107 research outputs found
Correction to: Growth Factors and Neuroglobin in Astrocyte Protection Against Neurodegeneration and Oxidative Stress (Molecular Neurobiology, (2019), 56, 4, (2339-2351), 10.1007/s12035-018-1203-9)
No full textThe original version of this article unfortunately contained a typo error. The name of author “Ghulam Md Ashrad” should be written as “Ghulam Md Ashraf”. The authors hereby correct the name as displayed above. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.Universidad Autónoma de Chil
Dihydroartemisinin-piperaquine versus chloroquine to treat vivax malaria in Afghanistan: an open randomized, non-inferiority, trial.
No full textBACKGROUND: Afghanistan's national guidelines recommend chloroquine for the treatment of Plasmodium vivax infection, the parasite responsible for the majority of its malaria burden. Chloroquine resistance in P. vivax is emerging in Asia. Therapeutic responses across Afghanistan have not been evaluated in detail.
METHODS: Between July 2007 and February 2009, an open-label, randomized controlled trial of chloroquine and dihydroartemisinin-piperaquine in patients aged three months and over with slide-confirmed P. vivax mono-infections was conducted. Consistent with current national guidelines, primaquine was not administered. Subjects were followed up daily during the acute phase of illness (days 0-3) and weekly until day 56. The primary endpoint was the overall cumulative parasitological failure rate at day 56 after the start of treatment, with the hypothesis being that dihydroartemisinin-piperaquine was non-inferior compared to chloroquine (Delta = 5% difference in proportion of failures).
RESULTS: Of 2,182 individuals with positive blood films for P. vivax, 536 were enrolled in the trial. The day 28 cure rate was 100% in both treatment groups. Parasite clearance was more rapid with dihydroartemisinin-piperaquine than chloroquine. At day 56, there were more recurrent infections in the chloroquine arm (8.9%, 95% CI 6.0-13.1%) than the dihydroartemisinin-piperaquine arm (2.8%, 95% CI 1.4-5.8%), a difference in cumulative recurrence rate of 6.1% (2-sided 90%CI +2.6 to +9.7%). The log-rank test comparing the survival curves confirmed the superiority of dihydroartemisinin-piperaquine over chloroquine (p = 0.003). Multivariate analysis showed that a lower initial haemoglobin concentration was also independently associated with recurrence. Both regimens were well tolerated and no serious adverse events were reported.
CONCLUSIONS: Chloroquine remains an efficacious treatment for the treatment of vivax malaria in Afghanistan. In a setting where radical therapy cannot be administered, dihydroartemisinin-piperaquine provides additional benefit in terms of post-treatment prophylaxis, reducing the incidence of recurrence from 4-8 weeks after treatment
Publisher Correction: Synthesis of Saccharumoside-B analogue with potential of antiproliferative and pro-apoptotic activities (Scientific Reports, (2017), 7, 1, (8309), 10.1038/s41598-017-05832-w)
No full textIn the original version of this Article, Ghulam Md Ashraf was incorrectly affiliated with ‘Enzymoics and Novel Global Community Educational Foundation, Hebersham, NSW, Australia’. The correct affiliation is listed below. King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. Additionally, within the Supplementary Information file originally published with this Article, authors Vijaya Rao Pidugu, Mohammad A. Kamal, Ghulam Md Ashraf, Vadim V. Tarasov, Vladimir N. Chubarev, Sergey G. Klochkov, George E. Barreto and Sergey O. Bachurin were omitted. These errors have now been corrected in the PDF and HTML versions of the Article, and in the accompanying Supplementary material. © 2020, The Author(s).Universidad Autónoma de Chil
Application of Perpendicular Drought Index in the Drought Assessment: A Case Study in Ningxia Huizu Autonomous Region of China Using MODIS Data
No full textIn this paper, 1) atmospheric correction for nir and red channels of remote sensing imagery is carried out by 6S code, and nir-red spectral reflectance space is obtained using atmospheric and geometric corrected MODIS data; 2) perpendicular drought index (PDI) is calculated using MODIS data on the basis of the distribution characteristics of soil moisture in the nir-red spectral reflectance space; 3) sensitivity analysis and accuracy assessment of results contributed from upscaling of the PDI model to MODIS 500m spatial resolution is conducted; 4)finally, quantitative evaluation of drought condition of Ningxia, Northwestern China is carried out with PDI. Results show that satellite estimated drought values by PDI indicate significant negative correlation with 0 similar to 20cm averaged soil moisture obtained over the whole study area. Highest correlation is R(2)=0.53. It is evident from the results showing the spatial distribution of drought in. the Northwestern China that remote estimated drought information is highly accordant with field drought status.Geosciences, MultidisciplinaryRemote SensingImaging Science & Photographic TechnologyEICPCI-S(ISTP)
Hydraulic simulations to evaluate and predict design and operation of the Chashma Right Bank Canal
No full textIrrigation systems / Irrigation canals / Flow control / Velocity / Canal regulation techniques / Hydraulics / Simulation models / Design / Operations / Crop-based irrigation / Distributary canals / Water delivery / Policy / Protective irrigation / Water allocation / Water requirements / Sedimentation / Water distribution / Equity / Water conveyance / Pakistan / Chashma Right Bank Canal
Sub-canopy Soil Moisture Modeling in n-Dimensional Spectral Feature Space
No full textThis paper attempts to quantify soil moisture in various canopy cover conditions using n-dimensional spectral signatures, including land surface temperature, vegetation index, albedo, and others. First, the feature vector between the pixels and various moisture contents was indentified. Normalization of the varying distance from a user-defined initial state to any pixel location, and coefficients related with n-dimensional spectral feature space were calculated, assigning weights to each parameter. Then, a soil moisture index was developed using a linear combination of the first order polynomials. The Extended Fourier Amplitude Sensitivity Test (eFAsT) was used to calculate the relative variance contribution of model input parameters to the variance of soil moisture predictions. Results derived from satellite data including Enhanced Thematic Mapper Plus (ETM+) and the Moderate Resolution Imaging Spectroradiometer (worms) imagery demonstrated significant correlations between the index and soil moisture obtained for different ecosystems and vegetation cover. The best agreement, the coefficient of determination (R(2)), between the index and soil moisture were 0.58 and 0.65 for ETM+ and MODIS data, respectively. eFAST sensitivity analysis indicates that land surface temperature might be the most determinant factor in soil moisture estimation, then albedo, followed by NDVI.Geography, PhysicalGeosciences, MultidisciplinaryRemote SensingImaging Science & Photographic TechnologySCI(E)EI6ARTICLE2149-1567
Polymorphisms in Plasmodium vivax antifolate resistance markers in Afghanistan between 2007 and 2017
No full textBACKGROUND:Plasmodium vivax is the predominant Plasmodium species in Afghanistan. National guidelines recommend the combination of chloroquine and primaquine (CQ-PQ) for radical treatment of P. vivax malaria. Artesunate in combination with the antifolates sulfadoxine-pyrimethamine (SP) has been first-line treatment for uncomplicated falciparum malaria until 2016. Although SP has been the recommended treatment for falciparum and not vivax malaria, exposure of the P. vivax parasite population to SP might still have been quite extensive because of community based management of malaria. The change in the P. vivax antifolate resistance markers between 2007 and 2017 were investigated. METHODS:Dried blood spots were collected (n = 185) from confirmed P. vivax patients in five malaria-endemic areas of Afghanistan bordering Tajikistan, Turkmenistan and Pakistan, including Takhar, Faryab, Laghman, Nangarhar, and Kunar, in 2007, 2010 and 2017. Semi-nested PCR, RFLP and nucleotide sequencing were used to assess the pyrimethamine resistant related mutations in P. vivax dihydrofolate reductase (pvdhfr I13L, P33L, N50I, F57L, S58R, T61I, S93H, S117N, I173L) and the sulfonamide resistance related mutations in P. vivax dihydropteroate synthase (pvdhps A383G, A553G). RESULTS:In the 185 samples genotyped for pvdhfr and pvdhps mutations, 11 distinct haplotypes were observed, which evolved over time. In 2007, wild type pvdhfr and pvdhps were the most frequent haplotype in all study sites (81%, 80/99). However, in 2017, the frequency of the wild-type was reduced to 36%, (21/58; p value ≤ 0.001), with an increase in frequency of the double mutant pvdhfr and pvdhps haplotype S58RS117N (21%, 12/58), and the single pvdhfr mutant haplotype S117N (14%, 8/58). Triple and quadruple mutations were not found. In addition, pvdhfr mutations at position N50I (7%, 13/185) and the novel mutation S93H (6%, 11/185) were observed. Based on in silico protein modelling and molecular docking, the pvdhfr N50I mutation is expected to affect only moderately pyrimethamine binding, whereas the S93H mutation does not. CONCLUSIONS:In the course of ten years, there has been a strong increase in the frequency pyrimethamine resistance related mutations in pvdhfr in the P. vivax population in Afghanistan, although triple and quadruple mutations conferring high grade resistance were not observed. This suggests relatively low drug pressure from SP on the P. vivax parasite population in the study areas. The impact of two newly identified mutations in the pvdhfr gene on pyrimethamine resistance needs further investigation
The role of the accused in English and Islamic criminal justice
No full textThis thesis is a comparative study of the role of the accused in the systems of
English and Islamic criminal justice. It seeks to explore the underlying
relationship between the individual and the state through an historical, structural
and contextual analysis of their rules relating to questioning and of confessions.
The analysis of the English system covers the period 1800 to 1984, with
particular reference to developments during the nineteenth century when the
foundations for the modern English state were established. The analysis of the
Islamic system combines traditionally Islamic and modern methods, assessing the
"Islamisation" movement in Malaysia through a religico-structural understanding
of juristic opinion from the four main schools of Sunnite jurisprudence.
The thesis contributes to existing knowledge on a number of levels: first, it
questions and revises the "myth" of "progress" that has dominated observations
of the history of the English criminal justice system; second, it elucidates the
relationship between Islamic law in theory and the law that is applied and
proposed in its name in Muslim states; third, it provides an analytical framework
for drawing comparisons between the underlying values of the systems of English
and Islamic criminal justice.
While acknowledging fundamental differences in terms of outlook and
articulation, the author concludes there are important similarities expressed
through such notions as "suspect" in the English system and "kafir"I"fasiq" in the
Islamic. These act as intermediate constitutional categories to whom the state
owe less protection. But the author notes also that these similarities are not
observed necessarily in the "law" which is implemented or proposed in Muslim
states; exact correspondence depends upon the over-arching political structure
and the institution of Caliphate.
The thesis is divided into six chapters: chapter one sets out the conventional view
of the historical development of English criminal procedure and evidence;
chapter two subjects that to a critique and chapter three offers a revised thesis.
Chapter four, explores methods for interpreting and explaining Islam; chapter
five sets out rules relating to confessions and questioning according to the four
Sunni schools; chapter six puts them into "context" through an examination of
the "Islamisation" process in Malaysia
Implementation of Perpendicular Drought Index in Remote Sensing Supporting System
No full textThe main objective of this paper is the implementation of Perpendicular Drought Index (PDI), a simple, effective drought monitoring tool, in integrated remote sensing supporting system (IRSSS) for parameter retrieval and drought estimation. According to the COM rule, the IRSSS developed a particular interface in order to guarantee the users add new function module or file I/O driver by themselves. This paper introduces the implementation of PDI using C++ program language. There are four steps designed to complete the task. The general process and purpose of every step is explained and especially the method of finding soil point and memory management is introduced as the key technology. The paper also presents the results of evaluated drought situation of Ningxia Huizu Autonomous Region of China that indicates accordance with regional hydro-environmental data.Geosciences, MultidisciplinaryRemote SensingImaging Science & Photographic TechnologyEICPCI-S(ISTP)
Collected Papers (on Neutrosophics, Plithogenics, Hypersoft Set, Hypergraphs, and other topics), Volume X
No full textThis tenth volume of Collected Papers includes 86 papers in English and Spanish languages comprising 972 pages, written between 2014-2022 by the author alone or in collaboration with the following 105 co-authors (alphabetically ordered) from 26 countries: Abu Sufian, Ali Hassan, Ali Safaa Sadiq, Anirudha Ghosh, Assia Bakali, Atiqe Ur Rahman, Laura Bogdan, Willem K.M. Brauers, Erick González Caballero, Fausto Cavallaro, Gavrilă Calefariu, T. Chalapathi, Victor Christianto, Mihaela Colhon, Sergiu Boris Cononovici, Mamoni Dhar, Irfan Deli, Rebeca Escobar-Jara, Alexandru Gal, N. Gandotra, Sudipta Gayen, Vassilis C. Gerogiannis, Noel Batista Hernández, Hongnian Yu, Hongbo Wang, Mihaiela Iliescu, F. Nirmala Irudayam, Sripati Jha, Darjan Karabašević, T. Katican, Bakhtawar Ali Khan, Hina Khan, Volodymyr Krasnoholovets, R. Kiran Kumar, Manoranjan Kumar Singh, Ranjan Kumar, M. Lathamaheswari, Yasar Mahmood, Nivetha Martin, Adrian Mărgean, Octavian Melinte, Mingcong Deng, Marcel Migdalovici, Monika Moga, Sana Moin, Mohamed Abdel-Basset, Mohamed Elhoseny, Rehab Mohamed, Mohamed Talea, Kalyan Mondal, Muhammad Aslam, Muhammad Aslam Malik, Muhammad Ihsan, Muhammad Naveed Jafar, Muhammad Rayees Ahmad, Muhammad Saeed, Muhammad Saqlain, Muhammad Shabir, Mujahid Abbas, Mumtaz Ali, Radu I. Munteanu, Ghulam Murtaza, Munazza Naz, Tahsin Oner, Gabrijela Popović, Surapati Pramanik, R. Priya, S.P. Priyadharshini, Midha Qayyum, Quang-Thinh Bui, Shazia Rana, Akbara Rezaei, Jesús Estupiñán Ricardo, Rıdvan Sahin, Saeeda Mirvakili, Said Broumi, A. A. Salama, Flavius Aurelian Sârbu, Ganeshsree Selvachandran, Javid Shabbir, Shio Gai Quek, Son Hoang Le, Florentin Smarandache, Dragiša Stanujkić, S. Sudha, Taha Yasin Ozturk, Zaigham Tahir, The Houw Iong, Ayse Topal, Alptekin Ulutaș, Maikel Yelandi Leyva Vázquez, Rizha Vitania, Luige Vlădăreanu, Victor Vlădăreanu, Ștefan Vlăduțescu, J. Vimala, Dan Valeriu Voinea, Adem Yolcu, Yongfei Feng, Abd El-Nasser H. Zaied, Edmundas Kazimieras Zavadskas.
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