27 research outputs found
Cellular decision making at the nanoscale
No full textThe well-established dependence of cell traction forces on the compliance of supporting matrices has been attributed to levels of force exerted on components in focal contacts. Here, use of novel, force-limited nanoscale tension gauges revealed that both force and substrate deformations govern cell decision-making during initial attachment to compliant substrates. We propose a mechanical model consistent with observed behavior. Upon formation of stable cell contacts, bond tension and tether rupture govern cell attachment, spreading, and focal adhesion maturation at force levels on individual receptors predicted by prior studies.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-08-01The student, Zainab Rahil, accepted the attached license on 2016-04-27 at 06:49.The student, Zainab Rahil, submitted this Thesis for approval on 2016-04-27 at 06:55.This Thesis was approved for publication on 2016-04-29 at 14:30.DSpace SAF Submission Ingestion Package generated from Vireo submission #9538 on 2017-09-29 at 11:12:58Made available in DSpace on 2017-09-29T17:52:42Z (GMT). No. of bitstreams: 2
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Previous issue date: 2016-04-29Embargo set by: Colleen Fallaw for item 103531
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Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 103531 on 2019-09-30T09:15:23Z
Cells and force transduction
No full textThis thesis studies mechanism involved in propagating force generated at cadherin complexes. The first part of this thesis demonstrates that mechanotransduction at classical cadherin complexes is not only ligand-dependent but also dependent on the respective receptor tyrosine kinase (RTK) binding partner of cadherin. This involvement of RTKs at cadherin complexes is important in propagating force transduction globally, implying that force transduction at cadherin complexes is not restricted to cell-cell junctions but is also propagated globally via the mediation of its respective RTK binding partner. These results suggest that homophilic ligation in trans- and cadherin association with cognate receptor tyrosine kinase in cis comprises a combinatorial, mechano-chemical switch. That is, specific combinations of cadherin, ligand, and RTK is required for force-activated RTK-dependent signaling, activation of cell contractility, and cytoskeletal remodeling at perturbed cadherin adhesions. These findings confirm that cadherins form both homophilic and heterophilic bonds, but homophilic cadherin ligation selectively triggers cadherin-associated RTK signals that mechanically reinforce homophilic, but not heterophilic cadherin adhesions, thereby stabilizing homophilic adhesions and amplifying binding differences. This study demonstrates that this mechano-chemical switch is not governed by cadherin adhesion differences, but requires a specific combination of cadherin ligand in trans- and RTK expression in cis to actuate force transduction signaling on rigid surfaces to propagate force transduction at a global level.
For the second part of this study used novel, force-limited nanoscale tension gauges to investigate how force and substrate stiffness guide cellular decision-making during initial cell attachment and spreading on deformable substrates. The well-established dependence of cell traction and spreading on substrate stiffness has been attributed to levels of force exerted on molecular components in focal contacts. The molecular tension gauges used in this study enabled direct estimates of the threshold, pico Newton forces that instructed decision-making at different stages of cell attachment, spreading, and adhesion maturation. These results further confirm that the force thresholds controlling adhesion and spreading transitions depend on substrate stiffness. Reported findings agree semi-quantitatively with a proposed model that attributes rigidity-dependent differences in cell spreading to stiffness-dependent rates of competing biochemical processesSubmission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2020-12-01The student, Zainab Rahil, accepted the attached license on 2018-11-08 at 12:34.The student, Zainab Rahil, submitted this Dissertation for approval on 2018-11-08 at 12:48.This Dissertation was approved for publication on 2018-11-13 at 10:27.DSpace SAF Submission Ingestion Package generated from Vireo submission #13072 on 2019-02-08 at 11:38:31Made available in DSpace on 2019-02-08T18:39:44Z (GMT). No. of bitstreams: 2
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Previous issue date: 2018-11-13Embargo set by: Seth Robbins for item 109931
Lift date: 2021-02-08T18:40:00Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 109931
Lift date: 2021-02-08T18:42:23Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 109931
Lift date: 2021-02-08T18:43:54Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 109931
Lift date: 2021-02-08T18:44:50Z
Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemLimited Restriction Lifted for Item 109931 on 2021-02-09T10:15:38Z
Investigating the Role of Excellent Model in the Competitive Market with Impact on The Economy
No full textAbstract. Nowadays, gaining competitive advantage depends on the organization’s capability to moving towards excellence and superiority in various dimensions. Creating competition with ethical principles means that, with scientific methods and strategic planning step towards strengthening the organization performance in the competitive market. There are many ways to gain the competitive market advantage and all that need to be appropriate and accordance with the cultural, political, human and structural conditions. Between all ways, one of the solutions that is more culturally, humane, and structurally appropriate to the organizational and the local business environment, and in practice, some organizations have proven it to be as a high-value or excellent and standard model, can name a model of E.F.Q.M (EUROPEAN, FOUNDATION, QUALITY, MANAGEMENT).Research methodology – This paper focuses on a conceptual analysis of the relations among establishing an excellence model in the organization and gaining competitive advantage. Here the EFQM excellence model is considered as a suitable framework for achieving the competitive advantage in the market for the organization. The revision of academic literature and logical analysis are the main methodological tools.Findings – The study shows that establishing competitive advantage foundations and excellence model in the organization and then evaluate and assessing them based on the components mentioned here, can achieve competitive advantage for the organization in the global scale, and in this sense, it is possible to define relationships and impact between each component of excellent model and those coming from the model on the competitive advantage
Health Village and its place in the Health System
No full textBackground & Objectives: Health Village is a residential/healthcare place for natural remedies combined with other medical treatments. Health village can be set in different sizes, depending on the amount of investments and the investors’ strategic objectives. In fact, a complete health village can cover all aspects of health and meet all the health needs of a community.
Methods: In this review study, Persian and English articles indexed in valid databases such as Google Scholar, SID, Pubmed, Irandoc Science direct and Scopus were searched using the MESH terms of “ Health village” and “Health resort” without time limitation.
Results: Providing health services in natural areas and away from urban pollution can restore the health and well-being and also can cause psychological and physical relaxation not only in patients but also in those who are interested in living in places with services such as water therapy, herbal therapy, gravel treatments, mud therapy, and other services.
Conclusion: The effort to create environments such as the health village, due to the potential of such centers in providing high levels of physical and psychological comfort for audiences, can be considered as a beneficial local business. Therefore, the health village is an environment that can contribute to the social and economic development while serving the health of the community.
Keywords: Medical Tourism, Health village, Health system
Citation: Kochak Yazdi S, Asadi A, Ghorbani Nia R. Health Village and its place in the Health System. Journal of Health Based Research 2019; 5(1): 57 -71 . [In Persian
The Sustainable Links of Development between Leadership and Organizational Cultures
No full textLeadership performances develops closely connected to the institutional behaviour and societal culture given the permanent trends to implement changes to update standards according to existing norms and rigors existing in any company. The styles adopted in managing or leading the activities influences the tasks’ achievement, the future path to take and the way success is understood, accepted, shared and disseminated. Nowadays, companies face compulsory the influences of more cultures, given the temptation of delocalisation, the curiosity of working with immigrants, the advantages provided in different situations of accepting a higher exposure of leader to different sides of performance, different dimensions of market and financial profits, new behaviours in managing the employees. Starting from this idea, the purpose of this study is to identify and enquire into the hidden dimensions of organizational culture and how the leadership style impacts the strategic developing and let effective relations spring out.The research is built on a survey based on designed questioner applied to 550 leaders and employees, members of the operation and Maintenance Company of MAPNA (Q&M) in Iran. Data collected refers to MLQ leadership style and Denison's Organizational Culture Questionnaire, and the responses received were analysed with SPSS and Smart Plus software. The findings reveal that the relationship between the leadership style and the organizational culture are strongly linked to each other. Therefore, those leaders able to change and accept to use a transformational style will assist the company to move forward faster that those who adopt and keep the transactional style as the single one to prove important
How Globalization Influences the Developing Countries’ Human Resources Strategic Policy
No full textDevelopment of human resources is one of the key issues of today's economics and management scholars. Starting from the basic concepts of human resources – definition, trends of development, related indicators the present research evolves under three components: education, life expectancy and gross domestic product per capita. Figures that sustains our demarche flow according to the ranking data in terms of globalization index and The United Nations Human Development Index (HDI), calculated with the STATGRAF statistical software. We used the Spearman correlation coefficient and correlated the intensity between the two variables (R=76%), to show the close relationship between the Globalization Index and Human Resource Development. Taking such conclusions into consideration could make more successful the advances in the field of human resources
Mechanism and performance evaluation of spent-coffee grounds-derived nanocomposite materials for highly efficient photocatalytic degradation of organic pollutant
No full textThe study demonstrates a facile and environmentally friendly method for synthesizing crystalline TiO2 nanoparticles on the surface of hydrochar generated from readily available biomass waste, i.e., spent coffee grounds (SCGs), using a simple sol–gel process. The hydrochar served as a support for TiO2, reducing the rate at which electrons and holes recombine during photocatalysis, thereby facilitating the effective binding of TiO2, enhancing its adsorption capacity, and the convenient separation of the photocatalyst after usage. The materials were tested in the photocatalytic degradation of an organic pollutant, methylene blue (MB) dye. TiO2-hydrochar obtained at 210 ⁰C has the best performance, giving a degradation efficiency of 98.5 % and a mineralization efficiency of 87.1 % in 90 min at neutral pH. Radical trapping experiments showed
being the dominant species, followed by
. Besides, it showed superior stability with an activity loss of ∼ 9.2 % after five runs. The superior performance of the HCT210 was ascribed to the enhanced interfacial charge transfer kinetics between the TiO2 and hydrochar through
bond formation, better light absorption, and the high surface area of the materials. Performance metrics show that synthesized nanocomposites are promising photocatalysts, providing a biomass-assisted method for robust photocatalytic wastewater treatment.Killam TrustsNatural Science and Engineering Research Council (NSERC
House of Music : Festivity from city to seat
No full textHouse of Music : Festivity from city to seat.Concert HallArchitecture, Urbanism and Building Sciences | Interiors Buildings Citie
Knowledge Management and the Governmental Organisations
No full textAbstract.Nowadays, the concept of Knowledge Management is gradually being recognized in governmental establishments which are seeking to deploy their own knowledge management system and make the most of their existing knowledge in policymaking, by creating and maintaining a competitive advantage in the domestic and international environment.For an organisation, the intellectual assets and individual knowledge are as important as the other physical and financial assets. Knowledge is a primary resource featured to provide a competitive advantage to any organization that recognises and incorporates it efficiently in its processes.This article aims to review the value of knowledge management, the pillars by describing its cycle and highlighting its importance for governmental organisations. The obstacles and difficulties of implementing and deploying knowledge management in government organisations with suggested solutions that are also discussed.In conclusion, recommendations for decision makers are presented to enhance the efficiency of the knowledge management implementation and scale up the gain of a lasting competitive advantage within national and international environments
