834 research outputs found
Medical aesthetics – Current trends and a review of its applications
No full textMedical aesthetics is the use of a procedure or product for a therapeutic indication which is conventionally used for aesthetics. Several medical conditions are now being treated with products, procedures or equipment that are conventionally used for aesthetic indications. This has widened the scope of treatment modalities available for dermatologists to treat various indications that fall outside the purview of aesthetic dermatology. The authors present aesthetic treatment modalities and procedures which can be used for medical aesthetics, their present-day status and usefulness in field of therapeutics with a review of published literature from “Medline” (via “PubMed”), “Cochrane,” the Virtual Health Library, and Google Scholar
Aerospace dermatology
No full textEvolutionarily, man is a terrestrial mammal, adapted to land. Aviation and now space/microgravity environment, hence, pose new challenges to our physiology. Exposure to these changes affects the human body in acute and chronic settings. Since skin reflects our mental and physical well-being, any change/side effects of this environment shall be detected on the skin. Aerospace industry offers a unique environment with a blend of all possible occupational disorders, encompassing all systems of the body, particularly the skin. Aerospace dermatologists in the near future shall be called upon for their expertise as we continue to push human physiological boundaries with faster and more powerful military aircraft and look to colonize space stations and other planets. Microgravity living shall push dermatology into its next big leap-space, the final frontier. This article discusses the physiological effects of this environment on skin, effect of common dermatoses in aerospace environment, effect of microgravity on skin, and occupational hazards of this industry
Proceedings of ASME Turbo Expo 2013: Power for Land, Sea and Air, Volume 1A: Combustion, Fuels and Emissions
No full textShahrokh Etemad (with Sandeep Alavandi and Benjamin Baird) is a contributing author, Fuel Flexible Rich Catalytic Lean Burn System for Low Btu Fuels
Three Dimensional High Contrast Gratings based Hollow Core Waveguide for Chip Scale Integrated Optical Interconnects
No full textME, ECEDThree dimensional high contrast gratings based hollow core waveguide is a potential
candidate for telecommunication systems which provides a promising platform to realize
integrated optical interconnects. These have been comprehensively studied over the years
due to its diverse applications in the communication systems. With advancement of
technologythese days as we are doing scaling the size of devices and distance between the
devices is reducing which makes interconnects more important in communication system. To
maintain such high speed and small size optical interconnects are required which can play
crucial role to achieve today’s high speed large bandwidth requirementsThe high reflectivity,
high speed and high bandwidth of HCGs based Hollow waveguide is one of the key
component for integrated chip scale optical interconnects.This can be used to guide light and
transmit Tb/s data over the communication link and attracted a lot of attention for next
generation communication network as well as high performance computing applications.SOI
is an ideal platform for the development of passive optical interconnects like Hollow
waveguide. Several key challenges exist in developing the waveguide, including fabrication
difficulties, dispersion and non linearity. Usinghigh contrast gratings, the fabrication
difficulties can be minimized. Dispersion remains to be the most dominant source in the
system of data loss. From the aspects of reflectivity, bandwidth, dispersion and non linearity,
using high contrast gratings in waveguide approach is widely popular. Modified approach
involves the high contrast gratings with high index material surrounded by a low-index
material. The refractive index difference is maintained high that is greater than 2.4 which
provides high reflectivity. Parameters on which reflectivity of waveguide mainly depends are
grating thickness (tg), grating period (Λ), and duty cycle (η). Important design attribute is the
sub wavelength size of gratings
Acute Ethanol Administration Rapidly Increases Phosphorylation of Conventional Protein Kinase C in Specific Mammalian Brain Regions in Vivo
No full textBackground
Protein kinase C (PKC) is a family of isoenzymes that regulate a variety of functions in the central nervous system including neurotransmitter release, ion channel activity, and cell differentiation. Growing evidence suggests that specific isoforms of PKC influence a variety of behavioral, biochemical, and physiological effects of ethanol in mammals. The purpose of this study was to determine whether acute ethanol exposure alters phosphorylation of conventional PKC isoforms at a threonine 674 (p-cPKC) site in the hydrophobic domain of the kinase, which is required for its catalytic activity.
Methods
Male rats were administered a dose range of ethanol (0, 0.5, 1, or 2 g/kg, intragastric) and brain tissue was removed 10 minutes later for evaluation of changes in p-cPKC expression using immunohistochemistry and Western blot methods.
Results
Immunohistochemical data show that the highest dose of ethanol (2 g/kg) rapidly increases p-cPKC immunoreactivity specifically in the nucleus accumbens (core and shell), lateral septum, and hippocampus (CA3 and dentate gyrus). Western blot analysis further showed that ethanol (2 g/kg) increased p-cPKC expression in the P2 membrane fraction of tissue from the nucleus accumbens and hippocampus. Although p-cPKC was expressed in numerous other brain regions, including the caudate nucleus, amygdala, and cortex, no changes were observed in response to acute ethanol. Total PKC? immunoreactivity was surveyed throughout the brain and showed no change following acute ethanol injection
No pain, no gain: an examination of the effects of self-threat on creativity
No full textThis paper investigates how different forms of self-threat influences different types of creativity. It examines which forms of self-threat hinder or boost creative capacity. The author illustrates the proposition that the threat from fixed self-domain enhances convergent creativity and that threats from dynamic self-domain enhance divergent creativity. This research adds to current knowledge of creativity literature by highlighting self-threats and it differentiates effects on both divergent creativity and convergent creativity.February 201
Formulation and evaluation of controlled release matrix mucoadhesive tablets of domperidone using Salvia plebeian gum
No full textThe aim of study was to prepare controlled release matrix mucoadhesive tablets of domperidone using Salvia plebeian gum as natural polymer. Tablets were formulated by direct compression technology employing the natural polymer in different concentrations (5, 10, 15 and 20% w/w). The prepared batches were evaluated for drug assay, diameter, thickness, hardness and tensile strength, swelling index, mucoadhesive strength (using texture analyzer) and subjected to in vitro drug release studies. Real-time stability studies were also conducted on prepared batches. In vitro drug release data were fitted in various release kinetic models for studying the mechanism of drug release. Tensile strength was found to increase from 0.808 ± 0.098 to 1.527 ± 0.10 mN/cm 2 and mucoadhesive strength increased from 13.673 ± 1.542 to 40.378 ± 2.345 N, with an increase in the polymer concentration from 5 to 20% (A1 to A4). Swelling index was reported to increase with both increase in the concentration of gum and the time duration. The in vitro drug release decreased from 97.76 to 83.4% (A1 to A4) with the increase in polymer concentration. The drug release from the matrix tablets was found to follow zero-order and Higuchi models, indicating the matrix-forming potential of natural polymer. The value of n was found to be between 0.5221 and 0.8992, indicating the involvement of more than one drug release mechanism from the formulation and possibly the combination of both diffusion and erosion. These research findings clearly indicate the potential of S. plebeian gum to be used as binder, release retardant and mucoadhesive natural material in tablet formulations
Shortness of breath in a patient with complete heart block and permanent pacemaker: A case of effective pacemaker reprogramming
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