326,214 research outputs found
Domestic Violence Against Single, Never-Married Women in the Occupied Palestinian Territory Assaf
No full textAssaf (S.) [L'organisation judiciaire post-talmudique], 1924
No full textBack Abraham. Assaf (S.) [L'organisation judiciaire post-talmudique], 1924. In: Revue des études juives, tome 83, n°165, janvier-mars 1927. p. 106
Behaviour Risk Factor Surveillance Data Analysis using Time-Varying Coefficient Models: Application to Smokers in Italy
No full textFDI Contribution to Capital Flows and Investment in Capacity
No full textThe paper surveys a theory of FDI, which captures a unique feature: hands-on management standards, that enable investors to react in real time to a changing economic environment. Equipped with superior managerial skills, foreign direct investors are able to outbid portfolio investors for the top productivity firms in a particular industry in which they have specialized in the source country. Consequently, FDI investors would make investment, both larger, and of higher quality (namely, with large rates of returns), than the domestic investors. The theory can explain both two-way FDI flows among developed countries, and one-way FDI flows from developed to developing countries. Gains to the host country from FDI stem from the informational value of FDI. The predictions of the theory are consistent with evidence from panel data: larger FDI coefficients in the domestic investment and output growth regressions relative to the portfolio equity flow and international loan coefficients, reflect a more significant role for FDI in the domestic investment process than other types of capital inflows.
An optimistic vision for biosciences in South Africa: reply to Thaldar et al. (2019)
No full textOur reply to Thaldar et al.’s1
response to the ASSAf report2
on human genetics and genomics focuses on two
elements of the Report which they highlight, namely ubuntu and sovereignty. The lack of engagement with other
issues raised by Thaldar et al. does not acknowledge agreement with those view
Assaf (S.). Les pénalités dans le droit post-talmudique, matériaux pour l'histoire du droit juif. 1922
No full textBack Abraham. Assaf (S.). Les pénalités dans le droit post-talmudique, matériaux pour l'histoire du droit juif. 1922. In: Revue des études juives, tome 81, n°162, octobre-décembre 1925. p. 221
Le corps baroque dans les histoires comiques
No full textAssaf Francis. Le corps baroque dans les histoires comiques. In: Littératures classiques, n°36, printemps 1999. Le baroque en question(s) pp. 79-94
Application of the varying coefficient model to the behaviour risk factor surveillance data in Italy: a study of changing smoking prevalence among sub-populations
No full textBehaviour risk factor surveillance (BRFS) data can be an important source of information for studying changes in various health outcomes and risk factors. Results obtained from surveillance data analysis are vital for informing health policy interventions, particularly with regards to evolutionary aspects. The objective of this analysis was to recommend a method that can be used for analysing trends in the association among variables from large public health data sets. This was demonstrated by examining the changing effects of various covariates, representing different sub-populations, on smoking status over time
Genetic dissection of "Caulobacter crescentus" surface colonization
No full textDuring its biphasic life cycle Caulobacter crescentus switches from a planktonic to surface attached life style. This transition requires the continuous remodeling of the cell poles through the temporally and spatially coordinated assembly and disassembly of polar organelles like the flagellum, pili, and an adhesive holdfast. A genetic screen for mutants affected in surface binding and colonization led to the identification of various genes required for motility, pili, and holdfast biogenesis, suggesting a specific role for all three organelles in C. crescentus surface colonization. Several novel holdfast genes were identified, which are potentially involved in the synthesis and regulation of the polysaccharidic component of the holdfast. Quantitative surface binding studies during the C. crescentus cell cycle revealed that optimal attachment coincides with the presence of flagellum, pili, and holdfast at the same pole. This indicated that accurate temporal control of polar appendices is critical for surface colonization of C. crescentus and represents the first example for developmentally controlled bacterial surface adhesion. We have used genetic and biochemical analyzes to demonstrate that di-cyclic guanosine monophosphate (c-di-GMP) is a central regulatory compound involved in the timing of C. crescentus pole development. Mutants lacking the diguanylatecyclase PleD show a dramatic delay of holdfast formation during swarmer cell differentiation. In contrast, cells lacking the GGDEF-EAL composite protein CC0091 show premature holdfast formation, while overexpression of CC0091 also leads to a delayed appearance of holdfast. The observation that CC0091 is a c-di-GMP specific phosphodiesterase indicated that the antagonistic activities of PleD and CC0091 could be responsible for the correct timing of holdfast formation and flagellum ejection. Finally, our genetic screen identified a candidate for the c-di-GMP effector protein, which mediates holdfast synthesis in response to fluctuating levels of c-di-GMP. The glycosyltransferase CC0095 is strictly required for holdfast formation and its overexpression leads to premature holdfast synthesis. This and the observation that CC0095 is able to bind c-di-GMP lead to the hypothesis that holdfast synthesis is
regulated via allosteric control of the CC0095 glycosyltransferase. These data provide the first
example of a developmental process being regulated by the bacterial second messenger, c-di-GMP
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