3,000 research outputs found
INDICES OF NEONATAL THYROID FUNCTION IN BRUNEI DARUSSALAM AND ITS APPLICATION TO NEWBORN SCREENING FOR CONGENTIAL HYPOTHROIDISM
No full textMaster'sMASTER OF SCIENC
The origin, functions, and nature of the tributary system in the Chou times
No full textIn this dissertation, the author, Ch’un-sik Yi, used the English version of his name, Choon S. Lee
Optimizing the Clinical Use of High-Sensitivity Troponin Assays: A Review
No full textIschemic heart diseases (IHDs) remain a global health concern. Many IHD cases go undiagnosed due to challenges in the initial diagnostic process, particularly in cases of acute myocardial infarction (AMI). High-sensitivity cardiac troponin (hs-cTn) assays have revolutionized myocardial injury assessment, but variations in diagnostic cut-off values and population differences have raised challenges. This review addresses essential laboratory and clinical considerations for hs-cTn assays. Laboratory guidelines discuss the importance of establishing standardized 99th-percentile upper reference limits (URLs) considering factors such as age, sex, health status, and analytical precision. The reference population should exclude individuals with comorbidities like diabetes and renal disease, and rigorous selection is crucial. Some clinical guidelines emphasize the significance of sex-specific URL limits while others do not. They highlight the use of serial troponin assays for AMI diagnosis. In addition, timely reporting of accurate hs-cTn results is essential for effective clinical use. This review aims to provide a clearer understanding among laboratory professionals and clinicians on how to optimize the use of hs-cTn assays in clinical settings in order to ensure accurate AMI diagnosis and thus improve patient care and outcomes
Emerging Role of Natriuretic Peptides in Diabetes Care: A Brief Review of Pertinent Recent Literature
No full textDiabetes markedly increases susceptibility to adverse cardiovascular events, including heart failure (HF), leading to heightened morbidity and mortality rates. Elevated levels of natriuretic peptides (NPs), notably B-type natriuretic peptide (BNP) and N-terminal-proBNP (NT-proBNP), correlate with cardiac structural and functional abnormalities, aiding in risk stratification and treatment strategies in individuals with diabetes. This article reviews the intricate relationship between diabetes and HF, emphasizing the role of NPs in risk assessment and guiding therapeutic strategies, particularly in individuals with type 2 diabetes mellitus (T2DM). We also explore the analytical and clinical considerations in the use of natriuretic peptide testing and the challenges and prospects of natriuretic-peptide-guided therapy in managing cardiovascular risk in patients with diabetes. We conclude with some reflections on future prospects for NPs
COMPLEXITIES OF 3-MANIFOLDS FROM TRIANGULATIONS, HEEGAARD SPLITTINGS AND SURGERY PRESENTATIONS
No full textWe study complexities of 3-manifolds defined from triangulations, Heegaard splittings, and surgery presentations. We show that these complexities are related by linear inequalities, by presenting explicit geometric constructions. We also show that our linear inequalities are asymptotically optimal. Our results are used in another paper of the author to estimate Cheeger-Gromov L-2 rho-invariants in terms of geometric group theoretic and knot theoretic data.110sciescopu
Trend towards multiple authorship in occupational medicine journals
No full textAbstract Background There is an established trend towards an increasing number of authors per article in prestigious journals for medicine and health sciences. It is uncertain whether a similar trend occurs to the same extent in journals for specific medical specialties. Methods Journals focusing on occupational medicine were selected for analysis with regard to single or multiple-authorship per peer-reviewed paper. Data were collected from PubMed for publications between 1970 and 2007. These were analysed to calculate the average number of authors per multiple-author article per year and the percentage of single-author articles per year. The slope and average of these journals were then compared with that of previously studied non-occupational medicine journals. Results The results confirm a trend towards a linear increase in the average number of authors per article and a linear decrease in the percentage of single-author articles. The slope for the average number of authors for multiple-author articles was significantly higher in the Journal of Occupational and Environmental Medicine than in the other occupational medicine journals. Computational analysis of all articles published showed that Occupational Medicine (Oxford) had a significantly higher percentage of single-author articles than the other occupational medicine journals as well as major journals previously studied. Conclusion The same trend towards multiple authorship can be observed in medical specialty journals as in major journals for medicine and health sciences. There is a direct relationship between occupational journals with higher impact factors and a higher average number of authors per article in those journals.</p
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