559 research outputs found
Antimicrobial, cytotoxic, and insulin-releasing activities of the amphibian host-defense peptide ocellatin-3N and its L-lysine-substituted analogs
No full textThe host-defense peptide ocellatin-3N (GIFDVLKNLAKGVITSLAS.NH2), first isolated from the Caribbean frog Leptodactylus nesiotus, inhibited growth of clinically relevant Gram-positive and Gram-negative bacteria as well as a strain of the major emerging yeast pathogen Candida parapsilosis. Increasing cationicity while maintaining amphipathicity by the substitution Asp(4)-> Lys increased potency against the microorganisms by between 4- and 16-fold (MIC <= 3 mu M) compared with the naturally occurring peptide. The substitution Ala(18)-> Lys and the double substitution Asp(4)-> Lys and Ala(18)-> Lys had less effects on potency. The [D4K] analog also showed 2.5- to 4-fold greater cytotoxic potency against non-small-cell lung adenocarcinoma A549 cells, breast adenocarcinoma MDA-MB-231 cells, and colorectal adenocarcinoma HT-29 cells (LC50 values in the range of 12-20 mu M) compared with ocellatin-3N but was less hemolytic to mouse erythrocytes. However, the peptide showed no selectivity for tumor-derived cells [LC50 = 20 mu M for human umbilical vein endothelial cells (HUVECs)]. Ocellatin-3N and [D4K]ocellatin-3N stimulated the release of insulin from BRIN-BD11 clonal beta-cells at concentrations >= 1 nM, and [A18K]ocellatin-3N, at concentrations >= 0.1 nM. No peptide stimulated the release of lactate dehydrogenase at concentrations up to 3 mu M, indicating that plasma membrane integrity had been preserved. The three peptides produced an increase in intracellular [Ca2+] in BRIN-BD11 cells when incubated at a concentration of 1 mu M. In view of its high insulinotropic potency and relatively low hemolytic activity, the [A18K] ocellatin analog may represent a template for the design of agents with therapeutic potential for the treatment of patients with type 2 diabetes
Samir Amin : intellectuel organique au service de l'emancipation du sud
No full textThis book on Professor Samir Amin retraces his family origins, intellectual itinerary, political struggles as well as his experience in economic policy formulation in Egypt, Mali and many other countries. The fundamentals which shaped Samir Amin's thinking, directed his life-long work and influenced his action spawned from his early discovery in high school of Marxism and Historical Materialism, used as a scientific analysis of the history of human societies. This book also highlights Samir Amin's invaluable contribution to the struggle against capitalism through his indefatigable fight to deconstruct the concepts that are used to disguise the true face of historical capitalism, which is nothing but an unabashed pursuit for accumulation and dispossession of dominated countries and peoples. Through a series of interviews with Samir Amin, the author unravels the poignant and great ideas which have been at the heart of his intellectual and political fight for the last half century. The author also provides a selection of texts which includes an exhaustive bibliography, with all published writings of Samir Amin in French. This rich work is meant for a large readership - students, researchers, teachers, political leaders and citizens who are interested in the phenomenon of globalisation and its impact on the so-called 'under-developed countries
Interview with Samir Gharib
No full textلقاء مع المؤلف المصري سمير غريب حول كتاب "راية الخيال" للكاتب إبراهيم غريب وهو كتاب عن الحركة السريالية في العالم ويربط فيه المؤلف بين التاريخ والأدب والفنون الجميلة وعلم النفس والفكر والسينما. أجرى هذا اللقاء حسن شمس الدين.An interview with Egyptian author Samir Gharib about the book The Flag of Imagination by Egyptian writer Ibrahim Gharib. The book is about the surrealist movement around the world and adopts a mix of approaches and influences from history, literature, fine arts, psychology, philosophy, and cinema. Interview conducted by Hassan Shams El Din
Conformational analysis of the host-defense peptides pseudhymenochirin-1pb and -2pa and design of analogues with insulin-releasing activities and reduced toxicities
No full textPseudhymenochirin-1Pb (Ps-1Pb; IKIPSFFRNILKKVGKEAVSLIAGALKQS) and pseudhymenochirin-2Pa (Ps-2Pa; GIFPIFAKLLGKVIKVASSLISKGRTE) are amphibian peptides with broad spectrum antimicrobial activities and cytotoxicity against mammalian cells. In the membrane-mimetic solvent 50% (v/v) trifluoroethanol-H2O, both peptides adopt a well-defined α-helical conformation that extends over almost all the sequence and incorporates a flexible bend. Both peptides significantly (p 100 μM) but retain broad-spectrum antimicrobial activity and remain cytotoxic to a range of human tumor cell lines, albeit with lower potency than the naturally occurring peptides. These analogues show potential for development into agents for type 2 diabetes therap
R12. Preparation and characterization of ligand attached new 8-aminoquinoline derivative loaded nanostructured lipid carriers for liver targeting
No full textCorresponding author (Pharmaceutics and Drug delivery): Samir Senapati, [email protected]://egrove.olemiss.edu/pharm_annual_posters/1011/thumbnail.jp
Interview with Samir Abdel Baqi
No full textمقابلة مع الشاعر الغنائي وكاتب المسرح وأدب الأطفال المصري، سمير عبد الباقى، يناقش فيها أعماله الشعرية مثل "كلام من القلب،" و"أغنيات الإيدين السمرة." ويقرأ بصوته من أشعاره، كما يتحدث عن بداياته في كتابة الشعر العامي، وتأثره بأستاذه الشيخ علي سعود، والشاعر صلاح جاهين. قام بالمقابلة حسن شمس الدين.An interview with Egyptian lyric poet, playwright, and author of children's literature, Samir Abdel-Baqi, in which he discusses his poet work such as "speech From The Heart," and recites some of his poems. He also discusses how he started writing colloquial poetry, and of being influenced by his teacher, Sheikh Ali Saud, and the poet Salah Jaheen. The interview was conducted by Hassan Shams Al-Din
Interview with Samir Abdel Baqi
No full textمقابلة مع الشاعر الغنائي وكاتب المسرح وأدب الأطفال المصري، سمير عبد الباقى، يناقش فيها تجربته لكتابة أدب الطفل والإنفتاح والبراءة التي تكتنف تلك التجربة. ويذكر من قصصه للأطفال قصة "حباية قمح،" التي قرأها بصوته، كما يتحدث عن أعماله بمسرح العرائس ومنها "قرص عسل،" و"أرنب فوق العادة." وأخيراً، يناقش كتاباته للمسرح القومي مثل مسرحيات "مقالب عطيات،" و"الجميزة." قام بالمقابلة حسن شمس الدين.An interview with Egyptian lyric poet, playwright, and author of children's literature, Samir Abdel-Baqi, in which he discusses his experience of writing children's literature and the openness and innocence that accompany it. He also discusses some of his works, such as “Grain of Wheat,” which he reads parts of it in his own voice, and mentions some of his work in the puppet theater, including “Honeycomb” and “The Extraordinary Rabbit.” Finally, he talks about his work for the National Theater, such as the plays "Attiyat's Pranks," and "Gemmayzeh." The interview was conducted by Hassan Shams Al-Din
Erratum for “Protective role of allicin (diallyl thiosulfinate) on cell surface glycoconjugate moieties in 7,12- dimethylbenz(a) anthracene-induced oral carcinogenesis”
No full textJin et al Trop J Pharm Res 2017, 16(8): 1797-1804 http://dx.doi.org/10.4314/tjpr.v16i8.7The name and address of the second author, Samir Qiblawi, were inadvertently omitted in earlier published article.Citation: Dhanarasu S, Qiblawi S. Protective role of allicin (diallyl thiosulfinate) on cell surface glycoconjugate moieties in 7,12-dimethylbenz(a) anthracene-induced oral carcinogenesis. Trop J Pharm Res 2017; 16(8):1797-1804 Erratum: 2017; 16(9):2055 http://dx.doi.org/10.4314/tjpr.v16i9.
Managing today's news media : audience first /
No full textThe business of journalism is in the midst of massive change. Managing Today's News Media: Audience First offers practical solutions on how to cope with and adapt to the evolving media landscape. News media experts Samir Husni, Debora Halpern Wenger, and Hank Price introduce a forward-looking framework for understanding why change is occurring and what it means to the business of journalism. Central to this new paradigm is a focus on the audience. The authors introduce "The 4Cs Strategy" to describe how customers, control, choice, and change are all part of a strategy for successful media organizations. Every chapter in the book relates to one or more of these four key principles: * Customer - Each platform must offer a unique experience to the customer. ...Includes bibliographical references (pages 203-210) and index.The business of journalism is in the midst of massive change. Managing Today's News Media: Audience First offers practical solutions on how to cope with and adapt to the evolving media landscape. News media experts Samir Husni, Debora Halpern Wenger, and Hank Price introduce a forward-looking framework for understanding why change is occurring and what it means to the business of journalism. Central to this new paradigm is a focus on the audience. The authors introduce "The 4Cs Strategy" to describe how customers, control, choice, and change are all part of a strategy for successful media organizations. Every chapter in the book relates to one or more of these four key principles: * Customer - Each platform must offer a unique experience to the customer. ...Description based on MARC record for print version
Carnosol, a natural polyphenol, inhibits migration, metastasis, and tumor growth of breast cancer via a ROS-dependent proteasome degradation of STAT3
No full textWe have previously demonstrated that carnosol, a naturally occurring diterpene, inhibited in vitro cell viability and colony growth, as well as induced cell cycle arrest, autophagy and apoptosis in human triple negative breast cancer (TNBC) cells. In the present study, we evaluated the ability of carnosol to inhibit tumor growth and metastasis in vivo. We found that non-cytotoxic concentrations of carnosol inhibited the migration and invasion of MDA-MB-231 cells in wound healing and matrigel invasion assays. Furthermore, gelatin zymography, ELISA, and RT-PCR assays revealed that carnosol inhibited the activity and downregulation the expression of MMP-9. Mechanistically, we demonstrated that carnosol suppressed the activation of STAT3 signaling pathway through a ROS-dependent targeting of STAT3 to proteasome-degradation in breast cancer cells (MDA-MB-231, Hs578T, MCF-7, and T47D). We show that blockade of proteasome activity, by MG-132 and bortezomib, or ROS accumulation, by N-acetylcysteine (NAC), restored the level of STAT3 protein. In addition, using chick embryo tumor growth assay, we showed that carnosol significantly and markedly suppressed tumor growth and metastasis of breast cancer xenografts. To the best of our knowledge, this is the first report which shows that carnosol specifically targets signal transducer and activator of transcription 3 (STAT3) for proteasome degradation in breast cancer. Our study further provide evidence that carnosol may represent a promising therapeutic candidate that canmodulate breast cancer growth and metastasis. © 2019 Alsamri, El Hasasna, Al Dhaheri, Eid, Attoub and Iratni
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