854 research outputs found
A Method for Representing Contextualized Information (MeRCI) to Improve Situational Awareness Among Electronic Message Brokering System Dashboard Users
No full textElectronic health information brokering systems are of interest to public health informatics because they emphasize how data can be effectively shared and utilized across healthcare institutions and among providers so as to improve the quality of care, increase efficiency, and reduce costs (Lumpkin, 2002). In the domain of public health (PH) specifically, where complete and timely reporting of data is critical for all epidemiological and disease surveillance activities (Langmuir, 1976), it is imperative to ensure proper functioning of the electronic information exchange infrastructure. Receiving multiple types of data, in various formats from numerous sources, and triaging them to the appropriate surveillance system is no easy task for a department of health, whether at state, local or federal level (Magnuson, 2005).
The administrators of the electronic message brokering system, and the coordinators of surveillance systems in each public health jurisdiction, are responsible for ensuring that the data is received, archived, validated and triaged appropriately in a timely and complete fashion. This requires continuous monitoring of trends in messaging and system performance and active responses to aberrations. To achieve this, administrators depend heavily on dashboards to provide awareness of exchange system status and its reporting at any point of time. Unfortunately, current dashboards do not offer the context or cognitive support needed for interpreting the information presented. As research has demonstrated in other domains, in order to make sense of the data and react, dashboard users are required to draw upon domain knowledge, higher level association between domains, operational rules, organizational missions, personal objectives, tasks at hand, priorities, past experiences, historic events, recent events, psychosocial and political constructs, and more (Resnick, 2005; Mirhaji, Srinivasan, Casscells, & Arafat, 2004). The burden of ‘interpretation’ always falls on the cognitive system of the human operator, which is prone to error and malfunctioning when risk and emergency overwhelm psychological factors (Parsa, Richesson, Smith, Zhang, & Srinivasan, 2004; Parsa, Zhang, Smith, Majid, Casscells, & Lillibridge, 2003). On the basis of the surveillance literature it can be seen that meaningful and holistic interpretation of data requires the generation of higher-level explanations based on knowledge and expertise from numerous principles (Parsa, Richesson, & Srinivasan, 2004; Parsa, Richesson, Smith, Zhang, & Srinivasan, 2004), while context is essential to illustrate the ‘big picture’ view of dynamic and complex problems (Parsa, Zhang, Smith, Majid, Casscells, & Lillibridge, 2003). These reservations imply that the process for building health information dashboards should consider not only user functions, tasks and goals but also the user’s situational awareness (SA) requirements. This vision adds a new layer to information representation that needs to be accounted for when conceptualizing the implementation of health information dashboards. A review of the literature reveals a lack of methods to design for situational awareness in dashboard systems in complex domains (Resnick, 2005; Li, 2007).
This research introduces a new method to present contextualized information that can improve user SA. I present the design rationale, method, and results of an evaluation study that measures the situational awareness generated by adopting this new context-driven representation model
Bronze image casting in Tanjavur District, Tamil Nadu: Ethnoarchaeological and archaeometallurgical insights
No full textThe profusion of metal images made in the Tanjavur region, going back to the early medieval Chola
bronzes of the 9th-13th century ranks amongst the finest of Indian artistic expressions. Clusters of artistic and
artisanal activities have thrived over generations in the Tanjavur district including metalworking workshops for
bronze and bell metal casting of images and ritual objects especially around Swamimalai and Kumbakonam.
Ethnometallurgical and archaeometallurgical insights on the making of icons at Swamimalai are highlighted from
observations made over the past couple of decades, especially in relation to making comparisons with historical
practices of bronze casting going back to Chola times. Since the processes are rapidly undergoing change, to get
a better sense of the trajectory of past practices, this paper particularly aims to highlight unpublished observations
made by the author going back to her first visits in 1990-1, as background to her doctoral work (Srinivasan 1996)
and in relation to observations reported by other scholars going back to the early landmark efforts of Reeves (1962).
These observations were particularly made by the author at the workshop of late master craftsman Devasena
Sthapathy, in his time the most renowned of Swamimalai Sthapathis. His son Radhakrishna Sthapathy has now
inherited this mantle. While Levy et al (2008) give a more recent account of image casting at the workshop of
Radhakrishna Sthapathy, this paper attempts to also contextualise the previous trajectory that has not been covered
much therein. Since their workshop now goes under the name of Sri Jayam Industries, for the sake of convenience
it will be referred here by the same name
Redescrição de Cymodoce madrasensis (Srinivasan, 1959) combinação nova (Sphaeromatidae: Isopoda: Crustacea) de Madras, Índia
No full textO autor estudou quase todas as espécies da família Sphaeromatidae (Isopoda), da Coleção de Crustacea do USNM, e a espécie constante do catálogo 102151 USNM, na época, não possuia identificação razão pela qual o autor enquadrou no gênero Cymodoce. Hoje está classificada como Exosphaeroma madrasensis Srinivasan, 1959. Este gênero não condiz com as características da espécie motivo pelo qual o autor procedeu a transferência para o gênero Cymodoce Leach, 1814, e estabeleceu nova combinação Cymodoce madrasensis (Srinivasan, 1959).The author studying a male of Exosphaeroma madrasensis Srinivasan, 1959, catalog 102151 Division of Crustacea - USNM, describes and transfers the species to the genus Cymodoce Leach, 1814 establishing a new combination Cymodoce madrasensis (Srinivasan, 1959)
A class of gorenstein artin algebras of embedding dimension four
No full textIn this article, we study height four graded Gorenstein ideals I in k[x, y, z, w] such that I2 is of height one and generated by three quadrics. After a suitable linear change of variables, I ∩ k[x, y, z] is either Gorenstein or of type two. The former case was studied by Iarrobino and Srinivasan [8] where they give the structure of the ideal and its resolution. We study the latter case and give the structure of these ideals and their minimal resolution. We also explicitly write the form of the generators of I and the maps in the free resolution of R-I. © Taylor andamp; Francis Group, LLC.Artin E., 1957, INTERSCIENCE TRACTS, V3; BROWN A, 1984, THESIS BRANDEIS U WA; BROWN AE, 1987, J ALGEBRA, V105, P308, DOI 10.1016-0021-8693(87)90196-7; BUCHSBAUM DA, 1977, AM J MATH, V99, P447, DOI 10.2307-2373926; BUCHSBAU.DA, 1973, J ALGEBRA, V25, P259, DOI 10.1016-0021-8693(73)90044-6; Eisenbud D., 1994, GRADUATE TEXTS MATH, V150; ELKHOURY S, 2007, THESIS U MISSOURI MI; Iarrobino A, 2005, J PURE APPL ALGEBRA, V201, P62, DOI 10.1016-j.jpaa.2004.12.015; KUSTIN A, 1982, T AM MATH SOC, V270, P287, DOI 10.2307-1999773; Macaulay F. S., 1994, ALGEBRAIC THEORY MOD; Srinivasan H., 2003, ADV ALGEBRA GEOMETRY, P93; SRINIVASAN H, 1977, CONT MATH, V99, P44711
R19. Investigation of Taste Masking Efficiency of Caffeine Citrate by Lipids Utilizing Hot Melt Extrusion Technology
No full textCorresponding author (Pharmaceutics and Drug delivery): Priyanka Srinivasan, [email protected]://egrove.olemiss.edu/pharm_annual_posters/1018/thumbnail.jp
Notch Signaling: Mechanistic And Functional Studies In Intestinal Stem Cells And Colorectal Cancer Cells
No full text: The study of stem cell regulation in intestinal and colonic tissues is an area of significant focus within the scientific community, providing mechanistic insight into biological process and offering translational clinical potential. In this thesis we address the contribution of NOTCH signaling in maintaining the stem cell niche by modulating the mode of stem cell division and receptor-ligand interactions for cell-cell communication. Furthermore, we examine NOTCHmediated spatiotemporal recovery of the intestinal stem cell (ISC) niche following single cell ablation. Finally, we demonstrate that elevated NOTCH signaling exists under conditions of physiological stress and in colon cancer initiating cells (CCICs), promoting tumorigenic potential of the intestinal epithelium. Overall, our research highlights the underlying complexities of NOTCH signaling as an essential pathway to maintain intestinal homeostasis and may inspire development of novel CRC therapeutic strategies. Research efforts and findings during my graduate study have been consolidated into the following peer-reviewed publications, of which the four first co-author manuscripts are described in detail in this dissertation. 1. Srinivasan, Tara; Walters, Jewell; Bu, Pengcheng; Than, Elaine B.; Tung, Kuei-Ling; Chen, Kai-Yuan; Panarelli, Nicole; Milsom, Jeff; Augenlicht, Leonard; Lipkin, Steven M; Shen, Xiling. "NOTCH Signaling Regulates Asymmetric Division of Fast- and Slow-Cycling Colon Cancer Initiating Cells." Cancer Research, 2016. (in press) 2. Srinivasan, Tara; Than, Elaine B.; Bu, Pengcheng; Tung, Kuei-Ling; Chen, Kai-Yuan; Augenlicht, Leonard; Lipkin, Steven M.; Shen, Xiling. "NOTCH Signaling Regulates Fast- and Slow-Cycling Intestinal Stem Cells." Scientific Reports, 2016. (in press) 3. Chen, Kai-Yuan*; Srinivasan, Tara*; Choi, Jiahn*; Bu, Pengcheng; Tung, Kuei-Ling; Nishimura, Nozomi; Shen, Xiling. "Dynamic regulation of intestinal stem cell niche recovery in real-time." Cell Systems, 2015. (in review) 4. Murthy, Preetish KL*; Srinivasan, Tara*; Bochter, Skye; Bu, Pengcheng; Cole, Susan; Shen, Xiling. "FRINGE-dependent modification of NOTCH Ligands in Intestinal Stem Cells." 2016. (in preparation) 5. Rothschild, Daniel; Srinivasan, Tara; Aponte-Santiago, Linette; Shen, Xiling; Irving, Allen. "The Ex Vivo Culture and Pattern Recognition Receptor Stimulation of Mouse Intestinal Organoids." JoVE, 2015. (in press) 6. Bu, Pengcheng*; Wang, Lihua*; Chen, Kai-Yuan; Srinivasan, Tara; Lakshminarasimha, Preetish; Tung, Kuei-Ling; Varanko, Anastasia; Ai, Yiwei; Lipkin, Steven; Shen, Xiling. "miR34a and Numb synergize for asymmetric cell fate determination." Cell Stem Cell, 2016 Feb 4;18(2):189-202. 7. Crespo, Miguel; Tsai, Su-Yi; Srinivasan, Tara; Pipalia, Nina; Maxfield, Nina; Lipkin, Steven M; Evans, Todd; Chen, Shuibing. "Colonic Organoids Derived from Human Pluripotent Stem Cells for Modeling Colorectal Cancer and Drug Testing." Nature Medicine, 2015. (in review) 8. Wang, Lihua*; Bu, Pengcheng*; Ai, Yiwel; Srinivasan, Tara; Lipkin, Steven M; Shen, Xiling. "A Long Non-Coding RNA Targets MicroRNA miR-34a to Regulate Colon Cancer Stem Cell Asymmetric Division." eLife, 2016. (in press
Neural geolocation prediction in Twitter
No full textInferring the location of a user has been a valuable step for many applications that leverage social media, such as marketing, security monitoring and recommendation systems. Motivated by the recent success of Deep Learning techniques for many tasks such as computer vision, speech recognition, and natural language processing, we study the application of neural models to the problem of geolocation prediction and experiment with multiple techniques to analyze neural networks for geolocation inference based solely on text. Experimental results on the dataset suggest that choosing appropriate network architecture can all increase performance on this task and demonstrate a promising extension of neural network based models for geolocation prediction. Our systematic extensive study of four supervised and three unsupervised tweet representations reveal that Convolutional Neural Networks (CNNs) and fastText best encode the the textual and geoloca- tional properties of tweets respectively. fastText emerges as the best model for low resource settings, providing very little degradation with reduction in embedding size.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-05-01The student, Pramod Srinivasan, accepted the attached license on 2017-04-25 at 12:15.The student, Pramod Srinivasan, submitted this Thesis for approval on 2017-04-25 at 12:51.This Thesis was approved for publication on 2017-04-25 at 18:42.DSpace SAF Submission Ingestion Package generated from Vireo submission #11043 on 2017-08-10 at 14:32:36Made available in DSpace on 2017-08-10T19:52:23Z (GMT). No. of bitstreams: 2
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Gorenstein hilbert coefficients
No full textWe prove upper and lower bounds for all the coefficients in the Hilbert polynomial of a graded Gorenstein algebra S = R-I with a quasi-pure resolution over R. The bounds are in terms of the minimal and the maximal shifts in the resolution of R. These bounds are analogous to the bounds for the multiplicity found in [9] and are stronger than the bounds for the Cohen Macaulay algebras found in [5]. © 2013 Rocky Mountain Mathematics Consortium.Boij M, 2008, J LOND MATH SOC, V78, P85, DOI 10.1112-jlms-jdn013; Bruns W., 1993, CAMBR STUD ADV MATH, V39; PESKINE C, 1974, CR ACAD SCI A MATH, V278, P1421; Eisenbud D, 2009, J AM MATH SOC, V22, P859; El Khoury S., 2011, INT J ALG, V5, P679; Herzog J, 1998, T AM MATH SOC, V350, P2879, DOI 10.1090-S0002-9947-98-02096-0; Herzog J, 2009, P AM MATH SOC, V137, P487; HUNEKE C, 1985, CAN J MATH, V37, P1149, DOI 10.4153-CJM-1985-062-4; Srinivasan H, 1998, J ALGEBRA, V208, P425, DOI 10.1006-jabr.1998.74130
Expulsive choroidal haemorrhage
No full textExpulsive choroidal haemorrhage is a dramatic and serious complication of cataract surgery that occurred in five patients out of ten thousand consecutive cataract surgeries performed by the author during the year 1989 and 1990. Report about this dreaded complication after cataract surgery are scanty and as far as I can remember I have not seen any report in Indian ophthalmic literature recently. Since cataract surgery forms the major part of intra ocular surgeries performed in our country, I thought it would be appropriate to report about this rare complication which may occur to all of us. Out of five cases 3 were males and 2 were females in the age group ranging between 45-72 years. Two eyes regained vision up to 6/12 after intra operative expulsive haemorrhage. All the eyes were salvaged by doing anterior sclerotomy. Diabetes, hypertension, glaucoma and myopia are the commonest predisposing factors
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