78 research outputs found
Maternal dietary ALA prevents atherogenic lipid disarray in the offspring via fetal gene programming
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Application of the Colorless Carotenoids, Phytoene, and Phytofluene in Cosmetics, Wellness, Nutrition, and Therapeutics
No full textApplication of the Colorless Carotenoids, Phytoene, and Phytofluene in Cosmetics, Wellness, Nutrition, and Therapeutics
No full textThe Carotenoid Composition of Larvae Feed Is Reflected in Adult House Fly (<i>Musca domestica</i>) Body
No full textCarotenoids are common and diverse organic compounds with various functional roles in animals. Except for certain aphids, mites, and gall midges, all animals only acquire necessary carotenoids through their diet. The house fly (Musca domestica) is a cosmopolitan pest insect that populates diverse habitats. Its larvae feed on organic substrates that may vary in carotenoid composition according to their specific content. We hypothesized that the carotenoid composition in the adult house fly’s body would reflect the carotenoid composition in the larval feed. House fly larvae were reared on diets that differed in carotenoid composition. HPLC analysis of the emerging adult flies indicate that the carotenoid composition of adult house flies is related, but not identical, to the carotenoid composition in its natal substrate. These findings may be developed to help identify potential sources of house fly infestations. Also, it is recommended that rearing substrates of house fly larvae, used for animal feed, should be carefully considered
Organ Loci of Catabolism of Short Truncations of ApoB
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Abstract
Truncations of apolipoprotein (apo) B shorter than 3200 amino acids (3200/4536=apoB-70) do not possess the LDL receptor–recognition domain and are not recognized by altered cells with normally functioning LDL receptors. To ascertain which organs remove such truncated apoB–containing particles, we isolated apoB-31–, apoB-38.9–, and apoB-43.7–containing particles from plasmas of familial hypobetalipoproteinemia heterozygous humans by a combination of sequential ultracentrifugation and preparative electrophoresis. Particles with labeled
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I-dilactitol tyramine (I-DLT), were injected into New Zealand White rabbits, along with I-DLT–apoB-100–containing LDLs, and the decay of
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I-TCA–precipitated counts was followed over 24 hours. At the end of 24 hours, rabbits were anesthetized and their bodies perfused. Organs were removed and homogenized, and TCA-precipitable counts determined. Fractional catabolic rates of apoB truncation particles were two to five times greater than those of apoB-100 LDLs. ApoB truncations accumulated in adrenals at one fifth the rates of apoB-100 LDL, compatible with the functional absences of LDL receptor–recognition domains in truncated apoBs. The major organ of uptake for apoB-100-LDLs was the liver, whereas truncation particles were readily removed by the kidney (kidney: liver uptake ratios were 0.10 to 0.30 for apoB-100 LDLs and 1.03 to 3.77 for truncations). Spleens accumulated little of either apoB-100 or truncation particles, suggesting particles were not “damaged” or aggregated. Thus, the absence of >56% of the carboxyl end of apoB-100 increases the plasma clearance and redirects the organ uptake of the apoB truncation–containing lipoproteins from liver to kidney.
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A Carotenoid Algal Preparation Containing Phytoene and Phytofluene Inhibited LDL Oxidation In Vitro
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