160 research outputs found
Construction of Fedholm Representations and a Modification of the Higson-Roe Corona. In "Russian Journal of Mathematical Physics".
No full textThe Fredholm representation theory is well adapted to the construction of homotopy invariants of non-simply-connected manifolds by means of the generalized Hirzebruch formula [(M)] = hL(M) chA f, [M]i ∈ K0 A(pt) ⊗ Q, where A = C[] is the C-algebra of the group , = 1(M). The bundle ∈ K0
A(B) is the canonical A-bundle generated by the natural representation −→ A.
Recently, the first author constructed a natural family of Fredholm representations that lead to a symmetric vector bundle on the completion of the fundamental group with a modification of the Higson–Roe corona, provided that the completion is a closed manifold.
In the present paper, a homology version of symmetry is discussed for the case in which the completion, with a modification of the Higson–Roe corona, is a manifold with boundary. The results were developed during the visit of the first author to Ancona on March, 2007.
The last version is supplemented by details considering the case of manifolds with boundary
In Vivo Mapping of Hydrogen Peroxide and Oxidized Glutathione Reveals Chemical and Regional Specificity of Redox Homeostasis
No full textSummaryThe glutathione redox couple (GSH/GSSG) and hydrogen peroxide (H2O2) are central to redox homeostasis and redox signaling, yet their distribution within an organism is difficult to measure. Using genetically encoded redox probes in Drosophila, we establish quantitative in vivo mapping of the glutathione redox potential (EGSH) and H2O2 in defined subcellular compartments (cytosol and mitochondria) across the whole animal during development and aging. A chemical strategy to trap the in vivo redox state of the transgenic biosensor during specimen dissection and fixation expands the scope of fluorescence redox imaging to include the deep tissues of the adult fly. We find that development and aging are associated with redox changes that are distinctly redox couple-, subcellular compartment-, and tissue-specific. Midgut enterocytes are identified as prominent sites of age-dependent cytosolic H2O2 accumulation. A longer life span correlated with increased formation of oxidants in the gut, rather than a decrease
Privileged Signaling for Brain Growth
No full textWhen developing animals encounter nutrient restriction, most tissues stop growing. Some vital tissues, however, such as the brain, continue to grow. Now, Cheng et al. (2011) identify Alk as the kinase that allows the Drosophila brain to continue growing during nutrient restriction by bypassing the requirements for insulin receptor and TOR activation
Growth regulation by the TOR pathway
No full textSéminaire FSER organisé par Michael Hall (Biozentrum, Bâle) et David M. Sabatini (Whitehead Institute, Cambridge, Massachussets) du 4 au 9 juin 2012 Participants John Blenis, Anne Brunet, Claudio De Virgilio, Eyal Gottlieb, Kun-Liang Wang, Michael N. Hall, D. Grahame Hardie, Marc W. Kirschner, Pierre Léopold, Alison Lloyd, Brendan D. Manning, Christian Meyer, Linda Partridge, Mario Pende, L. Bryan Ray (editor), David M. Sabatini, Reuben Shaw, Aurelio A. Teleman, Jeremy Thorner, Anders Zetterb..
Recommended from our members
Open questions: completing the parts list and finding the integrating signals
No full textOne of the great revelations of post-genomic biology has been the extent to which essential functions and mechanisms are conserved across vast phylogenetic distances. Because of this, we can look to the fruit fly for answers to pressing open questions on the unknown functions of genes and the mechanisms of their physiological integration.Version of Recor
miR-200 De-FOGs Insulin Signaling
No full textInsulin signaling is a key regulator of metabolism and tissue growth in animals. Recent work in Cell (Hyun et al., 2009) defines two conserved components of the insulin pathway: a microRNA and the protein USH/FOG2
A study of the control of tissue growth and patterning in Drosophila melanogaster
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Faculty Opinions recommendation of Adipose-derived circulating miRNAs regulate gene expression in other tissues.
No full text
- …
