158 research outputs found

    True precocious puberty associated with phenylketonuria

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    We studied a girl with phenylketonuria who demonstrated signs of precocious puberty. At the age of 7.5 years she had premature telarche. Her height age was 7-9/12 years and her bone age was 9 years. Gonadotropin responses to LHRH administration were consistent with central precocious puberty. Elevated serum phenylalanine levels in this patient, due to poor compliance with the phenylalanine restricted diet, may be related to the early onset of puberty. © 1994 Freund Publishing House Ltd

    Erratum To ‘Response To Early Coenzyme Q10 Supplementation Is Not Sustained In Coq10 Deficiency Caused By Coq2 Mutation’ [Pediatric Neurology 88 (2018) 71–74](S0887899418303795)(10.1016/J.Pediatrneurol.2018.07.008)

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    The publisher regrets to inform that the affiliation of the author Fehime Eroglu, Fatih Ozaltin, Rezan Topaloglu and Ali Düzova has been incorrectly published earlier. The publisher would like to apologise for any inconvenience caused. The affiliations should be corrected as follows: Fehime K. Eroglu, MD a , Fatih Ozaltin, MD a,b , Nazli Gönç, MD c , Hülya Nalçacıoğlu, MD d , Z. Birsin Özçakar, MD e , Dilek Yalnızoğlu, MD f , Şafak Güçer, MD g , Diclehan Orhan, MD g , Fatma Tuba Eminoğlu, MD h , Rahşan Göçmen, MD i , Ayfer Alikaşifoğlu, MD c , Rezan Topaloğlu, MD a , Ali Düzova, MD a, * a Division of Pediatric Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey b Nephrogenetics Laboratory, Division of Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey c Division of Pediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey d Division of Pediatric Nephrology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey e Division of Pediatric Nephrology, Ankara University Faculty of Medicine, Ankara, Turkey f Division of Pediatric Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey g Department of Pathology, Hacettepe University Faculty of Medicine, Ankara, Turkey h Division of Pediatric Metabolism, Ankara University Faculty of Medicine, Ankara, Turkey i Department of Radiology, Hacettepe University Faculty of Medicine, Ankara, Turkey © 2018 Elsevier Inc.Scopu

    Measurement of cognitive dynamics during video watching through event-related potentials (ERPs) and oscillations (EROs)

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    Event-related potentials (ERPs) and oscillations (EROs) are reliable measures of cognition, but they require time-locked electroencephalographic (EEG) data to repetitive triggers that are not available in continuous sensory input streams. However, such real-life-like stimulation by videos or virtual-reality environments may serve as powerful means of creating specific cognitive or affective states and help to investigate dysfunctions in psychiatric and neurological disorders more efficiently. This study aims to develop a method to generate ERPs and EROs during watching videos. Repeated luminance changes were introduced on short video segments, while EEGs of 10 subjects were recorded. The ERP/EROs time-locked to these distortions were analyzed in time and time-frequency domains and tested for their cognitive significance through a long term memory test that included frames from the watched videos. For each subject, ERPs and EROs corresponding to video segments of recalled images with 25% shortest and 25% longest reaction times were compared. ERPs produced by transient luminance changes displayed statistically significant fluctuations both in time and time-frequency domains. Statistical analyses showed that a positivity around 450 ms, a negativity around 500 ms and delta and theta EROs correlated with memory performance. Few studies mixed video streams with simultaneous ERP/ERO experiments with discrete task-relevant or passively presented auditory or somatosensory stimuli, while the present study, by obtaining ERPs and EROs to task-irrelevant events in the same sensory modality as that of the continuous sensory input, produces minimal interference with the main focus of attention on the video stream

    Ekimia ozcan-secmenii (Apiaceae), a new species from Southwest Anatolia, Turkey

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    Ekimia ozcan-secmenii Senol & Eroglu sp. nov. (Apiaceae) is described from SW Turkey. E. ozcan-secmenii differs from its close affinity, E. bornmuelleri, by life form (monocarpic), petal and bracteole morphology, and mericarp features. These data were more supported by the results of nrDNA ITS sequences. The ML tree depicted based on phylogenetic studies aimed to reveal the closeness of the Laserpitium and Prangos species as well as the location the affinity of species in the genus Ekimia. The taxonomic situation of Prangos hulusi was also evaluated based on nrDNA ITS sequences. Since E. ozcan-secmenii is distributed in Sami Soydam Sandalcik hydroelectric power plant in Acipayam, Denizli, the population is threatening by flooding. Therefore, conservation programs are urgently recommended.TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TBAG-108T851]The author would like to thank the curators of GAZI and EGE Herbaria for their helpful assistance. We also thank Prof Dr Hayri Duman for his help and comments on the species. This research was financially supported by TUBITAK (TBAG-108T851)
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