70 research outputs found
Copper-Catalyzed Simultaneous Activation of C–H and N–H Bonds: Three-Component One-Pot Cascade Synthesis of Multisubstituted Imidazoles
No full textA copper-catalyzed expedient, practical, and straightforward approach for the one-pot three-component modular synthesis of multisubstituted imidazoles has been described by using arylacetic acids, N-arylbenzamidines, and nitroalkanes. The reaction involves simultaneous activation of C–H and N–H bonds of arylacetic acids and N-arylbenzamidines, respectively. The use of inexpensive copper sulfate as a catalyst, readily available starting materials, and Celite-free workup makes this protocol economically viable. Multisubstituted imidazoles were obtained in moderate to good yields with significant functional group tolerance and high regioselectivity
Bipolar Host Materials: A Chemical Approach for Highly Efficient Electrophosphorescent Devices
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An Efficient Synthesis of 1,2,4-Trisubstituted Imidazoles from Arylacetic Acids and N -Arylbenzamidines via Simultaneous C-H and N-H Bond Activation
No full textA convenient and effective FeCl3 catalyzed one-pot three
component protocol for the synthesis of 1,2,4-trisubstituted
imidazoles from arylacetic acids, N-arylbenzamidines and nitromethane
via simultaneous CH and NH bond activation has
been developed. The reaction involves CH activation of
arylacetic acid to form aromatic aldehyde which on condensation
with N-arylbenzamidine gives azadiene. Nitromethane on
Michael addition with azadiene produces ring annulated
intermediate which upon subsequent cyclization-elimination
sequence offers imidazole. The process utilizes readily available
arylacetic acids and inexpensive catalyst. This user friendly
protocol provided 1,2,4-trisubstituted imidazoles in moderate
to good yields with high functional group tolerance and ample
substrate scope
Tandem Protocol for the Synthesis of 3-Acyl Benzothiadiazine 1,1-Dioxides
No full textA metal-free and efficient tandem synthesis of 3-acyl 3,4-dihydro-2H-1,2,4-benzothiadiazine-1,1-dioxides and 3-acyl-2H-1,2,4-benzothiadiazine-1,1-dioxides has been developed via C−H functionalization of ethynylarenes and ethenylarenes followed by condensation with 2-aminobenzenesulfonamide. The reaction involves the formation of arylglyoxal as an intermediate from multiform substrates through Kornblum oxidation in the presence of iodine and DMSO. Use of simple and readily available starting materials, inexpensive reagent, broad substrate scope and a very simple operation are noteworthy features of this protocol. This method provides an easy access to pharmaceutically important 3-acyl-1,2,4-benzothiadiazine-1,1-dioxides in good yields
Carbazole-benzimidazole hybrid bipolar host materials for highly efficient green and blue phosphorescent OLEDs
No full textChemInform Abstract: Catalyst Free One‐Pot Three‐Component Synthesis of 2‐Amino‐4H‐chromene Derivatives in Aqueous Deep Eutectic Mixture at Room Temperature.
No full textChemInform Abstract: Direct Allylation of Alcohols Using Allyltrimethylsilane and a Move Towards an Economical and Ecological Protocol for C—C Bond Formation
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