80 research outputs found
Substrate-Guided Design of a Potent and Selective Kallikrein-Related Peptidase Inhibitor for Kallikrein 4
No full textSummaryHuman kallikrein-related peptidase 4 (KLK4/prostase), a trypsin-like serine protease, is a potential target for prostate cancer treatment because of its proteolytic ability to activate many tumorigenic and metastatic pathways including the protease activated receptors (PARs). Currently there are no KLK4-specific small-molecule inhibitors available for therapeutic development. Here we re-engineer the naturally occurring sunflower trypsin inhibitor to selectively block the proteolytic activity of KLK4 and prevent stimulation of PAR activity in a cell-based system. The re-engineered inhibitor was designed using a combination of molecular modeling and sparse matrix substrate screening
The Midwest Quarterly; Vol. 23 No. 2
No full textin this issue. . .
WILLIAM M. CLEMENTS explores psychological maturation in Anaya’s Bless Me, Ultima. Professor of English at Arkansas State University, Clements has published articles on folklore and popular culture.
THOMAS L. HARTSHORNE reveals the traditionalist lurking behind the with-it façade constructed by Tom Wolfe in his writings on the 1960\u27s. Hartshorne\u27 s interest in recent cultural history has found expression in articles and in the book, The Distorted Image: Changing Interpretations of the American Character since Turner. Hartshorne teaches history at Cleveland State University.
RICHARD MOORE conjures the poetic nature of mathematics through the delightful Tristram, a character soon to find a voice in two other journals. Moore\u27s poems have enjoyed a wide audience, and his third book, Empires, a collection of narrative poems, was published this past Fall.
JAMES COOPER is a student in the MFA program at Wichita State University.
JONATHAN HOLDEN is a poet and critic teaching creative writing at Kansas State University. His latest book is a collection of essays, The Rhetoric of the Contemporary Lyric, from Indiana University Press (1980).
THOMAS P. LYNCH is director of the Richardson-Byrd-Lynch Funeral Home in Milford, Michigan. He has work in a recent issue of Poetry.
ANTHONY SOBIN teaches in the creative writing program at Wichita State. His first book of poems, The Sunday Naturalist, will appear next year from Ohio University Press.
THOM TAMMARO teaches at Ball State University, Muncie, Indiana, and edits for the Barnwood Press Cooperative, which publishes chapbooks, broadsides, and a magazine.
JUDITH WEISSMAN finds in Browning\u27s women dimension and humanity, individuality beyond symbol and purpose. Author of many essays on poetry and fiction in the nineteenth century, Weissman teaches English at Syracuse University.
WILSON O. CLOUGH examines the changes wrought by ideas and their culmination in the American Revolution. A scholar now retired from a distinguished career in English and American Studies at the University of Wyoming, Clough has recently brought out a revised second edition of his investigation of the Intellectual Origins of American National Thought.
JAMES C. WILSON illumines the myth of the symbolic journey revealed in Twain\u27s unfinished work, The Great Dark. A doctoral student at the University of New Mexico with previous work at the University of Nebraska, Wilson has published both fiction and criticism in several magazines, including a recent article on Melville\u27s Bartleby.
[A view of Fort Harmer at 100 yards distance from projecting angle of a bastion].
No full textFinished, colored, elevation sketch showing three bastions and two curtains of Fort Harmar.; Title taken from verso.; Attribution of author based on style and handwriting on verso
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