviation of a normal distribution fitted to the data.</p
List of parameters used in our simulations.
No full textList of parameters used in our simulations.</p
Final steady state configuration of the membrane is reached faster in the case of non-progressive gel for different values of edge tension.
No full textThe dynamics of membrane’s middle point versus time for different values of edge tension Fe = [4, 8, 12, 16, 20] pN, with filaments polymerization rate equal to . (a) Non-progressive versus (b) progressive gel boundary with .</p
Membrane deformation in the regime of progressive gel.
No full text(a) Initial (b) early and (c) late configuration of the membrane and gel for na = 0.1 nm−1, Fe = 12 pN, and . The insets in panels (a)-(c) show the filaments status underneath the membrane. The blue lines represent the free fluctuating filaments while the black lines show the attached filaments. (d) Behavior of the middle-point of the membrane versus time. The little arrows show the points where the data for the (a)-(c) plots are collected.</p
Force distribution in the system with non-progressive gel front.
No full textForce distribution of detached actin filaments in (a) early stages, (b) late stages of the protrusion. The attached force distribution of actin in (c) early stages and (d) late stages of the total movement. Here μ and σ are mean value and standard deviation of a normal distribution fitted to the data.</p
Mean quantities for the case of progressive gel front.
No full text(a) Actin filaments status during the whole evolution for the case of active gel. We have 25 filaments in the system which are shown in the horizontal axis. The blue color shows the detached status of the filament and the black shows the attached status. (b) The average force exerted by attached and detached filaments on the membrane as a function of simulation time. (c) The mean attachment and detachment time of the filaments versus time.</p
Model scheme.
No full text(a) Schematic representation of semiflexible region and actin gel in the model. (b) Magnification of three neighboring beads on the membrane plus the shaded area used for energy minimization. The faded filled circle represents the new position of the bead and defines the displacement vector . (c, d) Stretched and compressed configurations of an attached filament exerting pulling or pushing forces on the membrane. (e) An unattached filament is bent under the membrane and exert entropic force fd.</p
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