234 research outputs found
Athanasios N. Papathanasiou, Οι Νόμοι των Ομηριτών. Ιεραποστολική προσέγγιση και ιστορική -νομική συμβολή
No full textAthanasios N. Papathanasiou, Οι Νόμοι των Ομηριτών. Ιεραποστολική προσέγγιση και ιστορική -νομική συμβολή. In: Revue des études byzantines, tome 53, 1995. p. 402
Athanasios N. Papathanasiou, Οι Νόμοι των Ομηριτών. Ιεραποστολική προσέγγιση και ιστορική -νομική συμβολή
No full textAthanasios N. Papathanasiou, Οι Νόμοι των Ομηριτών. Ιεραποστολική προσέγγιση και ιστορική -νομική συμβολή. In: Revue des études byzantines, tome 53, 1995. p. 402
Transient transport of polymer solution flow in porous media
No full textKazakhstan takes 12th place in World oil production, however 52,7 % of produced oil comes from “mature” fields that are on the last production stages. Therefore, use of enhanced oil recovery methods becomes essential; one of these methods is polymer flooding, which involves injecting a polymer solution into the reservoir in order to displace trapped oil towards the wellbore. For successful injection of polymer solutions in a reservoir it is essential to study properly their behavior in porous media. This master thesis focuses on that topic, by describing and understanding two main factors that have a great impact on polymer transport, namely (i) the inaccessible pore volume (IPV) and (ii) polymer retention due to its adsorption on grain surfaces within the porous medium. In order to reach this goal experiments on core samples (plugs) were conducted, and effluent concentration profiles were obtained. Moreover, numerical modelling was implemented to characterize diffusion/adsorption of polymer molecules inside the porous core
Politics, Society and Culture in Orthodox Theology in a Global Age
No full textThe articles in the book show that today’s Orthodox theology is constructively relating to modernity in politics, society and culture. In 20 articles very prominent Orthodox theologians and experts on Orthodox theology and Orthodox Christianity from academic fields like sociology of religion or political studies are discussing, in what sense politics, society and culture are considered in Orthodox Theology in a global horizon. Contributors are Alfons Brüning, Ina Merdjanova, Nathaniel Wood, Cyril Hovorun, Dimitrios Moschos, Lucien Turcescu, K. M. George (Kondortha), Pantelis Kalaitzidis, Branko Sekulić, Georgios Vlantis, Nikolaos Asproulis, Atanas Slavov, Sveto Riboloff, Haralambos Ventis, Ioannis Kaminis, Irena Pavlović, Athanasios N. Papathanasiou, Chris Durante, Kateřina Kočandrle Bauer, Vasilios N. Makrides
Politics, Society and Culture in Orthodox Theology in a Global Age
No full textThe articles in the book show that today’s Orthodox theology is constructively relating to modernity in politics, society and culture. In 20 articles very prominent Orthodox theologians and experts on Orthodox theology and Orthodox Christianity from academic fields like sociology of religion or political studies are discussing, in what sense politics, society and culture are considered in Orthodox Theology in a global horizon. Contributors are Alfons Brüning, Ina Merdjanova, Nathaniel Wood, Cyril Hovorun, Dimitrios Moschos, Lucien Turcescu, K. M. George (Kondortha), Pantelis Kalaitzidis, Branko Sekulić, Georgios Vlantis, Nikolaos Asproulis, Atanas Slavov, Sveto Riboloff, Haralambos Ventis, Ioannis Kaminis, Irena Pavlović, Athanasios N. Papathanasiou, Chris Durante, Kateřina Kočandrle Bauer, Vasilios N. Makrides
Towards continuous biomanufacturing a computational approach for the intensification of monoclonal antibody production
No full textCurrent industrial trends encourage the development of sustainable, environmentally friendly processes with reduced energy and raw material consumption. Meanwhile, the increasing market demand as well as the tight regulations in product quality, necessitate efficient operating procedures that guarantee products of high purity. In this direction, process intensification via continuous operation paves the way for the development of novel, eco-friendly processes, characterized by higher productivity compared to batch (Nicoud, 2014). The shift towards continuous operation could advance the market of high value biologics, such as monoclonal antibodies (mAbs), as it would lead to shorter production times, decreased costs, as well as significantly less energy consumption (Konstantinov and Cooney, 2015, Xenopoulos, 2015). In particular, mAb production comprises two main steps: the culturing of the cells (upstream) and the purification of the targeted product (downstream). Both processes are highly complex and their performance depends on various parameters. In particular, the efficiency of the upstream depends highly on cell growth and the longevity of the culture, while product quality can be jeopardized in case the culture is not terminated timely. Similarly, downstream processing, whose main step is the chromatographic separation, relies highly on the setup configuration, as well as on the composition of the upstream mixture. Therefore, it is necessary to understand and optimize both processes prior to their integration. In this direction, the design of intelligent computational tools becomes eminent. Such tools can form a solid basis for the: (i) execution of cost-free comparisons of various operating strategies, (ii) design of optimal operation profiles and (iii) development of advanced, intelligent control systems that can maintain the process under optimal operation, rejecting disturbances. In this context, this work focuses on the development of advanced computational tools for the improvement of the performance of: (a) chromatographic separation processes and (b) cell culture systems, following the systematic PAROC framework and software platform (Pistikopoulos et al., 2015). In particular we develop model-based controllers for single- and multi-column chromatographic setups based on the operating principles of an industrially relevant separation process. The presented strategies are immunized against variations in the feed stream and can successfully compensate for time delays caused due to the column residence time. Issues regarding the points of integration in multi-column systems are also discussed. Moreover, we design and test in silico model-based control strategies for a cell culture system, aiming to increase the culture productivity and drive the system towards continuous operation. Challenges and potential solutions for the seamless integration of the examined bioprocess are also investigated at the end of this thesis.Open Acces
Dynamic modelling of an immobilized enzyme bioreactor
No full textBibliography: p. 81-84.Dynamic experiments provide an excellent means for the determination of crucial process parameters, such as the axial Peclet number, the intraparticle and external mass transfer coefficient and the intraparticle reaction rate constant, in fixed or liquid fluidized bed immobilized enzyme bioreactors. The absence of a complete and comprehensive solution of the model equations in the real time domain, as well as significant advances in the area of statistical moments analysis has rendered the latter approach the dominant one for parameter estimation in fluid-solid reacting systems. Nevertheless, an efficient and easily implementable solution of the model equations in the real time domain, as opposed to the solution in the Laplace domain needed for the statistical moments analysis, opens new possibilities in the design of fixed or fluidized bed bioreactors since, apart from parameter estimation via dynamic experiments, it is suitable for simulation, optimization and control. This paper presents a dynamic model for a fixed or liquid fluid bed immobilized enzyme bioreactor, along with a novel method for the solution of the coupled partial differential equations in the real time domain. Both, the tanks-inseries and the dispersion models have been used to describe the non ideal axial mixing in the reactor. The solution, in its final form, comes in both cases as a system of simultaneous ordinary differential equations; this is readily implementable on a computer and can be easily solved by commercially available software packages. Based on this solution, a complete parametric analysis was performed. That analysis revealed the importance of intraparticle and external mass transfer resistances, intraparticle chemical reactio?? and axial dispersion on the transient behaviour of the reactor. Most important, that analysis revealed ways for parameter estimation and system identification via simple dynamic experiments. The design and optimization implications of the study are finally demonstrated by using the derived solution to simulate the performance of an immobilized urease bioreactor with a recycle loop. Such a configuration is characterized by time varying feed concentration and can be used, as part of an extracorporeal artificial kidney device, for the treatment of uremic patients
A Study of Cell Signalling in the Human Fallopian Tube
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Lightweight Transactions on Networks of Workstations
No full textAlthough transactions have been a valuable abstraction of atomicity, persistency, and recoverability, they have not been widely used in programming environments today, mostly because of their high overheads that have been driven by the low performance of magnetic disks. A major challenge in transaction-based systems is to remove the magnetic disk from the critical path of transaction management. In this paper we present PERSEAS , a transaction library for main memory databases that decouples the performance of transactions from the magnetic disk speed. Our system is based on a layer of reliable main memory that provides fast and recoverable storage of data. We have implemented our system as a user-level library on top of the Windows NT operating system in a network of workstations connected with the SCI interconnection network. Our experimental results suggest that PERSEAS achieves performance that is orders of magnitude better than traditional recoverable main memory systems. 1 Intro..
Family Members’ of Coronary, Cardiosurgery and General ICU Patients Resilience, Perceived Stress, Spirituality: a Cross Sectional Analysis
No full textBackground: Family members’ of coronary, car-diosurgery and general ICU patients are psycho-logically burdened, shaken, experiencing negative emotions such as fear, anxiety, sadness and despair due to the severity of the disease and possible death. Objective: To investigate family members’ resilience in correlation with perceived stress and spirituality of coronary, cardiosurgery and general ICU Patients. Methods: A cross-sectional study was conducted on a random sample of 104 family members of patients (34 men and 70 women), admitted in the coronary, cardiosurgery and general ICU for greater than 48 hours. The PSS-14 was used to assess perceived stress. Resilience was investigated using CD-RISC-25 and spirituality using DSES. Also APACHE II was used to assesses the severity of the disease and the outcome of patients admitted to the ICU. Results: Resilience is significantly corre-lated with the scales of perceived stress (p <0.001) and daily spirituality (p = 0.019). On the contrary, the more their daily spirituality, the greater their resilience.In the present study no significant association was found between the DSES and the PSS-14. Conclusion: The main findings of the present study is the significant association between resilience and spirituality and perceived stress. Therefore, it is necessary to design interventions aiming at enhancing resilience, limiting perceived stress and promoting spirituality. © 2022 Iokasti Papathanasiou
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