2,374 research outputs found

    Sara Winthrop Smith letter to Frances Casement, August 14, 1887

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    Letter written to Frances Casement from Sara Winthrop Smith of Cincinnati, Ohio, August 14, 1887. Winthrop expresses the challenges of generating support for the suffrage movement among the conservative residents of her city, and encourages the creation of clear materials that make the argument for women's suffrage to be more widely distributed. This item comes from the Frances Jennings Casement Papers, a manuscript collection comprised of letters and association records related to the founding and leadership of the Ohio Woman Suffrage Association. Casement (1840-1928) was born in Painesville, Ohio, and graduated from Painesville Academy and Willoughby Female Seminary. Her father, Charles Casement, supported abolition and women's suffrage and encouraged Frances to be active in social causes. Frances Casement established the Painesville Equal Rights Association in 1883, and shortly after became involved in the Ohio Woman Suffrage Association, serving as its president from 1885 to 1888

    Jane Jones letter to Frances Casement, November 11, 1887

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    This brief letter written by Jane Jones of Piqua, Ohio, to Frances Casement indicates that, while Ms. Jones is a temperance supporter, she does not support the suffrage movement and has passed a selection of promotional materials to a colleague at the local chapter of the Woman's Christian Temperance Union who is a suffrage proponent. This item comes from the Frances Jennings Casement Papers, a manuscript collection comprised of letters and association records related to the founding and leadership of the Ohio Woman Suffrage Association. Casement (1840-1928) was born in Painesville, Ohio, and graduated from Painesville Academy and Willoughby Female Seminary. Her father, Charles Casement, supported abolition and women's suffrage and encouraged Frances to be active in social causes. Frances Casement established the Painesville Equal Rights Association in 1883, and shortly after became involved in the Ohio Woman Suffrage Association, serving as its president from 1885 to 1888

    Intimate Horizons: The Post-Colonial Sacred in Australian Literature by Bill Ashcroft, Frances Devlin-Glass and Lyn McCredden.

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    Intimate Horizons: The Post-Colonial Sacred in Australian Literature by Bill Ashcroft, Frances Devlin-Glass and Lyn McCredden

    Mrs. J. H. Ammon letter to Frances Casement, December 24, 1884

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    Letter from Josephine M. (Mrs. J. H.) Ammon of Cleveland to Frances Casement, December 24, 1884. Ammon expresses her thanks to Casement and her fellow suffrage supporters in Painesville, Ohio, for recently hosting Ammon and other women from Cleveland. She discusses an upcoming lecture to take place titled "Should Women Vote?" and explores options to combine efforts in the region with regard to public lectures. This item comes from the Frances Jennings Casement Papers, a manuscript collection comprised of letters and association records related to the founding and leadership of the Ohio Woman Suffrage Association. Casement (1840-1928) was born in Painesville, Ohio, and graduated from Painesville Academy and Willoughby Female Seminary. Her father, Charles Casement, supported abolition and women's suffrage and encouraged Frances to be active in social causes. Frances Casement established the Painesville Equal Rights Association in 1883, and shortly after became involved in the Ohio Woman Suffrage Association, serving as its president from 1885 to 1888

    Mrs. M. B. Haven letter to Frances Casement, September 25, 1884

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    Letter from Mrs. Martha (M. B.) Haven of Cleveland, Ohio, to Frances Casement, September 25th, 1884. Haven encloses petitions and requests Casement's assistance in collecting names to protest the decision of Adelbert College to close admission to women. Adelbert College (originally named Western Reserve College) would go on to stop admitting women in 1888; female students were instead enrolled in the College for Women of Western Reserve University, though the two schools continued to cooperate closely for years. After a series of mergers between a number of other schools and colleges, the institution would be known as Case Western Reserve University beginning in 1967. This item comes from the Frances Jennings Casement Papers, a manuscript collection comprised of letters and association records related to the founding and leadership of the Ohio Woman Suffrage Association. Casement (1840-1928) was born in Painesville, Ohio, and graduated from Painesville Academy and Willoughby Female Seminary. Her father, Charles Casement, supported abolition and women's suffrage and encouraged Frances to be active in social causes. Frances Casement established the Painesville Equal Rights Association in 1883, and shortly after became involved in the Ohio Woman Suffrage Association, serving as its president from 1885 to 1888

    Mrs. M. B. Haven letter to Frances Casement, September 29, 1884

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    Letter from Mrs. Martha (M. B.) Haven of Cleveland, Ohio, to Frances Casement, September 29th, 1884. Haven writes concerning the decision of Adelbert College to close admission to women and her actions and intentions to protest this decision. Adelbert College (originally named Western Reserve College) would go on to stop admitting women in 1888; female students were instead enrolled in the College for Women of Western Reserve University, though the two schools continued to cooperate closely for years. After a series of mergers between a number of other schools and colleges, the institution would be known as Case Western Reserve University beginning in 1967. This item comes from the Frances Jennings Casement Papers, a manuscript collection comprised of letters and association records related to the founding and leadership of the Ohio Woman Suffrage Association. Casement (1840-1928) was born in Painesville, Ohio, and graduated from Painesville Academy and Willoughby Female Seminary. Her father, Charles Casement, supported abolition and women's suffrage and encouraged Frances to be active in social causes. Frances Casement established the Painesville Equal Rights Association in 1883, and shortly after became involved in the Ohio Woman Suffrage Association, serving as its president from 1885 to 1888

    Metabolomics data for: Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells

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    These data support the paper "Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells". We have investigated the mechanism(s) by which chronic hyperglycaemia and diabetes lead to impaired β-cell metabolism and if this is linked to activation of mTORC1. We show that a glycolytic metabolite downstream of glucokinase and upstream of GAPDH mediates the effects of diabetes and chronic hyperglycemia on β-cell metabolism. This occurs, in part, through marked upregulation of mTORC1, which leads to changes in metabolic gene expression, oxidative phosphorylation and insulin secretion. AMPK is concomitantly downregulated. In addition, diabetes dramatically inhibits the activity of GAPDH and PDH, which impairs both glycolytic metabolism and entry into the TCA cycle. Our results support the idea that progressive impairment of β-cell metabolism, induced by increasing hyperglycaemia, speeds T2D development, and suggest that reducing glycolysis at the level of glucokinase may slow this progression. These data were produced from liquid chromatography-mass spectrometry analysis of: control and diabetic islets stimulated with 2 mM or 20 mM glucose (Fig. 3a,b & Suppl. Fig. 2), INS-1 (832/13) cells cultured for 48h with or without 5 μM koningic acid and subsequently stimulated with 2 mM or 20 mM glucose in the absence of koningic acid (Fig. 4a,b), and INS-1 cells cultured in 2 mM or 20 mM glucose (Suppl. Fig. 2). Anion-exchange chromatography-mass spectrometry (IC-MS) data were acquired on a Dionex IC-5000+ ion chromatography system hyphenated to a Thermo Fisher Scientific Q Exactive. Data are .zip compressed to reduce file size. Data files are in .raw format and require Thermo Fisher Scientific Xcalibur software to analyse
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