6,255 research outputs found
Preserving the promise : improving the culture of biotech investment /
No full text"Preserving the Promise: Improving the Culture of Biotech Investment critically examines why most biotech startups fail, as they emerge from universities into an ecosystem that inhibits rather than encourages innovation. This 'Valley of Death' squanders our public investments in medical research and with them, the promise of longer and healthier lives. The authors explicate the Translation Gap faced by early stage biotech companies, the result of problematic technology transfer and investment practices, and provide specific prescriptions for improving translation of important discoveries into safe and effective therapies. In Preserving the Promise, Dessain and Fishman build on their collective experience as company founders, healthcare investor (Fishman) and physician/scientist (Dessain). The book offers a forward-looking, critical analysis of 'conventional wisdom' that encumbers commercialization practices. It exposes the self-defeating habits of drug development in the Valley of Death, that waste money and extinguish innovative technologies through distorted financial incentives. Explains why translation of biotech discovery into medicine succeeds so infrequently that it's been dubbed the Valley of Death. Uncovers specific decision-making strategies that more effectively align incentives, improving clinical and financial outcomes for investors, inventor/entrepreneurs, and patients. Examines the critical, early stages of commercialization, where technology transfer offices and Angels act as gatekeepers to development, and where tension between short-term financial and long-term clinical aspirations sinks important technologies. Deconstructs the forces driving biotech, recasts them in a proven conceptual framework, and offers practical guidance for making the system better."--Provided by publisher.Includes bibliographical references and index.Online resource; title from e-book title screen (EbscoHost platform, viewed February 23, 2017)."Preserving the Promise: Improving the Culture of Biotech Investment critically examines why most biotech startups fail, as they emerge from universities into an ecosystem that inhibits rather than encourages innovation. This 'Valley of Death' squanders our public investments in medical research and with them, the promise of longer and healthier lives. The authors explicate the Translation Gap faced by early stage biotech companies, the result of problematic technology transfer and investment practices, and provide specific prescriptions for improving translation of important discoveries into safe and effective therapies. In Preserving the Promise, Dessain and Fishman build on their collective experience as company founders, healthcare investor (Fishman) and physician/scientist (Dessain). The book offers a forward-looking, critical analysis of 'conventional wisdom' that encumbers commercialization practices. It exposes the self-defeating habits of drug development in the Valley of Death, that waste money and extinguish innovative technologies through distorted financial incentives. Explains why translation of biotech discovery into medicine succeeds so infrequently that it's been dubbed the Valley of Death. Uncovers specific decision-making strategies that more effectively align incentives, improving clinical and financial outcomes for investors, inventor/entrepreneurs, and patients. Examines the critical, early stages of commercialization, where technology transfer offices and Angels act as gatekeepers to development, and where tension between short-term financial and long-term clinical aspirations sinks important technologies. Deconstructs the forces driving biotech, recasts them in a proven conceptual framework, and offers practical guidance for making the system better."--Provided by publisher.Innovation Meets the Translation Gap. Stop the Madness and Cure Something ; Into the Valley of Death ; Clinical Promise [not]= Investment Practice ; Velcade, a Biotech Success Story ; Biotechnology and the Future of Pharma ; Why Pharma Should Care About the Valley of Death ; Porter's Five Forces and the Market for Angel Capital ; Out of the Frying Pan: The Fire's Not So Great Either ; Getting to Australia -- Translation Gap 1: Universities Don't Make What Companies Need. When Is an Experiment Ready for the Valley of Death? ; Unintended Consequences of Applying for a Patent ; What if It Doesn't Actually Work? ; Building a Better Mousetrap -- Translation Gap 2: Good Innovation Is Not Always a Good Investment. Due Diligence and Angel Incentives ; What Is Value? ; Angels at the Crux of Invention ; Investment: A Nuanced Decision ; Ready for a Long-Term Relationship With a Science Experiment? ; Investing in Hockey Sticks ; Harps for Angels ; Connecting Innovation to Investment -- Translation Gap 3: Technology Transfer Wastes Money and Innovation. Mitigating Supplier Power ; Preventing Speeding by Closing the Road ; Breaking Old Habits -- Epilogue: Why We Do This.Elsevie
Postgraduate Students Perception and Utilization of Serial Materials in South-East, University Libraries, Nigeria
No full textThe goal of this study is to learn how postgraduate students in Nigeria\u27s university libraries perceive and use serial resources. The study used a descriptive survey as its method. 295 postgraduate library and information science students from four South-East regional institutions two state universities and two federal universities make up the research population. The instrument used to collect the data was a questionnaire. Based on the study\u27s goals, a questionnaire was created. The findings show that postgraduate students have a positive perception of the use of serial materials, which includes the following: serial materials carry current information on a variety of subject areas; they are essential for researchers and students; serial contains the facts and figures needed for research; serial materials present reports of current research findings more quickly than any other publication; and serial materials represent various author\u27s ideals on a variety of subjects. The results also showed that journals, project work, and thesis were the main serials materials most frequently used. The results also showed that the following challenges were encountered: a lack of borrowing facilities or journals in my area; poor searching abilities; an unstable power supply; a lack of resources; an inconvenient opening; outdated information serials resources; a lack of manpower to effectively handle customer requests; and periodicals that are not appropriate. The findings also suggested measures for overcoming the challenges faced by the serial unit, including increased funding for the library acquisition of sufficient, up-to-date serials resources and a rise in subscription rates
Disciplinary Privilege and the Promise of Decampment: A Response to James Thuo Gathii's “The Promise of International Law: A Third World View”
No full textThis address were delivered at the 114th Annual Meeting of the American Society of International Law, in which the author served as Annual Grotius Lecture Discussant, responding to James Thuo Gathii’s Grotius Lecture: ‘The Promise of International Law: A Third World View’ (available at https://ssrn.com/abstract=3635509). They address what Third World approaches to international law (TWAIL), and the structural racism of the discipline of international law that TWAIL scholarship makes apparent, demand of scholars proceeding from other epistemic locations
The promise of Iceland
No full textMemoir, 288 pages. An account of journeys made by the author from Australia to Iceland as a way of interrogating notions of cultural belonging, family, and homecoming.\ud
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"In 1990, Kári Gíslason travelled to Iceland to meet his father for the first time. What he finds is not what he expected.\ud
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Born from a secret liaison between a British mother and an Icelandic father, Kári Gíslason was the subject of a promise – a promise elicited from his father to not reveal his identity. The Icelandic city of Reykjavík, where Kári was born, was also home to his father and his father’s wife and five children – none of whom knew of Kári’s existence. Moving regularly between Iceland and Australia, he grew up aware of his father’s identity, but understanding that it was the subject of a secret pact between his parents. At the age of 27, he makes a decision to break the pact and contacts his father’s other family. What follows, and what leads him there, makes for a riveting journey over landscapes, time and memory. \ud
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Kári travels from the freezing cold winters of Iceland to the shark net at Sydney’s Balmoral, an unsettled life in the English countryside and the harsh yellow summer of Brisbane, and back again. He traces the steps of his mother who answered an ad in The Times for an English-speaking secretary in 1970 and found herself in Iceland among the ‘Army of Foreign Secretaries’, and in the arms of a secret lover. Iceland becomes the substitute for the father Kári never really knew as he discovers the meaning of ‘home’ and closes the circle of his own fatherless life."-- publisher websit
Electronic information: promise and peril
No full textWith reference to a recent visit to Dhaka, Bangladesh, the author gives his personal view on the spread of IT technology that accompanies globalisation. He comments particularly on the communication potential of the Internet and email, and the tendency of the technology to aggravate existing inequalities.This article is hosted by our co-publisher Taylor & Francis.</p
Implementing the AIFMD: Success or failure? ECMI Commentary No. 34, 28 March 2013
No full textThis commentary considers the implementation of the Alternative Investment Fund Managers Directive (AIFMD) by the European Commission. The AIFMD creates an internal market for asset management and as an endeavour to develop market-based finance is an important piece of legislation for the European economy. The author, Mirzha de Manuel Aramendía, considers the implementation of some of the provisions that raised concern among industry participants. He finds that, on balance, a practical and flexible approach to implementation has been followed that should help secure the success of the framework, which at present is still uncertain. The commentary also considers the remuneration guidelines adopted recently by the European Securities and Markets Authority (ESMA). It encourages EU and national authorities to commit to the success of the AIFMD framework, as part of a broader effort to develop capital markets and reduce the historical reliance of the European economy on bank finance
The Essence of Promise
No full textAccording to the author the nature of promise presents a twofold problem. First refers to the question why and how an utterance may cause action; second – to the question why and how this action may cause a duteous state, or action. The conclusions drawn from these analyses can facilitate legal statements concerning the nature of promise
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A Promise Remains: A Study of Promise in the Epistle to the Hebrews
No full textDespite receiving little direct attention, the theme of promise often features in scholars’ discussions of the central themes of the Epistle to the Hebrews, with some even asserting that promise is the foundational motif of the entire work. However, the way in which the author of Hebrews portrays divine promises and uses them to contribute to the structure of his theology has not yet been satisfactorily described. What the author means by promise, how promise relates to other types of divine commitments, and the content and timing of the promise’s fulfilment all need clarification and more precise attention.
Through an exegesis of the relevant passages of Hebrews, this thesis provides a new reading of promise in Hebrews. After an exegesis of the epistle, I then describe Hebrews’ overall theology of promise. I argue that, unlike in previous analyses, rest is not the primary content of promise, nor is it the primary lens through which the other instances of promise language should be understood. On the contrary, I argue that the promise is most closely associated with the benefits promised to Abraham, and then mediated through the various subsequent covenants. Further, while previous studies have left it unclear how the divine promise relates to both the Old and New Covenants, I argue that Hebrews develops a view of salvation history in which covenants are founded upon promises and then bring those promises to fruition. This is true of both the Old and New Covenants, though in different ways. I then demonstrate the ways in which this understanding of promise sheds light on the author’s hermeneutic and on his method of achieving his hortatory purposes for the epistle. Finally, I conclude by re-asserting the consistency of the author’s thought regarding promise and by addressing questions raised by earlier studies of this theme
Some Problems With Contract as Promise
No full textThe promise theory views the origin of contract in the making of a promise. This means that it views the creation of contracts as arising, in an important part, from the voluntary acts of promisors rather than from third parties like the State. In this regard, the theory facilitates the classical liberal value of freedom to contract. The promise theory also supports the notion that contracts should be interpreted according to the terms of the promise rather than by imposing terms on the parties. In this regard, the theory facilitates the classical liberal value of freedom from contract. These strengths of the promise theory are why the author credits Professor Farnsworth--one of the leading proponents of this theory of contract--with helping to keep contract alive. By promoting the promise theory so effectively, he has helped bolster both freedom from and freedom to contract.
Yet the promise theory is not without its difficulties, though these difficulties are complex and hard to explain concisely. With this caveat in mind, however, and at the risk of substantial oversimplification, the author attempts to summarize some of the problems that arise from adhering to a promise theory of contract
Can We Hide in the Web? Large Scale Simultaneous Age and Gender Author Profiling in Social Media - Notebook for PAN at CLEF 2013
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