1,721,314 research outputs found
Austin Smith, Library Expansion
Full text linkAustin Smith, an architecture student, is shown with his model of proposed library expansion.https://scholarsjunction.msstate.edu/ua-photo-collection/4562/thumbnail.jp
William McCain, Austin Smith, John Frye, Library Expansion
Full text linkDean William McCain and students, Austin Smith and John Frye, are shown in the Stennis Lobby of the libraryhttps://scholarsjunction.msstate.edu/ua-photo-collection/4570/thumbnail.jp
Farewell celebration for Murray Austin-Smith, Graphic Designer at Murdoch University
No full textFarewell celebration for Murray Austin-Smith, Graphic Designer at Murdoch University.
The complete set of 4 negatives is available at the Murdoch University Library.
These images are part of the History of Murdoch University Collection
C-0755: 444 South 200 West, Smithfield, Utah, Austin Smith residence. Sec 33 T 13N R 1 E. Built 1932
No full textC-0755: 444 South 200 West, Smithfield, Utah, Austin Smith residence. Sec 33 T 13N R 1 E. Built 193
Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor
Full text linkSelf-renewal of pluripotent mouse embryonic stem (ES) cells is sustained by the cytokine leukaemia inhibitory factor (LIF) acting through the transcription factor Stat3. Several targets of Stat3 have previously been identified, most notably the reprogramming factor Klf4. However, such factors are neither required nor sufficient for the potent effect of LIF. We took advantage of Stat3 null ES cells to confirm that Stat3 mediates the self-renewal response to LIF. Through comparative transcriptome analysis intersected with genome location data, we arrived at a set of candidate transcription factor effectors. Among these, Tfcp2l1 (also known as Crtr-1) was most abundant. Constitutive expression of Tfcp2l1 at levels similar to those induced by LIF effectively substituted for LIF or Stat3 in sustaining clonal self-renewal and pluripotency. Conversely, knockdown of Tfcp2l1 profoundly compromised responsiveness to LIF. We further found that Tfcp2l1 is both necessary and sufficient to direct molecular reprogramming of post-implantation epiblast stem cells to naïve pluripotency. These results establish Tfcp2l1 as the principal bridge between LIF/Stat3 input and the transcription factor core of naïve pluripotency
R. M. Scholtes, James Brown, Austin Smith, Dean William McCain, Mike Fazio, Library Expansion
Full text linkDr. R. M. Scholtes (Continuing Education staff), James Brown (student), Austin Smith (student), Dean William McCain (Architecture, back to camera), and Mike Fazio (architecture staff) are pictured in the Stennis Lobby of the Library during a showing of library expansion modelshttps://scholarsjunction.msstate.edu/ua-photo-collection/4573/thumbnail.jp
Barriers to Mixed Use, Douglas Wheeler Associates with Ann Flint Associates Austin-Smith
Full text linkBarriers to Mixed Use, Douglas Wheeler Associates with Ann Flint Associates Austin-Smith: Lord Edinburgh College of Art, 2009, Scottish Government Social Research Commissioned Report, Communities Analytical Services, part of the Housing and Regeneration Directorate of the Scottish Government on behalf of the Commissioned Report submitted to the Directorate for the Built Environment
Barriers to Mixed Use, Douglas Wheeler Associates with Ann Flint Associates Austin-Smith
Full text linkBarriers to Mixed Use, Douglas Wheeler Associates with Ann Flint Associates Austin-Smith: Lord Edinburgh College of Art, 2009, Scottish Government Social Research Commissioned Report, Communities Analytical Services, part of the Housing and Regeneration Directorate of the Scottish Government on behalf of the Commissioned Report submitted to the Directorate for the Built Environment
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