71 research outputs found
Teleskopik arkus aorta : Marfan sendromunda yeni bir antite
Full text linkTeleskopik arkus aorta, Marfan sendromunda aortik diseksiyon sonu- cu oluşabilen ve daha önceden rapor edilmemiş bir antitedir. Burada bir adli otopside tespit edilen ve kronik aort diseksiyonuna ikincil ilk teleskopik arkus aorta olgusu bildirilmiştir. 20 yaşında bir erkekte as- sendan aorta rüptüründen kaynaklanan kalp tamponadı sonucu ani ölüm olgusu sunulmuştur. Otopside, serbest ve pıhtılı kandan oluşan 800 cc’lik bir hemoperikardium olduğu dikkati çekmiştir. Assendan torasik aortanın dilate olduğu ve ön duvar mediailinde 1,2 cm’lik tam kat duvar rüptürü olduğu tespit edilmiştir. Aort muayenesinde, arkus aorta içerisinde bir tüp gibi yerleşmiş ikinci bir arkus aorta olduğu dikkati çekmiştir. İçteki bu ikinci arkın aort kapaklarının 2,5 cm üzeri- nden başladığı ve desseden aorta başlangıcında sonlandığı; ayrıca 10 cm uzunluğunda ve 2 cm çapında olup trunkus brakiosefalikus, sol karotis kommonis ve sol subklavian arterle ilişkili olduğu saptanmıştır.Telescopic aortic arch is a consequence of aortic dissection in Marfan’s syndrome, which has not been reported previously. This paper pres- ents the first case of telescopic aortic arch secondary to chronic aortic dissection, as an incidental finding of a forensic autopsy. Here we present a sudden death of a 20 years old male due to cardiac tampon- ade sourcing from the rupture of ascending aorta. At autopsy, there was a haemopericardium of 800 cc, which comprised blood and clot. The ascending thoracic aorta was dilated and a 1.2 cm ragged linear complete rupture was noticed on the medial side of the front wall of ascending aorta. Examination of aorta showed a second/inner aortic arch just as a tube lying inside the aortic arch. The inner aortic arch was arrised 2.5 cm above aortic valves and lasted at the beginning of the descending aorta. It was 10 cm in length with a lumen 2 cm in diameter and was associated with truncus brachiosephalicus, left common carotid, and left subclavian arteries
ARSLAN BESÂSÎRÎ İSYANI VE BU İSYANIN SELÇUKLU-ABBASÎ-FATIMÎ DEVLETLERİ EKSENİNDE BÖLGE KADERİNE OLAN ETKİLERİ
No full textArslan Besâsirî isyanı yalnızca Abbasi Devleti’ne karşı yapılmış bir isyan olarak görülse de Selçuklu Devleti, Fatımi Devleti ve bölge emirliklerini de doğrudan etkileyen bir isyan olmuştur. Ayrıca Selçuklu Devleti Bünyesinde oluşan İbrahim Yınal isyanının da teşvikçisi konumundadır. Henüz daha yeni kurulmuş olan Selçuklu Devleti’nin ilk hükümdarı Tuğrul Bey döneminde meydana gelen bu gelişmeler, kısa sürede Selçuklu Devleti’nin beka meselesi haline geldi. Selçuklu Devleti, Fatımi Devleti’nin ciddi miktarda silah, para ve asker yardımları ile desteklediği bu isyanlardan hem kendisi için hem de Abbasi Devleti için mücadele etmek durumundaydı. Olası bir olumsuz gelişme, henüz yeni kurulmuş olan Selçuklu Devleti’ni yıkılmanın eşiğine getirebilecek seviyede idi. Aynı şekilde, devletin merkezi olan Bağdat’ı ve tahtını kaybetmiş olan Abbasi Halifeliğinin de sonunu getirebilirdi. Tüm bu kritik varsayımların neticesinde Selçuklu Devleti bu isyanlardan başarılı bir şekilde çıktı ve hem bölgede hem de İslam dünyasında saygınlığı ve otoritesi artmış bir devlet konumuna ulaştı. Bundan sonraki süreçte de Halifeliğin en büyük destekçisi olma vasfına sahip oldu. XI. Yüzyılın başlarında İslamiyet’i kabul eden Selçuk oğullarının, devlet kurduktan sadece 18 yıl sonra İslam ülkelerinin ve halifeliğin koruyucusu vasfına ulaşması, isyanın sonuçları arasında vurgulanması gereken bir diğer önemli husustur. Bu açıdan bakıldığında iki tehlikeli isyanı içerisinde barındıran bu olay silsilesi aslında İslam dünyası için de bir kırılmanın ve güç dengesinin değişmesine vesile olabilecek seviyedeydi.Although the rebellion of Arslan Bashāsirī is considered as a rebellion against the Abbasid State, it was a rebellion that directly affected the Seljuk State, the Fatimid State and the emirates of the region. It was also the instigator of the Ibrahim Yınal rebellion within the Seljuk State. These developments, which took place during the reign of Tugrul Beg, the first ruler of the newly established Seljuk State, soon became a matter of survival of the Seljuk State. The Seljuk State had to fight against these rebellions, which were supported by the Fatimid State with significant amounts of weapons, money and military aid, both for itself and for the Abbasid State. A possible unfavourable development could have brought the newly established Seljuk State to the brink of collapse. Likewise, the loss of the capital Baghdad and the throne of the Abbasid Caliphate could also spell the end of the state. As a result of all these critical assumptions, the Seljuk State emerged successfully from these revolts and became a state with increased prestige and authority both in the region and in the Islamic world. In the following period, they became the biggest supporter of the Caliphate. The fact that the Seljuk sons, who accepted Islam at the beginning of the XIth century, became the protector of Islamic countries and the Caliphate within only 18 years after establishing a state is another important issue that should be emphasised among the results of the rebellion. From this perspective, this chain of events, which included two dangerous rebellions, was actually significant enough to cause a rupture and a shift in the balance of power within the Islamic world
Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors
No full textA newly series of 4-(phenylurenyl) chalcone (4a-j) and 4'-(phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-L-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity. (C) 2011 Elsevier Ltd. All rights reserved
The Evaluation of Amyloidosis Cases with Renal Involvement: A Single-Center Experience
No full textOBJECTIVE: Amyloidosis is a chronic disease associated with proteinuria and can progress to renal failure. The diagnosis and treatment of the underlying cause is therefore important. In this study at a university hospital, the diagnosis of amyloidosis patients with renal biopsies was evaluated retrospectively.MATERIAL and METHODS: 69 (42 males, 27 females, mean age: 51.7 +/- 14.8 years) patients were diagnosed with amyloidosis with renal biopsy. Indications for biopsy was nephrotic syndrome in 42 patients (60.9%), nephritic syndrome in 27 (39.1%) and renal dysfunction with proteinuria in 31 (44.9%).RESULTS: The most common causes of secondary amyloidosis were Familial Mediterranean Fever in 17 of the 62 patients, chronic inflammatory diseases in 17 patients and chronic infection in 13 patients. No cause was determined in 12 patients. Multiple myeloma was present in 5 patients with primary amyloidosis. At the time of diagnosis with amyloidosis, 19 patients were stage 1, 15 stage 2, 5 stage 3A, 12 stage 3B, 10 stage 4 and 8 stage 5. The baseline hemoglobin, serum albumin, creatinine, sodium, potassium, calcium, phosphorus, AST, ALT, PTH, SAA, CRP levels, average daily urinary protein excretion and baseline GFR values were not significantly different in primary and secondary amyloidosis patients. The treatment was medical in 62.3% of the patients, dialysis in 31.9% and renal transplantation in 5.8%.CONCLUSION: The reliability of renal biopsy in the diagnosis of amyloidosis is high. However, genetic studies for the diagnosis of idiopathic cases and special histological staining methods should be considered
Investigation of The Effects of Tarantula Cubensis Alcoholic Extract and Anabolic Androgenic Steroid Use on Osteological Development in Some Long Bones in Rats in The Growing Period.
No full textDoğal anabolik androjenik steroid (AAS) olan testosteron özellikle puberte döneminde
yüksek anabolik etkisi nedeniyle kas kütlesinde ve gücünde artıĢa neden olmaktadır. Bu nedenle
testosteronun sentetik analogları sporcular arasında sıkça kullanılmaktadır. Ancak bu testosteron
türevlerinin bazı sporcular tarafından suistimal edilerek kontrolsüz ve uzun süre kullanımı özellikle
iskelet sistemi baĢta olmak üzere birçok doku ve organda geri dönüĢümsüz hasarlara yol
açabilmektedir. Bu çalıĢmada anabolik androjenik steroid kullanımına bağlı olarak kemik doku
geliĢimi üzerinde oluĢabilecek olumsuz etkilerin, proliferatif ve rejeneratif etkilere sahip olduğu
belirtilen Tarantula cubensis alkolik ekstraktı (TCAE) kullanılarak giderilip giderilemeyeceği, bazı
uzun kemiklerin incelenmesi sonucunda elde edilen verilerle ortaya konulmaya çalıĢılmıĢtır.
ÇalıĢma, beĢ haftalık 36 adet Wistar Albino ırkı rat üzerinde, TCAE ile birlikte testosteron
türevi olarak metenolon enantat (ME) kullanılarak yapıldı. ÇalıĢma süresince hayvanlar her kafeste en
fazla beĢ adet olacak Ģekilde sekiz adet polisulfon yapıdaki kafeslerde, 24±1oC, %60 atmosferik nemli
ve ıĢığın 12 saat aydınlık/12 saat karanlık sağlandığı ortamda barındırıldı. Standart rat yemi ve su
ihtiyaçları adlibitum olarak sağlandı. Kontrol grubunda altı, diğer gruplarda 10 adet olarak
gruplandırıldı. Haftada bir kez 7 hafta boyunca, Kontrol grubuna serum fizyolojik (SF) 0.2 ml/rat
dozunda deri altı (SC), TCAE grubuna Tarantula cubensis alkolik ekstraktı 0.2 ml/rat dozunda SC,
ME grubuna metenolon enantat 10 mg/kg dozunda ĠM, TCAE + ME grubuna ise TCAE 0.2 ml/rat
dozunda SC ve metenolon enantat 10 mg/kg dozunda ĠM olarak uygulandı. Son uygulamadan bir
hafta sonra sakrifiye edilen hayvanlardan femur ve humerus kemikleri alınarak belirlenen anatomik
referans noktalarından (uzunluk, corpus kalınlığı, cavum medullare çapı, cortex kalınlığı) yapılan
ölçüm sonuçlarının değerlendirilmesinde gruplar arasında istatistiki farklar gözlenmedi (P>0.05).
Sonuç olarak geliĢme dönemindeki ratlara normal dozlarda metenolon enantat ve TCAE
uygulamasının femur ve humerus kemikleri geliĢim üzerine etkisinin olmadığı, ancak yüksek dozlarda
farklı etkiler gözlenebileceği ifade edilebilir.Testosterone, which is a natural anabolic androgenic steroid (AAS), causes an increase in
muscle mass and strength due to its high anabolic effect, especially during puberty. For this reason,
synthetic analogues of testosterone are frequently used among athletes. However, the abuse of these
testosterone derivatives by some athletes and their uncontrolled and long-term use can cause
irreversible damage to many tissues and organs, especially the skeletal system. In this study, it was
tried to reveal whether the negative effects that may occur on bone tissue development due to the use
of anabolic androgenic steroids can be eliminated by using Tarantula cubensis alcoholic extract
(TCAE), which is stated to have proliferative and regenerative effects, with the data obtained as a
result of the examination of some long bones.
The study was performed on 36 five-week-old Wistar Albino rats using TCAE together with
methenolone enanthate (ME) as a testosterone derivative. During the study, the animals were housed
in eight polysulfone cages, a maximum of five in each cage, at 24±1oC, 60% atmospheric humidity
and 12 hours of light / 12 hours of darkness. Requirements of standard rat feed and water were
provided adlibitum. They were divided as 6 in the control group and 10 in the other groups. Once a
week for 7 weeks, saline (SF) 0.2 ml/rat subcutaneously (SC) in to control group, Tarantula cubensis
alcoholic extract 0.2 ml/rat SC in to TCAE group, methenolone enanthate 10 mg/kg IM in to ME
group, Tarantula cubensis alcoholic extract 0.2 ml/rat SC and methenolone enanthate 10 mg/kg IM
was administered in to TCAE + ME group. No statistical differences were observed between the
groups in the evaluation of the measurement results made from the anatomical reference points
(length, corpus thickness, cavum medullare diameter, cortex thickness) determined by taking the
femur and humerus bones from animals sacrificed one week after the last application (P>0.05). As a
result, it can be stated that the administration of methenolone enanthate and TCAE at normal doses to
rats in the growing period has no effect on the development of the femur and humerus bones, but
different effects can be observed at high doses
The efects of alone and combined treatment of Tarantula cubensis alcoholic extract and Methenolone Enanthate on two long bones of young Rats
Full text linkThe aim of this study was to determine the effects of alone and combined treatment of Tarantula cubensis alcoholic extract (TCAE) and Methenolone Enanthate (ME) on morphometric parameters of humerus and femur in young rats. In this study, 36 five–week–old Wistar Albino rats were used. The animals were divided into 4 groups; Control group (n:6, normal saline solution, 0.2 mL·rat-1, subcutaneously –SC–), TCAE group (Tarantula cubensis alcoholic extract, 0.2 mL·rat-1, SC), ME group (Methenolone Enanthate), 10 mg·kg-1, intramuscularly –IM–) and TCAE + ME group (Tarantula cubensis alcoholic extract, 0.2 mL·rat-1, SC + Methenolone Enanthate, 10 mg·kg-1, IM). Drug treatments were done once a week for 7 weeks. At the end of the experiment, all the animals were euthanized and their humerus and femur bones were resected and their morphometric parameters were determined. No statistical differences were determined (P>0.05) between the groups in terms of the anatomical reference points (length, corpus thickness, cavum medullare diameter, and cortex thickness) of humerus and femur bones. In conclusion, it was found that alone and combined treatments of Tarantula cubensis alcoholic extract and ME (at normal dose) had no effects on morphometric parameters of humerus and femur bones in rats in the growing period. However, these effects may not be observed at high–dose and long–term treatments in rats
Nursen Karas life, and works of art
No full text1938 yılında Balıkesir ilinin Burhaniye ilçesinde doğan Hacer Nursen Karas, yazılarını 1952 yılından itibaren dönemin birçok dergisinde yayımlama fırsatı bulmuştur. Yazarın dört adet hikâye, üç adet şiir başta olmak üzere birer adet çocuk hikâyeleri, tiyatro, gezi yazısı, tiyatro eleştirisi, mektup ve düşünce yazısı türlerinden toplam on üç adet yayımlanmış kitabı bulunmaktadır. Hikâye ve tiyatroları başta olmak üzere birçok eserinde hayatından kesitler sunan Nursen Karas, eserlerinin çeşitliliğinden de görüldüğü üzere çok yönlü bir sanatçıdır. Birçok alanda eser vermiş olmasına rağmen edebiyat dünyasında, hikâyeci olarak tanınmaktadır. Eserlerinde genellikle bireysel konular üzerinde duran Nursen Karas, hikâye ve tiyatrolarında toplumsal konulara da zaman zaman yer vermiştir. Kadın-erkek eşitsizliği, bilinçsiz kentleşme, hayvan ve doğa katliamı, onun eserlerinde kendine yer bulan toplumsal konulardır. Yüksek Lisans tezi olarak hazırlanan bu çalışma ile edebiyat tarihimizde Nursen Karas'ın yerini belirterek bu alandaki açığı kapatmayı umuyoruz.Born in 1938 in Burhaniye, Hacer Nursen Karas, publishing writings have found opportunity in many magazines of the period since 1952. Author of four stories, a total of three theaters, especially poetry, opinion articles, letters, has a total of twelve published books including travel writing and theater criticism. Story and offers a glimpse into life in the theater of many works, especially if Nursen Karas, is a versatile artist, as seen in the works. Although not work in many areas is known as a storyteller in the world of literature. If is usually fixed on individual topics in the works Nursen Karas social issues in the work place it has also from time to time. Gender inequality, urbanization unconscious, animals and nature are social issues massacre its place in his works. Master's thesis prepared as Nursen Karas our literary history with this study we hope to close the gap in this area by specifying the location
Telescopic Aortic Arch: A New Entity in Marfan Syndrome
Full text linkTelescopic aortic arch is a consequence of aortic dissection in Marfan's syndrome, which has not been reported previously. This paper presents the first case of telescopic aortic arch secondary to chronic aortic dissection, as an incidental finding of a forensic autopsy. Here we present a sudden death of a 20 years old male due to cardiac tamponade sourcing from the rupture of ascending aorta. At autopsy, there was a haemopericardium of 800 cc, which comprised blood and clot. The ascending thoracic aorta was dilated and a 1.2 cm ragged linear complete rupture was noticed on the medial side of the front wall of ascending aorta. Examination of aorta showed a second/inner aortic arch just as a tube lying inside the aortic arch. The inner aortic arch was arrised 2.5 cm above aortic valves and lasted at the beginning of the descending aorta. It was 10 cm in length with a lumen 2 cm in diameter and was associated with truncus brachiosephalicus, left common carotid, and left subclavian arteries
The Effect of Sex and Species on Bill Variation in Chukar Partridge (Alectoris Chukar) and Grey Partridge (Perdix Perdix): Insight from Three-Dimensional Geometric Morphometric Analysis and Linear Morphometric Analysis
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