534 research outputs found
PandA
No full textData and code for C.M. Aldwin, S. Y. Choun, & Avron Spiro, The Coping, Appraisal and Resilience in Aging (CARA) model: Longitudinal findings from the VA Normative Aging Study. Psychology and Aging
Critique of Cognitive Measures in the Health Retirement Study (HRS) and the Asset and Health Dynamics among the Oldest Old (AHEAD) Study
No full texthttp://deepblue.lib.umich.edu/bitstream/2027.42/196307/1/Lachman&Spiro- HRScognitive.pdfSEL
Impact of body mass index on mortality in the veterans administration normative aging study
No full textHigh body mass index (BMI) has been found to be associated with a multitude of health issues and its longitudinal effect on mortality needs to be further understood due to increasing rates of obesity. The relationship between BMI and mortality is a key public health concern due to the rise in obesity prevalence and advancing knowledge of the impact of BMI on all aspects of health.
In order to expand and further contribute to the understanding of the long-term impact of BMI on mortality, we utilized prospective, longitudinal data from the Veterans Affairs (VA) Normative Aging Study (NAS) to assess the relationship between BMI and 40-year all-cause and cause-specific mortality in men. Cox regression was used to evaluate the relationship between BMI and all-cause and cause-specific (cancer, congenital heart disease (CHD), stroke) mortality.
Of the 1,680 men included in this study, the majority were White (96.7%), born between 1920–1929, were between ages 50–59 years, married, completed some college, identified as an occasional drinker and a current smoker, and worked in a “white-collar” job. This study did not identify any men who had an underweight BMI. 594 men had normal BMI, 910 men were overweight, and 176 men were obese.
After adjusting for confounders, compared to men with normal BMI, overweight men had higher risk for CHD mortality (HR=1.33, 95% CI, 0.95–1.86), lower risk for all-cause and stroke mortality (HR=0.98, 95% CI, 0.87–1.11, HR=0.88, 95% CI, 0.53–1.45, respectively), and no difference in risk for cancer mortality (HR=1.00, 95% CI, 0.82–1.23). Obese men had higher risk for all-cause and stroke mortality (HR=1.19, 95% CI, 0.98–1.45, HR=1.26, 95% CI, 0.57–2.79, respectively) and lower risk for CHD and cancer mortality (HR=0.87, 95% CI, 0.48–1.58, HR=0.95, 95% CI, 0.68–1.33, respectively).
In conclusion, this study found that men categorized as obese had an increased risk of all-cause and stroke mortality, and men categorized as overweight had an increased risk of CHD mortality, compared to those with normal BMI. However, due to all confidence intervals crossing 1.00, there is a suggestion that BMI had an effect on mortality in this sample. These results are limited by selection bias during the NAS screening process which selected for healthy men. This may have skewed our results toward the null, potentially diminishing the association between BMI and mortality
An existence theorem for stationary discs in almost complex manifolds
No full textAbstractAn existence theorem for stationary discs of strongly pseudo-convex domains in almost complex manifolds is proved. More precisely, it is shown that, for all points of a suitable neighborhood of the boundary and for any vector belonging to certain open subsets of the tangent spaces, there exists a unique stationary disc passing through that point and tangent to the given vector. This result gives a generalization of a theorem of B. Coupet, H. Gaussier and the second author, originally proved only for almost complex structures which are small deformations of an integrable one
How the Ji’kmaqn Came to Spiro: Possible Additions to the Inventory of Sound-Making Instruments Depicted in the Spiro Engravings
No full textWhile doing research on turtle shell rattles the author stumbled onto a photograph of a rare and unusual idiophone whose exact likeness appears twice in one of the engraved shell images from Spiro. This paper describes the instrument and the Spiro image and discusses how an instrument currently found only in the Maritime Provinces of Canada may have come to be portrayed on a marine shell cup found at Spiro
Polycyclic Spiro Lignans and Biphenyl Tetrahydrofuranone Lignans from Gymnotheca involucrata
No full textFour rare polycyclic spiro lignans (1-4) and four new biphenyl tetrahydrofuranone lignans (5-8) were isolated from the whole plant of Gymnotheca involucrata. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis and the absolute configuration of 1 was confirmed by single crystal X-ray diffraction. Bioassay results showed that compounds 2 and 6 exhibited weak antifungal activity against Uromyces viciae-fabae at 100 ppm in leaf-disc assays, while compound 3 demonstrated moderate insecticidal activity against Diabrotica balteata at 500 ppm in an artificial diet assay
Synthesis of spiro[4.4]nonane-containing functional organic molecules
No full textSpiro[4.4]nonane features are an important scaffold in many applications such as enantioenriched ligands, functional materials, natural products, and polymers. Excited by the prospect of the spiro[4.4]nonane scaffold, its structural intricacy still appears challenging in chemical synthesis. Many functional organic molecules possessing spiro[4.4]nonane scaffold(s) have recently been reported and synthesized. We provide a Minireview highlighting such advancements and discuss the future opportunities of spiro[4.4]nonane scaffolds in organic chemistry. Representative examples from 2019 to 2024 are discussed. © 2024 The Author
NAS/DLS Publications 1965-2025
No full textPublication list of VA Normative Aging Study, Dental Longitudinal Study, and "SPANCO" study (1959-1967)
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