108 research outputs found
The Ribosome Cooperates with the Assembly Chaperone pICln to Initiate Formation of snRNPs
No full textSummaryThe formation of macromolecular complexes within the crowded environment of cells often requires aid from assembly chaperones. PRMT5 and SMN complexes mediate this task for the assembly of the common core of pre-mRNA processing small nuclear ribonucleoprotein particles (snRNPs). Core formation is initiated by the PRMT5-complex subunit pICln, which pre-arranges the core proteins into spatial positions occupied in the assembled snRNP. The SMN complex then accepts these pICln-bound proteins and unites them with small nuclear RNA (snRNA). Here, we have analyzed how newly synthesized snRNP proteins are channeled into the assembly pathway to evade mis-assembly. We show that they initially remain bound to the ribosome near the polypeptide exit tunnel and dissociate upon association with pICln. Coincident with its release activity, pICln ensures the formation of cognate heterooligomers and their chaperoned guidance into the assembly pathway. Our study identifies the ribosomal quality control hub as a site where chaperone-mediated assembly of macromolecular complexes can be initiated
ORIGINAL ARTICLE Biological Standards Survey of Radioactive Materials Concentration in Ilam City Wheat Fields Soil with Gamma Spectrometry 1 Elham Shafiei and Arash Nademi: Biological Standards Survey of Radioactive Materials Concentration in Ilam City Wh
No full textABSTRACT Radionuclide radiation can effect on the human and creature's health. Currently, soil radioactivity levels of Ilam 's wheat champs is not clear. To determine the degree of safety it's necessary to specify the activity levels of the mentioned environment for persons. HPGe detector for measuring consistency of activities and in soil samples taken from wheat was used in Ilam province. 20 soil samples from Ilam provience from wheat fields were collected during Autumn of 2009, spring 0f 2010. From each location of an approximately 10×10 area, 5 sub samples were collected. The sub sample materials were hipandthigh combined and homogenized.In soil samples, the average activity concentrations o
Studies on plant based dietary supplements for control of Aeromonas hydrophila infections in rainbow trout (Oncorhynchus mykiss Walbaum)
No full textRainbow trout (Oncorhynchus mykiss Walbaum) of average weight 18 g, were fed for
two weeks with diet supplemented with 0.5 g (= 0.5%), 1 g (= 1%) and 2 g (= 2%) 100
g-1 of lupin (Lupinus perennis), mango (Mangifera indica) and stinging nettle (Urtica
dioica), and with normal diet as controls. Following challenge with Aeromonas
hydrophila, there was a reduction in mortality compared with the controls.
Furthermore, the fish, which were fed with dietary supplements, recorded enhanced
haematological and immunological parameters including phagocytic, respiratory burst,
lysozyme, bactericidal, complement, myloperoxidase and antiprotease activities, and
total protein, compared to the controls. Feeding for 2 months with 1% and 2% of the
dietary supplements led to an increase in growth performance, body composition,
digestive enzyme (total proteases, amylase, lipase and pepsin), total protein and glucose
compared to controls, whereas there was not any effect on kidney or liver function. The
expression of IL-1ß, IL-8 and TGF- ß1 in head kidney of rainbow trout fed for 2 months
was upregulated after feeding with 1% lupin and 1% stinging nettle. In contrast, there
was not any significant effect following feeding with mango
Engineering an Optimal Wind Farm
No full textThe project covers creation of a framework for optimisation of wind farm layouts. The optimisation is done with an objective of maximising the Net Present Value of the farm. With that aim, both power production and the fatigue driven component degradation are considered. The work is split in two main parts. First, in order to circumvent the use of full DWM model simulations, surrogate models of lifetime equivalent loads and power production are created. In the second stage, an optimisation platform is assembled as a two-stage, multi-fidelity strategy encompassing genetic algorithm for global and gradient based algorithm for local optimisation. The analysis of a wind farm is performed using DWM surrogate model which significantly contributes to the speed of computations. On the other hand, the use of surrogates makes it possible to capture the in-stationary effects of wake meandering with sufficient quality. The objective of the thesis is to show the steps required in assembling a framework such as this. Moreover, through the tests performed on Middelgrunden wind farm, the aim is to show the importance of setting the number of turbines as a design variable.European Wind Energy MasterWind EnergyAerospace Engineerin
Fabrication and mechanical properties of aluminum composite reinforced with functionalized carbon nanotubes
No full textEffect of drying environment on grain size of titanium dioxide nano-powder synthesized via sol-gel method
No full textComposition, physical properties and drying characteristics of seed oil of Citrullus lanatus
No full textUse of lupin, Lupinus perennis, mango, Mangifera indica, and stinging nettle, Urtica dioica, as feed additives to prevent Aeromonas hydrophila infection in rainbow trout, Oncorhynchus mykiss (Walbaum)
No full textFeeding rainbow trout, Oncorhynchus mykiss (Walbaum), with 1% lupin, Lupinus perennis, mango, Mangifera indica, or stinging nettle, Urtica dioica, for 14 days led to reductions in mortality after challenge with Aeromonas hydrophila. In addition, there was significant enhancement in serum bactericidal activity, respiratory burst and lysozyme activity in the treatment groups compared to the controls. Use of lupin and mango led to the highest number of red blood and white blood cells in recipient fish, with use of stinging nettle leading to the highest haematocrit and haemoglobin values; the highest value of mean corpuscular volume and haemoglobin was in the control groups and those fed with stinging nettle
Studies on plant based dietary supplements for control of Aeromonas hydrophila infections in rainbow trout (Oncorhynchus mykiss Walbaum)
No full textRainbow trout (Oncorhynchus mykiss Walbaum) of average weight 18 g, were fed for two weeks with diet supplemented with 0.5 g (= 0.5%), 1 g (= 1%) and 2 g (= 2%) 100 g-1 of lupin (Lupinus perennis), mango (Mangifera indica) and stinging nettle (Urtica dioica), and with normal diet as controls. Following challenge with Aeromonas hydrophila, there was a reduction in mortality compared with the controls. Furthermore, the fish, which were fed with dietary supplements, recorded enhanced haematological and immunological parameters including phagocytic, respiratory burst, lysozyme, bactericidal, complement, myloperoxidase and antiprotease activities, and total protein, compared to the controls. Feeding for 2 months with 1% and 2% of the dietary supplements led to an increase in growth performance, body composition, digestive enzyme (total proteases, amylase, lipase and pepsin), total protein and glucose compared to controls, whereas there was not any effect on kidney or liver function. The expression of IL-1ß, IL-8 and TGF- ß1 in head kidney of rainbow trout fed for 2 months was upregulated after feeding with 1% lupin and 1% stinging nettle. In contrast, there was not any significant effect following feeding with mango.EThOS - Electronic Theses Online ServiceGBUnited Kingdo
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