29 research outputs found
Ruthenium-Catalyzed C–H Bond Arylations of Arenes Bearing Removable Directing Groups via Six-Membered Ruthenacycles
No full textRuthenium-catalyzed direct arylations of phenols bearing removable directing groups were accomplished through carboxylate assistance via six-membered ruthenacycles as key intermediates.CaSuS PhD program; Erasmus Mundus program; Georg-August-Universit
ChemInform Abstract: Ruthenium‐Catalyzed C—H Bond Arylations of Arenes Bearing Removable Directing Groups via Six‐Membered Ruthenacycles.
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Diversity oriented design of various hydrazides and their in vitro evaluation against Mycobacterium tuberculosis H37Rv strains
No full textControl and prevention of tuberculosis is a major challenge, as one-third of the world’s population is infected with Mycobacterium tuberculosis. The resurgence of tuberculosis and the emergence of multidrug-resistance strains of mycobacteria, necessitate the search for new class of antimycobacterial agents. As a part of investigation of new antitubercular agents in this laboratory, we describe the syntheses of various hydrazides of comarins, quinolones and pyrroles and screening against M. tuberculosis (Mtb) H37Rv by using rifampin as a standard drug. Among the designed molecules, the most prominent compounds 2a–g, 4a and 9a showed >90% GI at MIC <6.25 μg/mL. Finally, these studies suggests that compounds 2a–g, 4a and 9a may serve as promising lead scaffolds for further generation of new anti-TB agents
Continuous Flow and Microwave-Assisted Vorbrüggen Glycosylations: Historical Perspective to High-Throughput Strategies
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Synthetic Approach towards Potential Bioactive Heterocycles and Other Compounds
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Subtle Mitsunobu couplings under super-heating: the role of high-throughput continuous flow and microwave strategies
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