177,534 research outputs found
VOLTAMMETRIC BEHAVIOR OF BOVINE ERYTHROCYTE SUPEROXIDE-DISMUTASE
No full textVOLTAMMETRIC BEHAVIOR OF BOVINE ERYTHROCYTE SUPEROXIDE-DISMUTASE WAS INVESTIGATED IN AQUEOUS SOLUTIO
Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses
No full textFollowing an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied
Epigenetics meets immune checkpoints
No full textEpigenetic alterations play a pivotal role in cancer development and progression. Pharmacologic reversion of such alterations is feasible, and second generation "epigenetic drugs" are in development and have been demonstrated to possess significant immunomodulatory properties. This knowledge, together with the availability of new and highly effective immunotherapeutic agents including immune checkpoint(s) blocking monoclonal antibodies, allows us to plan for highly innovative proof-of-principle combination studies that will likely open the path to more effective anticancer therapies. (C) 2015 Elsevier Inc. All rights reserved
Intern experience at CH���M Hill, Inc.: an internship report
No full textIncludes author's vita"Submitted to the College of Engineering of Texas A&M University in partial
fulfillment of the requirement for the degree of Doctor of Engineering."Includes bibliographical referencesA review of the author's internship experience with CH���M HILL, Inc.
during the period September 1975 through May 1976 is presented. During this nine month
internship the author worked as an Engineer II in the Industrial Processes discipline of this
large consulting engineering firm... The author's prime responsibility was as one of three
lead design engineers on the design of a large wastewater treatment facility for a pulp mill
in Hoquiam, Washington owned by ITT Rayonier Inc. The work generally consisted of the design
of individual treatment units and associated piping and pumping. The purpose of the project
was to provide wastewater treatment capabilities that would satisfy the effluent limitations
(standards) imposed upon the mill by the State of Washington Department of Ecology and the
U.S. Environmental Protection Agency. The author's assignment also entailed necessary
interaction with the project manager and other CH���M HILL design engineers and support staff
members, the client's representatives, and representatives of two other consulting engineering
firms working on the project. Thus, the internship position at CH���M HILL provided considerable
experience coordinating the author's work with the work of other engineers, guiding the design
and administrative efforts of a support staff, and interacting regularly with the client and
other consulting firms. This broad exposure to a variety of engineering and organizational
problems provided a valuable educational experience
Intern experience at the Texas Transportation Institute: an internship report
No full text"Submitted to the College of Engineering of Texas A&M University in partial
fulfillment of the requirements for the degree of Doctor of Engineering."Includes vita (leaf 91)Includes bibliographical references (leaf 57)This report discusses the author's engineering experience at the Texas
Transportation Institute (TTI), Texas A&M University from March 1974 through July 1977. A
report of this experience plus twelve additional hours of academic course work were
substituted for an internship according to requirements established by the College of
Engineering. Although the author could not retroactively establish objectives of the type
associated with a typical internship, the work experience gained could be related to the two
general objectives of an intership: 1. To demonstrate an identifiable contribution to the
organization in which the intern served, and 2. To enable the intern to become aware of the
non-technical aspects of working as an engineer in a non-academic environment. While a member
of the Texas Transportation Institute staff, the author worked on a number of projects in the
areas of highway traffic engineering research and the preparation of continuing education
courses for transportation engineering officials. These assignments were contained within the
Urban Transportation Systems Division of TTI. This report delineates the author's contribution
to four particular projects and discusses the technical as well as non-technical experience
gained from each. Having been exposed to more engineering situations than many of the other
Doctor of Engineering students, the author has already formulated some rather specific
milestones for the future. The Doctor of Engineering program is discussed in conjunction with
its potential for helping the author attain these career goals and objectives. Also, some
thoughts are presented regarding the Doctor of Engineering as a viable alternative to the
Ph.D. in preparing for a career in engineering higher education
Antitumor Activity and Multi-Target Mechanism of Phenolic Schiff Bases Bearing Methanesulfonamide Fragments: Cell Cycle Analysis and a Molecular Modeling Study
No full textFive phenolic Schiff bases (7–11) incorporating a fragment of methanesulfonamide were synthesized and evaluated for their efficacy as antitumor agents. Compounds 7 and 8 demonstrated the most potent antitumor action, with a positive cytotoxic effect (PCE) of 54/59 and 59/59 and a mean growth percentage (MG%) of 67.3% and 19.5%, respectively, compared with imatinib (PCE = 20/59 and MG% = 92.6%). The PCE values for derivatives 9–11 were 3/59, 4/59, and 4/59, respectively, indicating poor antitumor effect. Compound 8 exhibited the most significant efficacy, suppressing cell proliferation by an average of 50% at a dosage of 0.501 μM, in comparison with the reference drugs sorafenib (2.33 μM), gefitinib (2.10 μM), erlotinib (7.68 μM), and celecoxib (17.5 μM). Compounds 7 and 8 had substantial inhibitory effects on the human epidermal growth factor receptor 2 (HER2), with IC50 values of 0.183 μM and 0.464 μM, respectively. Furthermore, they exhibited significant inhibition of the epidermal growth factor receptor (EGFR), with IC50 values of 0.752 μM and 0.166 μM, respectively. Compound 8 exhibited the highest COX-2 inhibition (IC50 = 12.76 μM). We performed molecular docking dynamic experiments to examine the precise interaction and structural prerequisites for the anticancer activity of derivatives 7 and 8 by targeting EGFR and HER2
The long-wavelength view of GG Tau A: rocks in the ring world
No full textWe present the first detection of GG Tau A at centimetre wavelengths, made with the Arcminute Microkelvin Imager Large Array at a frequency of 16 GHz (λ = 1.8 cm). The source is detected at >6 σrms with an integrated flux density of S16GHz = 249 ± 45 µJy. We use these new centimetre-wave data, in conjunction with additional measurements compiled from the literature, to investigate the long-wavelength tail of the dust emission from this unusual protoplanetary system. We use an MCMC-based method to determine maximum likelihood parameters for a simple parametric spectral model and consider the opacity and mass of the dust contributing to the microwave emission. We derive a dust mass of Md ~ 0.1 Msun, constrain the dimensions of the emitting region and find that the opacity index at λ > 7 mm is less than unity, implying a contribution to the dust population from grains exceeding ~4 cm in size. We suggest that this indicates coagulation within the GG Tau A system has proceeded to the point where dust grains have grown to the size of small rocks with dimensions of a few centimetres. Considering the relatively young age of the GG Tau association in combination with the low derived disc mass, we suggest that this system may provide a useful test case for rapid core accretion planet formation models
DIMENSI PSIKOLOGIS PEMAKNAAN AZAB NERAKA DALAM SURAT AL-WAQI’AH (Studi Kasus Kelompok Kajian Al-Miftah Ahmad)
No full textABSTRAK
Azab neraka adalah hukuman dari Allah untuk para pendosa,
baik dari kalangan mukmin maupun non mukmin (orang-orang kafir,
munafik dan musrik). Kehidupan di dunia hanyalah sementara dan
tempat untuk bersenda gurau. Sedangkan akhirat adalah tempat
terakhir kita untuk pulang. Dalam akhirat terdapat dua pilihan dimana
semua yang kita kerjakan di dunia ada pertanggung
jawabannyayaitusurga dan neraka. Ketika kita membahas tentang azab
neraka, tidak menutup kemungkinan seseorang tidak merasakan
respon psikologis baik respon fisik atau non fisik.
Tujuan penelitian ini adalah untuk mengetahui bagaimana
pemaknaan azab neraka menurut ustadz Baha‟udin Ahmad selaku
pengajar tafsir di TPA tersebut, perbandingan makna azab neraka
dalam surat Al-Waqi‟ah yang disampaikan oleh sang ustadz dengan
tafsir yang penulis pakai yaitu Tafsir Al-Mishbah karya M. Quraish
Shihab, serta dimensi psikologis kelomok kajian TPA Al-Miftah
Ahmad yang terletak di Desa Karangsari, Kecamatan Ketapang,
Lampung Selatan terhadap penafsiran tentang azab neraka terebut.
Metode yang digunakan dalam penelitian ini adalah metode
kualitatif dengan pendekatan pustaka dan lapangan. Sumber data
penelitian ini diperoleh dari wawancara, observasi, dan dokumentasi,
dan ditinjau dari beberapa kepustakaan.
Adapun hasil penelitian ini yaitu: makna azab neraka menurut
kelompok kajian Al-Miftah Ahmad adalah suatu hukuman yang
diberikan oleh Allah untuk orang-orang yang melanggar perintah-Nya.
Dengan adanya makna tersebut dapat ditemukan perbandingan
pemaknaan azab neraka dalam surat Al-Waqi‟ah antara kelompok
kajian Al-Miftah Ahmad dengan M. Quraish Shihab, dalam kitab
tafsirnya Quraish Shihab hanya menjelaskan bentuk-bentuk azab
neraka dalam surat Al-Waqi‟ah tidak menjelakan makna dari azab
nerakanya sedangkan kelompok kajian Al-Miftah Ahmad menjelaskan
secara detail makna dan bentuk azab neraka. Respon kelompok kajian
Al-Miftah Ahmad setelah mendengar ustadz Baha‟udin Ahmad
menjelaskan tentang azab neraka bermacam-macam ada yang takut,
sedih, gelisah, bahkan sampai menangis karena teringat dosa yang
telah mereka perbuat. Semua jam‟ah mempercayai bahwa azab neraka
itu benar adanya.
Kata kunci : Azab, Makna, Psikologis
iii
ABSTRAK
The punishment of hell is a punishment from Allah for
sinners, both believers and non-believers (unbelievers, hypocrites and
polytheists). Life on earth is only temporary and a place for fun. While
the afterlife is our last place to go home. In the afterlife there are two
choices where everything we do in this world is accountable, namely
heaven and hell. When we talk about the punishment of hell, it is
possible that someone does not feel a psychological response, either a
physical or non-physical response.
The purpose of this study was to find out how the meaning of
the punishment of hell according to Ustadz Baha'udin Ahmad as a
teacher of interpretation at the TPA, the comparison of the meaning of
the punishment of hell in the letter Al-Waqi'ah delivered by the ustadz
with the interpretation that the author used, namely Tafsir Al-Mishbah
by M. Quraish Shihab, as well as the psychological dimensions of the
Al-Miftah Ahmad TPA study group located in Karangsari Village,
Ketapang District, South Lampung on the interpretation of the
punishment of hell.
The method used in this research is a qualitative method with
a literature and field approach. The data sources of this research were
obtained from interviews, observations, and documentation, and were
reviewed from several literatures.
The results of this study are: the meaning of the punishment
of hell according to the study group of Al-Miftah Ahmad is a
punishment given by Allah to those who violate His commands. With
this meaning, it can be found a comparison of the meanings of the
punishment of hell in the letter Al-Waqi'ah between the study group of
Al-Miftah Ahmad and M. Quraish Shihab, in his book of commentary
Quraish Shihab only explains the forms of the punishment of hell in
the letter Al-Waqi'ah not explained the meaning of the punishment of
hell while the study group Al-Miftah Ahmad explained in detail the
meaning and form of the punishment of hell. The response of the Al�Miftah Ahmad study group after hearing Ustadz Baha'udin Ahmad
explain about the punishment of hell varies, some are afraid, sad,
anxious, even cry because they remember the sins they have
committed. All jam'ah believe that the punishment of hell is true.
Keywords: Punishment, Meaning, Psychologica
Intern experience at Honeywell, Inc., Large Information Systems Division: an internship report
No full textIncludes author's vita"Submitted to the College of Engineering of Texas A&M University in partial
fulfillment of the requirement for the degree of Doctor of Engineering."Includes bibliographical references (leaves 169-173)This report describes the author's internship assignment at Honeywell
Inc. - Large Information Systems Division from January, 1982 through August, 1982. The purpose
of the assignment was to fulfill the internship requirements of the Doctor of Engineering
Program. During the internship, the author held the position of VLSI design engineer, where he
worked on a predefined project. The project's objective was to evaluate how circuit designs
based on an advanced CMOS process, can be applied to hardware products at LISD. The internship
allowed the author to successfully apply the MOS circuit design training, which ws developed
at Texas A&M, to an industrial project. In addition, involvement in different activities
and exposure to the various problems not encountered in academia, made this internship an
invaluable experience
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